cd14

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cd14

Official Full Name CD14 molecule
Background The protein encoded by this gene is a component of the innate immune system. CD14 exists in two forms. Either it is anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 KDa) or is directly secreted from intracellular vesicles (56 KDa). CD14 takes its name from its inclusion in the cluster of differentiation group of cell surface marker proteins. CD14 was the first described pattern recognition receptor.
Synonyms CD14; monocyte differentiation antigen CD14; OTTHUMP00000159892; OTTHUMP00000223710; OTTHUMP00000223711; OTTHUMP00000224328; myeloid cell-specific leucine-rich glycoprotein
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Pig
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • GST
    • T7
    • human
    • IgG1
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Cd14-117M Recombinant Mouse Cd14 Protein, Fc-tagged NS0 Fc
    Human CD14-5896H Recombinant Human CD14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CD14-6224H Recombinant Human CD14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Cd14-810M Recombinant Mouse Cd14 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CD14-0721H Recombinant Human CD14 Protein, GST-Tagged Wheat Germ GST
    Human CD14-1604HCL Recombinant Human CD14 cell lysate Human Cell N/A
    Human CD14-204H Recombinant Human CD14, His-tagged E.coli His
    Human CD14-2100H Recombinant Human CD14 protein CHO N/A
    Human CD14-2109H Recombinant Human CD14 protein, His-tagged HEK293 His
    Human CD14-264H Recombinant Human CD14 protein CHO N/A
    Human CD14-28H Recombinant Human CD14, His-tagged HEK293 His
    Human CD14-3008H Recombinant Human CD14 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CD14-613H Recombinant Human CD14 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human CD14-789H Recombinant Human CD14 protein, His-tagged E.coli His
    Human CD14-90H Recombinant Human CD14 HEK293 N/A
    Human CDA069P Recombinant Human CD14 E.coli N/A
    Mouse Cd14-118M Recombinant Mouse Cd14, His-tagged CHO His
    Mouse Cd14-1385M Recombinant Mouse Cluster Of Differentiation 14, His-tagged CHO His
    Mouse Cd14-1711M Recombinant Mouse CD14 Antigen NS0 N/A
    Mouse Cd14-2270M Recombinant Mouse Cd14, His tagged Human Cell His
    Mouse CD14-2581MCL Recombinant Mouse CD14 cell lysate Human Cell N/A
    Mouse Cd14-3318M Recombinant Mouse Cd14, Fc-His tagged Human Cell Fc/His
    Mouse Cd14-58M Recombinant Mouse Cd14 protein, His-tagged Insect Cell His
    Rat CD14-1101R Recombinant Rat CD14 Protein, His-tagged HEK293 His
    Rat CD14-1235R Recombinant Rat CD14 Protein Mammalian Cell His
    Rat CD14-1469RCL Recombinant Rat CD14 cell lysate Human Cell N/A
    Rat Cd14-7484R Recombinant Rat Cd14, Fc tagged Human Cell Fc
    Rat Cd14-791R Recombinant Rat Cd14 protein, His & GST-tagged E.coli His/GST
    Cynomolgus Monkey CD14-1169CCL Recombinant Cynomolgus CD14 cell lysate Human Cell N/A
    Cynomolgus Monkey CD14-8847C Recombinant Cynomolgus CD14, His tagged Human Cell His
    Rhesus Macaque CD14-717R Recombinant Rhesus monkey CD14 Protein, His-tagged Mammalian Cell His
    Chicken CD14-3887C Recombinant Chicken CD14 Mammalian Cell His
    Pig CD14-790P Recombinant Pig CD14 protein, His & T7-tagged E.coli His/T7

    cd14 involved in several pathways and played different roles in them. We selected most pathways cd14 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with cd14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway NR4A1; CACNA1DA; C11orf52; PRKACB; MAP2K6; MAPKAPK2; LRRK2; GNG12A; MAP2K1; ACVR1C
    NF-kappa B signaling pathway MAP3K7IP3; IL1B; TICAM2; ERC1; TNFRSF11A; LTB; TNFSF13B; IL1R1; TAB2; LBP
    Phagosome RAC1B; ATP6V1G2; HLA-DMA; CALRL2; CLEC7A; RAB7; BMA1; RAB7B; CD209; ATP6V0CB
    Toll-like receptor signaling pathway MAP2K4A; TLR2; MAPK14B; AKT2L; CCL3L3; TAB2; CCL3; IFNA16; IFNA4; IRAK1
    Hematopoietic cell lineage CD9; GM2002; ITGA3; CD1D; CD1E, B2M; IL7; IL4; CD1A; GM13305; HLA-DRB4
    Regulation of actin cytoskeleton GSN; SSH3; PIP4K2C; ITGB1; ROCK2B; FGF1B; CFL2; ABI2A; ACTN3B; MSNA
    Pathogenic Escherichia coli infection KRT18; NCK2; TUBA1B; TUBB1; TUBB2B; TUBB7P; NCK1; CLDN1; WAS; ROCK1
    Salmonella infection ROCK2; PFN2; RHOGB; TLR5B; WASB; NOS2; NFKB1; TLR4BB; MYD88; RAB7A
    Pertussis GM5077; ITGA5; CALM2; MAPK11; C4BP; Hc; IRF1; NFKB1; CALML5; C1R
    Legionellosis CXCL2; NAIP6; ITGB2L; IL18; HSPA2; NAIP7; Casp3; CASP7; TNF; TLR5
    Amoebiasis TGFB2; SERPINB13; SERPINB3C; SERPINB2; ITGB2L; GNA15; GNAL; CXCL1; IL12B; LAMB2
    Tuberculosis IFNA14; MAPK9; SPHK2; BID; ATP6V0A4; HLA-DPB1; CARD9; Itgam&Itgb2; FCGR3; CALML5
    Transcriptional misregulation in cancer HDAC2; TLX3; SIX1; NFKBIZ; HIST1H3I; LMO2; HHEX; HIST1H3G; GZMB; PDGFA

    cd14 has several biochemical functions, for example, lipopolysaccharide binding, lipoteichoic acid binding, opsonin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cd14 itself. We selected most functions cd14 had, and list some proteins which have the same functions with cd14. You can find most of the proteins on our site.

    Function Related Protein
    lipopolysaccharide binding TLR2; SCARB1; SELP; BPIFC; KIAA0644; TREM2; PSMB4; TLR4; LBP; BPI
    lipoteichoic acid binding LBP; CD6; CD14; TLR2; TREM2
    opsonin receptor activity CD14
    peptidoglycan receptor activity CD14; PGLYRP3; PGLYRP2; PGLYRP1; PGLYRP4
    protein binding PCID2; Fzd4; CACNA2D1A; THOC5; PAX5; HMGB4; EXOC3L; CASC3; ETF1; PPP1R12C

    cd14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cd14 here. Most of them are supplied by our site. Hope this information will be useful for your research of cd14.

    FSTL1; IRAK3; DIP2A; TNFRSF1B; GJB2; POLR2J; PPP3R2; ARFGAP3; PHF20L1; b4dt77_human; TAF1; PPP1R12B; BUB1B; SVIL; OASL; TAF9; ARID2

    Dickson, MC; Ludbrook, VJ; et al. A model of skin inflammation in humans leads to a rapid and reproducible increase in the interferon response signature: a potential translational model for drug development. INFLAMMATION RESEARCH 64:171-183(2015).
    Troseid, M; Nestvold, TK; et al. Soluble CD14 Is Associated with Markers of Vascular Dysfunction in Bariatric Surgery Patients. METABOLIC SYNDROME AND RELATED DISORDERS 13:119-124(2015).

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