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Official Full Name chaperonin containing TCP1, subunit 3 (gamma)
Background The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8.
Synonyms CCT3; chaperonin containing TCP1, subunit 3 (gamma); TRIC5; T-complex protein 1 subunit gamma; Cctg; CCT 3; CCT gamma; Chaperonin containing TCP1 subunit 3 (gamma); Chaperonin containing TCP1 subunit 3; hTRiC5; PIG48; T complex protein 1 gamma subunit; T complex protein 1 subunit gamma; TCP 1 gamma; TCP1 (t complex 1) ring complex polypeptide 5; T-complex protein 1, gamma subunit; TCP1 (t-complex-1) ring complex, polypeptide 5; CCT-gamma; TCP-1-gamma
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CCT3-0711H Recombinant Human CCT3 Protein, GST-Tagged Wheat Germ GST
    Human CCT3-10896H Recombinant Human CCT3, GST-tagged E.coli GST
    Human CCT3-467H Recombinant Human CCT3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CCT3-7690HCL Recombinant Human CCT3 293 Cell Lysate HEK293 N/A
    Mouse CCT3-3024M Recombinant Mouse CCT3 Protein Mammalian Cell His
    Mouse Cct3-803M Recombinant Mouse Cct3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat CCT3-1232R Recombinant Rat CCT3 Protein Mammalian Cell His
    Zebrafish CCT3-9524Z Recombinant Zebrafish CCT3 Mammalian Cell His

    CCT3 involved in several pathways and played different roles in them. We selected most pathways CCT3 participated on our site, such as Assembly of the primary cilium, Association of TriC/CCT with target proteins during biosynthesis, BBSome-mediated cargo-targeting to cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Assembly of the primary cilium LZTFL1; HDAC6; CEP290; MKS1; TTC30A; CETN2; DCTN3; WDR19; CEP76; EXOC5
    Association of TriC/CCT with target proteins during biosynthesis CCT7; NOP56; FBXW4; CCT3; KIFC3; CCT8; CCT4; CCT2; CCT6A; FBXW2
    BBSome-mediated cargo-targeting to cilium TTC8; CCT5; MKKS; BBS2; BBS4; BBS5; TCP1; BBS1; CCT2; PROL1
    Cargo trafficking to the periciliary membrane CYS1; EXOC5; MKKS; CCT5; UNC119B; ARF4A; BBS12; TCP1; BBS10; PKD1
    Chaperonin-mediated protein folding CCT5; CCT3; FBXW9; KIFC3; PFDN6; NOP56; PFDN4; PFDN5; TUBA3D; CCT4
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding TUBB4A; PFDN5; CCT6A; PFDN1; CCT8; PFDN4; CCT2; CCT4; PFDN2; TUBA1B
    Folding of actin by CCT/TriC CCT3; CCT5; CCT7; CCT2; CCT6A; TCP1; CCT8; CCT4
    Formation of tubulin folding intermediates by CCT/TriC CCT8; TUBA3D; TUBA1B; TCP1; TUBB4B; CCT5; CCT2; CCT6A; TUBB4A; CCT3

    CCT3 has several biochemical functions, for example, ATP binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCT3 itself. We selected most functions CCT3 had, and list some proteins which have the same functions with CCT3. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA binding EIF4G2; RPS19; DQX1; DKC1; SNRPG; NLRP11; SCG3; AHNAK; PPP1R10; RPL17
    protein binding FAM127A; TBCD; ICA1; TBC1D14; CASP7; cgr2b; COIL; ZMAT2; THEMIS; APAF1
    unfolded protein binding HSPA8; RP2; H2-KE2; LRPAP1; PFDN2; DNAJA4; SRSF10; CCT6B; SYVN1; SSUH2.2

    CCT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCT3.


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