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Official Full Name chemokine (C-C motif) receptor 3
Background The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described.
Synonyms CCR3; chemokine (C-C motif) receptor 3; CKR3; CD193; CMKBR3; CC-CKR-3; MGC102841; C-C chemokine receptor type 3; CCR-3; C-C CKR-3; OTTHUMP00000209745; b-chemokine receptor; CC chemokine receptor 3; eosinophil eotaxin receptor; eosinophil CC chemokine receptor; Chemokine (C C motif) receptor 3; Chemokine (CC) receptor 1 like 2; Eosinophil CC chemokine receptor 3; Macrophage inflammatory protein 1 alpha receptor like 2; OTTHUMP00000164718; OTTHUMP00000209746; OTTHUMP00000209747; OTTHUMP00000209748; CD193 antigen
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CCR3-0690H Recombinant Human CCR3 Protein Wheat Germ N/A
    Human CCR3-0691H Recombinant Human CCR3 Protein, GST-Tagged Wheat Germ GST
    Human CCR3-10884H Recombinant Human CCR3, GST-tagged E.coli GST
    Human CCR3-7694HCL Recombinant Human CCR3 293 Cell Lysate HEK293 N/A
    Mouse CCR3-3015M Recombinant Mouse CCR3 Protein Mammalian Cell His
    Rat CCR3-1228R Recombinant Rat CCR3 Protein Mammalian Cell His
    Cynomolgus Monkey CCR3-378C Recombinant Cynomolgus CCR3 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque CCR3-706R Recombinant Rhesus monkey CCR3 Protein, His-tagged Mammalian Cell His
    Kit-0985 Fluorimetric Hydrogen Peroxide Assay Kit (Near Infrared Fluorescence) N/A
    Kit-1639 CCR3 CHO-K1 β-Arrestin GPCR Assay Kit N/A

    ccr3 involved in several pathways and played different roles in them. We selected most pathways ccr3 participated on our site, such as Chemokine receptors bind chemokines, Chemokine signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with ccr3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chemokine receptors bind chemokines CCR8; CCR1; CCRL2; CCBP2; CCR6; AMCF-II; ACKR4; CCL19A.2; CCR3; CCR5
    Chemokine signaling pathway GSK3A; CCL22; ROCK1; GM13306; RAC1; GNB3; PIK3R5; RASGRP2; ARRB2; SHC4
    Class A/1 (Rhodopsin-like receptors) OXER1; RLN2; DRD4; GPR39; CGA; OPN5; GPR37L1; CX3CR1; POMCB; CHRM3
    Cytokine-cytokine receptor interaction TNFRSF10A; BMPR1BB; CXCR6; PDGFRB; PDGFC; CCR1; IL23; Kitl; CNTFR; Cxcl15
    G alpha (i) signalling events HEBP1; RGS12; ANXA1B; OPN1MW; OXER1; PYYA; PENK; GPR18; CXCR7B; SSTR2
    GPCR downstream signaling GNA13; ABHD6B; CHRM4; ARHGEF9; CXCR6; OXGR1A.1; LPAR1; KALRN; CALCB; TRPC3
    GPCR ligand binding RAMP2; KEL; OPN1MW2; CRHB; EMR1; RLN3; ADRA2B; ADORA2A; LPAR2B; NPB
    GPCRs, Class A Rhodopsin-like OR3A4P; GPR37L1; NPFFR2; FPR-RS4; CCR3; SSTR3; CNR2; DRD4; GPR68; AGTR2

    ccr3 has several biochemical functions, for example, C-C chemokine receptor activity, chemokine receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ccr3 itself. We selected most functions ccr3 had, and list some proteins which have the same functions with ccr3. You can find most of the proteins on our site.

    Function Related Protein
    C-C chemokine receptor activity CCR8; CCR5; CCR6; CCR3; CCR7; CCR9; CCR1L1; CCR10; CCBP2; GPR75
    chemokine receptor activity CXCR3; CX3CR1; CCR12A; ACKR4; CCR9A; CCR6; CCBP2; CCR5; CXCR3.1; CXCR1
    protein binding TXNIP; KCNE2; MSH2; UFC1; TBC1D20; TEX13A; DNAJB2; SPRYD7; TGFA; CBX8

    ccr3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ccr3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ccr3.


    Sugaya, M; et al. Chemokines and Skin Diseases. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 63:109-115(2015).
    Makita, N; Hizukuri, Y; et al. IL-10 enhances the phenotype of M2 macrophages induced by IL-4 and confers the ability to increase eosinophil migration. INTERNATIONAL IMMUNOLOGY 27:131-141(2015).

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