CCR3

  • Official Full Name

    chemokine (C-C motif) receptor 3

  • Overview

    The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described.
  • Synonyms

    CCR3; chemokine (C-C motif) receptor 3; CKR3; CD193; CMKBR3; CC-CKR-3; MGC102841; C-C chemokine receptor type 3; CCR-3; C-C CKR-3; OTTHUMP00000209745; b-chemokine receptor; CC chemokine receptor 3; eosinophil eotaxin receptor; eosinophil CC chemokine receptor; Chemokine (C C motif) receptor 3; Chemokine (CC) receptor 1 like 2; Eosinophil CC chemokine receptor 3; Macrophage inflammatory protein 1 alpha receptor like 2; OTTHUMP00000164718; OTTHUMP00000209746; OTTHUMP00000209747; OTTHUMP00000209748; CD193 antigen;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCR3-0294H Active Recombinant Human CCR3 Full Length Transmembrane protein, Flag tagged(Nanodisc) HEK293 Flag
Human CCR3-10884H Recombinant Human CCR3, GST-tagged E.coli GST 310-354a.a.
Human CCR3-0690H Recombinant Human CCR3 Protein Wheat Germ N/A
Human CCR3-0691H Recombinant Human CCR3 Protein, GST-Tagged Wheat Germ GST
Human CCR3-7694HCL Recombinant Human CCR3 293 Cell Lysate HEK293 N/A
Human CCR3-3006HF Recombinant Full Length Human CCR3 Protein In Vitro Cell Free System 261 amino acids
Human CCR3-1073HFL Recombinant Human CCR3 protein, His&Flag-tagged HEK293 His&Flag 1-373 aa
Human CCR3-3007HF Recombinant Full Length Human CCR3 Protein, GST-tagged In Vitro Cell Free System GST 355 amino acids
Mouse CCR3-3015M Recombinant Mouse CCR3 Protein Mammalian Cell His
Mouse CCR3-1422M-B Recombinant Mouse CCR3 Protein Pre-coupled Magnetic Beads HEK293
Mouse CCR3-1422M Recombinant Mouse CCR3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CCR3-1228R Recombinant Rat CCR3 Protein Mammalian Cell His
Rat CCR3-886R-B Recombinant Rat CCR3 Protein Pre-coupled Magnetic Beads HEK293
Rat CCR3-886R Recombinant Rat CCR3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Canis lupus familiaris (Dog) (Canis familiaris) RFL16676CF Recombinant Full Length Dog C-C Chemokine Receptor Type 3(Ccr3) Protein, His-Tagged E.coli expression system His Full Length (1-359)
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) RFL25982CF Recombinant Full Length Chlorocebus Aethiops C-C Chemokine Receptor Type 3(Ccr3) Protein, His-Tagged E.coli expression system His Full Length (1-355)
Cynomolgus Monkey CCR3-378C Recombinant Cynomolgus CCR3 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CCR3-126C Recombinant Cynomolgus Monkey CCR3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CCR3-126C-B Recombinant Cynomolgus Monkey CCR3 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL3135HF Recombinant Full Length Human C-C Chemokine Receptor Type 3(Ccr3) Protein, His-Tagged E.coli expression system His Full Length (1-355)
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL9135MF Recombinant Full Length Macaca Fascicularis C-C Chemokine Receptor Type 3(Ccr3) Protein, His-Tagged E.coli expression system His Full Length (1-355)
Macaca mulatta (Rhesus macaque) RFL12249MF Recombinant Full Length Macaca Mulatta (Rhesus Macaque) C-C Chemokine Receptor Type 3(Ccr3) Protein, His-Tagged E.coli expression system His Full Length (1-355)
Mus musculus (Mouse) RFL15859MF Recombinant Full Length Mouse Probable C-C Chemokine Receptor Type 3(Ccr3) Protein, His-Tagged E.coli expression system His Full Length (1-359)
Rattus norvegicus (Rat) RFL2383RF Recombinant Full Length Rat C-C Chemokine Receptor Type 3(Ccr3) Protein, His-Tagged E.coli expression system His Full Length (1-359)
Rhesus Macaque CCR3-706R Recombinant Rhesus monkey CCR3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CCR3-533R Recombinant Rhesus Macaque CCR3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CCR3-533R-B Recombinant Rhesus Macaque CCR3 Protein Pre-coupled Magnetic Beads HEK293
Kit-0985 Fluorimetric Hydrogen Peroxide Assay Kit (Near Infrared Fluorescence) N/A
Kit-1639 CCR3 CHO-K1 β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CCR3 involved in several pathways and played different roles in them. We selected most pathways CCR3 participated on our site, such as Chemokine receptors bind chemokines, Chemokine signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chemokine receptors bind chemokinesCXCR6;CCR6;CCR7;CCRL2;CCR9;AMCF-II;CCR1;CCBP2;CCR5
Chemokine signaling pathwayBCAR1;FOXO3;CXCL12;NFKBIA;ARRB2;PTK2B;CXCL13;GNG7;PRKCB
Class A/1 (Rhodopsin-like receptors)INSL3;FPR-RS3;LPAR2B;PROKR1A;GPR4;ANXA1;ADRA1B;UTS2D;NTS
Cytokine-cytokine receptor interactionLOC100033925;IL22RA2;IL10RA;IL20RB;GHRA;Flt3l;LIF;CSF1RA;CCR9
G alpha (i) signalling eventsCCR1;TAS2R16;OPN1SW;TAS2R7;FPR-RS3;GAL;RLN3A;RGS6;ADRA2C
GPCR downstream signalingANXA1B;CRHR2;GPR4;KALRNB;CALCB;RGS6;RXFP2;ECT2;OR2AP1
GPCR ligand bindingSST;CCR9;OXGR1;CRHR2;CD97;GPR39;PNOC;CCR3;SSTR3
GPCRs, Class A Rhodopsin-likeOPN1MW;DRD4;HRH3;CMKLR1;GPR18;GPR17;CCR3;CCR1;OPN1SW

CCR3 has several biochemical functions, for example, C-C chemokine receptor activity, chemokine receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR3 itself. We selected most functions CCR3 had, and list some proteins which have the same functions with CCR3. You can find most of the proteins on our site.

Function Related Protein
C-C chemokine receptor activityCCR6A;CCR1L1;CCR7;CCR8;CCR6;CCBP2;CCR5;GPR75;CCR10
chemokine receptor activityCXCR7B;CCR6;CCR3;CCR5;GPR17;RGRB;RGRA;CX3CR1;ACKR3B
protein bindingNIF3L1;NOC4L;CDKL3;LDHA;DRAP1;Fert2;FAM184A;BLOC1S2A;ZNF398

CCR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR3.

CCL11

Gene Family

Chemokines Cytokines

Research Area

Related articles

Sugaya, M; et al. Chemokines and Skin Diseases. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 63:109-115(2015).
Makita, N; Hizukuri, Y; et al. IL-10 enhances the phenotype of M2 macrophages induced by IL-4 and confers the ability to increase eosinophil migration. INTERNATIONAL IMMUNOLOGY 27:131-141(2015).
  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
06/28/2020

    Implementing protein reagents reduces operational risks in experiments, thereby improving experimental safety.

    11/23/2019

      Manufacturers of protein reagents are committed to product innovation and improvement, continuously elevating quality standards.

      09/22/2019

        Protein reagents exhibit stable quality, providing consistent experimental results and reliable data.

        Q&As (0)

        Ask a question

        Ask a Question for All CCR3 Products

        Required fields are marked with *

        My Review for All CCR3 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends