CCR10
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Official Full Name
chemokine (C-C motif) receptor 10
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Overview
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008] -
Synonyms
CCR10; chemokine (C-C motif) receptor 10; GPR2; C-C chemokine receptor type 10; CCR-10; CC-CKR-10; C-C CKR-10; CC chemokine receptor 10; G protein-coupled receptor 2; G-protein coupled receptor 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
CCR10 involved in several pathways and played different roles in them. We selected most pathways CCR10 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | LEPA;CCR7;KDRL;IL22RA1;CRFB4;IFNAR1;TNFRSF19;CCL3;PDGFAB |
| Chemokine signaling pathway | PLCB3;RLN1;CXCR4;CCR1L1;ADRBK1;PREX1;GNG8;CCR9;CCL11 |
| Intestinal i | HLA-DQB1;BMA2;TGFB1;AICDA;CD80;MADCAM1;HLA-DRB5;BLB1;HLA-DPA1 |
| ne network for IgA production | HLA-DRA;IL15;CXCR4A;CXCL12A;BMA1;CCL27B;HLA-DRB4;CD40;MHC2DAB |
CCR10 has several biochemical functions, for example, C-C chemokine receptor activity, G-protein coupled receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR10 itself. We selected most functions CCR10 had, and list some proteins which have the same functions with CCR10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| C-C chemokine receptor activity | CCR10;CCR9;CCR1;CCR5;GPR75;CCR1L1;CCBP2;CCR6A;CCR7 |
| G-protein coupled receptor activity | GPR52;VALOPA;GPR75;EDNRAA;GPR1;GPR146;GPR88;S1PR5A;GPR78 |
CCR10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR10 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR10.
FYN; NCK1; GRB2; PRRC2A
Gene Family
Research Area
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