CCR8

  • Official Full Name

    chemokine (C-C motif) receptor 8

  • Overview

    CCR8 (C-C chemokine receptor 8, CKR-L1, cy6) is a member of the beta-chemokine receptor family that is preferentially expressed in the thymus. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites
  • Synonyms

    CCR8; chemokine (C-C motif) receptor 8; CMKBR8, CMKBRL2; C-C chemokine receptor type 8; CDw198; CKR L1; CY6; GPR CY6; TER1; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Cynomolgus
  • Cynomolgus monkey
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Mus musculus (Mouse)
  • Rhesus macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Wheat Germ
  • GST
  • hFc tag
  • His
  • His (Fc)
  • Avi
  • Flag
  • SUMO
  • mFc tag
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCR8-492H Active Recombinant Human CCR8 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human CCR8-485H Active Recombinant Human CCR8 Full Length Transmembrane protein, His-tagged(VLPs) HEK293 His 1-355aa
Human CCR8-954H Active Recombinant Human CCR8 Full Length Transmembrane protein(MNP) HEK293 N/A
Human CCR8-0697H Recombinant Human CCR8 Protein Wheat Germ N/A
Human CCR8-0698H Recombinant Human CCR8 Protein, GST-Tagged Wheat Germ GST
Human CCR8-481H Recombinant Human CCR8 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-355aa
Human CCR8-647H Recombinant Human CCR8 Protein, His-tagged E.coli N-His Met1-Ile69
Human CCR8-1479H Recombinant Human CCR8 Transmembrane protein, His-tagged In vitro E. coli expression system His 74-129aa
Human CCR8-1078HFL Recombinant Human CCR8 protein, His&Flag-tagged HEK293 His&Flag 1-355 aa
Human CCR8-01H Recombinant Human CCR8 Protein, mFc-Tagged HEK293 mFc tag
Human CCR8-1480H Recombinant Human CCR8 Transmembrane protein, His-tagged(Nanodisc) In vitro E. coli expression system His 74-129aa
Human CCR8-3031HF Recombinant Full Length Human CCR8 Protein, GST-tagged In Vitro Cell Free System GST 355 amino acids
Human CCR8-3022HF Recombinant Full Length Human CCR8 Protein In Vitro Cell Free System 392 amino acids
Human CCR8-0184H Active Recombinant Human CCR8 protein HEK293 N/A Asp 2 - Leu 355
Human CCR8-911H Active Recombinant Human CCR8 Full Length Transmembrane protein(VLPs) HEK293 N/A Asp 2 - Leu 355
Mouse CCR8-3018M Recombinant Mouse Ccr8 Protein E.coli
Mouse CCR8-01M Recombinant Mouse CCR8 Protein, hFc-Tagged HEK293 hFc tag
Mouse Ccr8-2357M Recombinant Mouse Ccr8 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-353aa
Cynomolgus CCR8-01C Recombinant Cynomolgus CCR8 Protein, hFc-Tagged HEK293 hFc tag
Cynomolgus Monkey CCR8-380C Recombinant Cynomolgus CCR8 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CCR8-128C-B Recombinant Cynomolgus Monkey CCR8 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey CCR8-128C Recombinant Cynomolgus Monkey CCR8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus monkey CCR8-192C Recombinant Cynomolgus monkey CCR8 Full Length Transmembrane protein, His-SUMO-tagged In vitro E. coli expression system His-SUMO 1-355aa
Homo sapiens (Human) RFL3426HF Recombinant Full Length Human C-C Chemokine Receptor Type 8(Ccr8)-Vlps (Active) Protein, His-Tagged E.coli expression system His Full Length (1-355aa)
Homo sapiens (Human) RFL17422HF Recombinant Full Length Human C-C Chemokine Receptor Type 8(Ccr8) Protein, His-Tagged E.coli expression system His Full Length (1-355aa)
Macaca mulatta (Rhesus macaque) RFL14477MF Recombinant Full Length Macaca Mulatta C-C Chemokine Receptor Type 8(Ccr8) Protein, His-Tagged E.coli expression system His Full Length (1-356aa)
Mus musculus (Mouse) RFL21951MF Recombinant Full Length Mouse C-C Chemokine Receptor Type 8(Ccr8) Protein, His-Tagged E.coli expression system His Full Length (1-353)
Rhesus macaque CCR8-0294R Recombinant Rhesus macaque CCR8 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-356aa
Chicken CCR8-2675C Recombinant Chicken CCR8 Mammalian Cell His
Kit-0878 ADK Phosphorylation Assay Kit N/A
Kit-1162 CCR8 CHO-K1 β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CCR8 involved in several pathways and played different roles in them. We selected most pathways CCR8 participated on our site, such as Chemokine receptors bind chemokines, Chemokine signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chemokine receptors bind chemokinesCXCR6;CXCL13;CCR5;CX3CR1;CCL35.1;CCRL2;CCL27;CCL35.2;CCR8
Chemokine signaling pathwayCCR9;GM2506;CCL2;PIK3CB;CCL18;ADRBK1;IL-8;STAT3;PIK3CA
Class A/1 (Rhodopsin-like receptors)ADRA1B;PMCH;NMUR1;CXCR6;CXCL13;MLN;CXCR7B;NPFFR2;KEL
Cytokine-cytokine receptor interactionPF4V1;RELT;Ccl21c;CXCL12;CXCL16;IL26;ACKR3B;BMP7A;TNFRSF1A
G alpha (i) signalling eventsAPPA;HRH3;LPAR5A;OXGR1;RGS18;TAS2R16;S1PR3;ADORA1;S1PR1
GPCR downstream signalingSSTR1;CCK;RGS20;CCR7;CCR6;FGD4;VIP2;QRFP;ARHGEF18A
GPCR ligand bindingCYSLTR1;GPR4;GPR17;ADORA2A;RLN3;GPR39;GPR31B;OPN1LW;TAS2R3
GPCRs, Class A Rhodopsin-likeGPR32;NPFFR2;CCR8;SSTR2;FPR-RS4;GPR75;SSTR3;GPR63;CNR1

