CCT3

  • Official Full Name

    chaperonin containing TCP1, subunit 3 (gamma)
  • Overview

    The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8.
  • Synonyms

    CCT3;chaperonin containing TCP1, subunit 3 (gamma);TRIC5;T-complex protein 1 subunit gamma;Cctg;CCT 3;CCT gamma;Chaperonin containing TCP1 subunit 3 (gamma);Chaperonin containing TCP1 subunit 3;hTRiC5;PIG48;T complex protein 1 gamma subunit;T complex protein 1 subunit gamma;TCP 1 gamma;TCP1 (t complex 1) ring complex polypeptide 5;T-complex protein 1, gamma subunit;TCP1 (t-complex-1) ring complex, polypeptide 5;CCT-gamma;TCP-1-gamma

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • Zebrafish
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • Yeast
  • Baculovirus
  • Mammalian cells
  • GST
  • His
  • Non
  • Avi
  • Fc
  • Flag
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
CCT3-10896H Recombinant Human CCT3, GST-tagged E.coli Human GST 245-544
CCT3-0711H Recombinant Human CCT3 Protein, GST-Tagged Wheat Germ Human GST
CCT3-1232R Recombinant Rat CCT3 Protein Mammalian Cells Rat His
CCT3-3024M Recombinant Mouse CCT3 Protein Mammalian Cells Mouse His
CCT3-9524Z Recombinant Zebrafish CCT3 Mammalian Cells Zebrafish His
CCT3-7690HCL Recombinant Human CCT3 293 Cell Lysate HEK293 Human Non
CCT3-1427M Recombinant Mouse CCT3 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
CCT3-1427M-B Recombinant Mouse CCT3 Protein Pre-coupled Magnetic Beads HEK293 Mouse
CCT3-2127HFL Recombinant Full Length Human CCT3 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
CCT3-3041HF Recombinant Full Length Human CCT3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 544 amino acids
CCT3-467H Recombinant Human CCT3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
Cct3-5288M Recombinant Mouse Cct3 protein Yeast Mouse Non
Cct3-5289M Recombinant Mouse Cct3 protein E.coli Mouse Non
CCT3-528H Recombinant Human CCT3 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
CCT3-528H-B Recombinant Human CCT3 Protein Pre-coupled Magnetic Beads HEK293 Human
Cct3-5290M Recombinant Mouse Cct3 protein, Avi-tagged, Biotinylated E.coli Mouse Avi
Cct3-5291M Recombinant Mouse Cct3 protein Baculovirus Mouse Non
Cct3-5292M Recombinant Mouse Cct3 protein Mammalian cells Mouse Non
Cct3-803M Recombinant Mouse Cct3 Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
CCT3-890R Recombinant Rat CCT3 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
CCT3-890R-B Recombinant Rat CCT3 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    CCT3 involved in several pathways and played different roles in them. We selected most pathways CCT3 participated on our site, such as Assembly of the primary cilium,Association of TriC/CCT with target proteins during biosynthesis,BBSome-mediated cargo-targeting to cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chaperonin-mediated protein folding TUBB4B,KIFC3,TCP1,PFDN6,FBXW9,PFDN4,PFDN1,TUBB4A,FBXW4,CCT4
    Association of TriC/CCT with target proteins during biosynthesis CCT2,CCT5,CCT8,TCP1,FBXW2,NOP56,FBXL5,FKBP9,FBXW9,KIFC3
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding TUBB4B,PFDN2,PFDN6,CCT8,PFDN4,TUBA1B,TUBA3D,PFDN1,CCT7,CCT4
    Assembly of the primary cilium IFT88,B9D2,TSGA14,TCTN3,HAUS2,HSPB11,IFT43,EXOC6,NEDD1,MKKS
    Cargo trafficking to the periciliary membrane CYS1,CNGA5,UNC119.1,BBS5,ARL13B,CCT8,EXOC5,SETD6,BBS10,CCT4
    Folding of actin by CCT/TriC CCT7,CCT2,TCP1,CCT4,CCT5,CCT8,CCT6A
    BBSome-mediated cargo-targeting to cilium BBS12,MKKS,BBS9,SSTR3,CCT8,TCP1,BBS7,TTC8,BBS2,SETD6
    Formation of tubulin folding intermediates by CCT/TriC CCT7,TUBA3D,CCT6A,CCT5,CCT2,TUBB4A,CCT8,CCT4,TUBA1B,TCP1

    Protein Function

    CCT3 has several biochemical functions, for example, ATP binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCT3 itself. We selected most functions CCT3 had, and list some proteins which have the same functions with CCT3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding NEK10,PAPSS2B,CKMA,FIGNL2,MAPK7,CAMK1D,EHD2,GMPS,PRKG1,HSPA1A
    unfolded protein binding CRYAB,DNAJB5,SIL1,HTRA2,RP2,HSP90AA1.2,APCS,PFDN6,PFDN5,PDRG1
    poly(A) RNA binding NHP2,RPS4X,ADARB2,MRM1,FAM98C,JUN,BUD13,HIST1H4A,MRPL3,SRSF9
    protein binding TBXA2R,CHERP,STK11,ELK4,HYLS1,RPS27A,BAI2,STOML2,LAMA4,POLG

    Interacting Protein

    CCT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCT3.

    PPP4C;PPP2CB;PPP2CA;STRN3;ILK;WRAP53

    Resources

    References

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