|Official Full Name||chemokine (C-C motif) receptor 3|
|Background||The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described.|
|Synonyms||CCR3; chemokine (C-C motif) receptor 3; CKR3; CD193; CMKBR3; CC-CKR-3; MGC102841; C-C chemokine receptor type 3; CCR-3; C-C CKR-3; OTTHUMP00000209745; b-chemokine receptor; CC chemokine receptor 3; eosinophil eotaxin receptor; eosinophil CC chemokine receptor; Chemokine (C C motif) receptor 3; Chemokine (CC) receptor 1 like 2; Eosinophil CC chemokine receptor 3; Macrophage inflammatory protein 1 alpha receptor like 2; OTTHUMP00000164718; OTTHUMP00000209746; OTTHUMP00000209747; OTTHUMP00000209748; CD193 antigen|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ccr3 involved in several pathways and played different roles in them. We selected most pathways ccr3 participated on our site, such as Chemokine receptors bind chemokines, Chemokine signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with ccr3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Chemokine receptors bind chemokines||CCR8; CCR1; CCRL2; CCBP2; CCR6; AMCF-II; ACKR4; CCL19A.2; CCR3; CCR5|
|Chemokine signaling pathway||GSK3A; CCL22; ROCK1; GM13306; RAC1; GNB3; PIK3R5; RASGRP2; ARRB2; SHC4|
|Class A/1 (Rhodopsin-like receptors)||OXER1; RLN2; DRD4; GPR39; CGA; OPN5; GPR37L1; CX3CR1; POMCB; CHRM3|
|Cytokine-cytokine receptor interaction||TNFRSF10A; BMPR1BB; CXCR6; PDGFRB; PDGFC; CCR1; IL23; Kitl; CNTFR; Cxcl15|
|G alpha (i) signalling events||HEBP1; RGS12; ANXA1B; OPN1MW; OXER1; PYYA; PENK; GPR18; CXCR7B; SSTR2|
|GPCR downstream signaling||GNA13; ABHD6B; CHRM4; ARHGEF9; CXCR6; OXGR1A.1; LPAR1; KALRN; CALCB; TRPC3|
|GPCR ligand binding||RAMP2; KEL; OPN1MW2; CRHB; EMR1; RLN3; ADRA2B; ADORA2A; LPAR2B; NPB|
|GPCRs, Class A Rhodopsin-like||OR3A4P; GPR37L1; NPFFR2; FPR-RS4; CCR3; SSTR3; CNR2; DRD4; GPR68; AGTR2|
ccr3 has several biochemical functions, for example, C-C chemokine receptor activity, chemokine receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ccr3 itself. We selected most functions ccr3 had, and list some proteins which have the same functions with ccr3. You can find most of the proteins on our site.
|C-C chemokine receptor activity||CCR8; CCR5; CCR6; CCR3; CCR7; CCR9; CCR1L1; CCR10; CCBP2; GPR75|
|chemokine receptor activity||CXCR3; CX3CR1; CCR12A; ACKR4; CCR9A; CCR6; CCBP2; CCR5; CXCR3.1; CXCR1|
|protein binding||TXNIP; KCNE2; MSH2; UFC1; TBC1D20; TEX13A; DNAJB2; SPRYD7; TGFA; CBX8|
ccr3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ccr3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ccr3.