CCR8 has several biochemical functions, for example, C-C chemokine receptor activity, chemokine receptor activity, coreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR8 itself. We selected most functions CCR8 had, and list some proteins which have the same functions with CCR8. You can find most of the proteins on our site.

Function Related Protein
C-C chemokine receptor activityCCR7;CCBP2;GPR75;CCR3;CCR6;CCR6A;CCR9;CCR1;CCR5
chemokine receptor activityCCR9;CCR6;CXCR3.2;CCR1L1;CX3CR1;CXCR4B;RGRA;RGRB;CCR1
coreceptor activityPVRL1;RGMB;RAMP2;RAMP3;CXCR6;ACVR2A;CD8A;CD86;PVRL2

CCR8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR8.

Gene Family

Chemokines Cytokines

Research Area

Related articles

Santos-Costa, Q; Lopes, MM; et al. HIV-2 interaction with cell coreceptors: amino acids within the V1/V2 region of viral envelope are determinant for CCR8, CCR5 and CXCR4 usage. RETROVIROLOGY 11:-(2014).
Zhou, JH; Kang, N; et al. Anti-gamma delta TCR antibody-expanded gamma delta T cells: a better choice for the adoptive immunotherapy of lymphoid malignancies. CELLULAR & MOLECULAR IMMUNOLOGY 9:34-44(2012).
  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
09/26/2019

    The product's forward-thinking design was aligned with our lab's aspirations for cutting-edge research.

    09/21/2019

      The minimal variation across different batches enhanced the repeatability of our results.

      10/26/2016

        The product's ease of integration into our existing experimental setups minimized disruptions to our established processes.

        Q&As (7)

        Ask a question
        What is the primary function of C-C chemokine receptor type 8 (CCR8) in the immune system? 05/01/2021

        C-C chemokine receptor type 8 (CCR8) primarily functions in the immune system, playing a role in immune responses and cell migration.

        How does CCR8 influence the balance between immune tolerance and inflammation? 03/24/2021

        CCR8 plays a role in influencing the balance between immune tolerance and inflammation through its impact on T cell function.

        What diseases or conditions are associated with dysregulation or abnormal expression of CCR8? 11/19/2020

        Dysregulation or abnormal expression of CCR8 is associated with conditions like allergic diseases, autoimmune disorders, and certain cancers.

        In which immune cells is CCR8 predominantly expressed? 08/16/2020

        CCR8 is predominantly expressed in certain immune cells, including regulatory T cells (Tregs) and certain subsets of T lymphocytes.

        How does CCR8 contribute to the regulation of immune responses and cell migration? 04/01/2019

        CCR8 contributes to the regulation of immune responses and cell migration by responding to specific chemokines in the microenvironment.

        Are there specific chemokines that bind to CCR8, and what is their role in immune modulation? 11/23/2018

        Specific chemokines, such as CCL1, bind to CCR8, influencing immune modulation and cell trafficking.

        Are there therapeutic implications or potential targets related to CCR8 in immune-related disorders? 03/29/2016

        There are potential therapeutic implications related to CCR8 in immune-related disorders, making it a target of interest for drug development.

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