Cd14

  • Official Full Name

    CD14 molecule

  • Overview

    The protein encoded by this gene is a component of the innate immune system. CD14 exists in two forms. Either it is anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 KDa) or is directly secreted from intracellular vesicles (56 KDa). CD14 takes its name from its inclusion in the cluster of differentiation group of cell surface marker proteins. CD14 was the first described pattern recognition receptor.
  • Synonyms

    CD14; monocyte differentiation antigen CD14; OTTHUMP00000159892; OTTHUMP00000223710; OTTHUMP00000223711; OTTHUMP00000224328; myeloid cell-specific leucine-rich glycoprotein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chromatography Reagents
  • Others
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • CHO
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Fc
  • hFc
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • mFc
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD14-264H Active Recombinant Human CD14 protein CHO N/A Thr20-Cys352
Human CD14-90H Active Recombinant Human CD14 HEK293 N/A
Human CD14-2100H Active Recombinant Human CD14 protein CHO N/A
Human CD14-2109H Active Recombinant Human CD14 protein, His-tagged HEK293 His Met 1-Met 344
Human CD14-102H Active Recombinant Human CD14 protein, His-tagged HEK293 His Met1-Met344
Human CD14-28H Recombinant Human CD14, His-tagged HEK293 His
Human CD14-613H Recombinant Human CD14 protein, hFc-tagged HEK293 hFc Thr20-Cys352
Human CD14-789H Recombinant Human CD14 protein, His-tagged E.coli His Asp125~Leu288 (Accession # P08571)
Human CD14-204H Recombinant Human CD14, His-tagged E.coli His 20- 349aa
Human CD14-0721H Recombinant Human CD14 Protein, GST-Tagged Wheat Germ GST
Human CD14-1604HCL Recombinant Human CD14 cell lysate Human Cell N/A
Human CD14-6224H Recombinant Human CD14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD14-1211HFL Recombinant Full Length Human CD14 Protein, C-Flag-tagged Mammalian cells Flag
Human CD14-650H Recombinant Human CD14 Protein, His-tagged E.coli N-His Thr20-Leu368
Human CD14-649H Recombinant Human CD14 Protein, His-tagged HEK293F N-His Thr20-Ala297
Human CD14-151H Recombinant Human CD14 Protein, His-tagged Human cells His
Human CD14-284H Active Recombinant Human CD14 protein, His-tagged HEK293 His Met1-Ala375
Human CD14-3008H Recombinant Human CD14 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD14-179H Recombinant Human CD14 Protein, C-His-tagged E.coli C-His
Human CD14-2658H Recombinant Human CD14 protein, GST-tagged E.coli GST 20-345aa
Human CD14-4823H Active Recombinant Human CD14 protein, mFc-tagged HEK293 mFc Met1-Ala375
Human CD14-5896H Recombinant Human CD14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD14-486H Active Recombinant Human CD14 protein, hFc-tagged HEK293 hFc Met1-Ala375
Human CD14-651H Recombinant Human CD14 Protein, His-tagged HEK293F N-His Thr20-Ala83
Human CD14-123H Recombinant Human CD14 Protein, His-tagged HEK293 His 375
Human CD14-4993H Recombinant Human CD14 protein, His-tagged HEK293 His 20-345aa
Human CD14-5032M CD14 protein-coupled magnetic MicroBeads
Human CD14-652H Recombinant Human CD14 Protein, His-tagged HEK293F N-His Thr20-Asn345
Human CD14-124H Recombinant Human CD14 Protein, Fc-tagged HEK293 Fc 375
Human CD14-2944HF Recombinant Full Length Human CD14 Protein, GST-tagged In Vitro Cell Free System GST 375 amino acids
Human CD14-8612M Whole Blood CD14 protein-coupled magnetic MicroBeads
Human CD14-530H Recombinant Human CD14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD14-157H Recombinant Human CD14 Protein, Fc-tagged HEK293 Fc 375
Human CDA069P Recombinant Human CD14 E.coli N/A
Human CD14-2913M Leukopak CD14 protein-coupled magnetic MicroBeads
Human CD14-9653M LRSC CD14 protein-coupled magnetic MicroBeads
Human CD14-530H-B Recombinant Human CD14 Protein Pre-coupled Magnetic Beads HEK293
Human CD14-1291H Recombinant Human CD14 Protein (Thr20-Leu368), His tagged E.coli His Thr20-Leu368
Human CD14-305M CD14 protein-coupled magnetic MicroBeads
Human CD14-5308H Recombinant Human CD14 Protein (Met1-Met344), C-His tagged Mammalian cells C-His Met1-Met344
Human CD14-5309H Recombinant Human CD14 Protein (Met1-Ala83), C-His tagged Mammalian cells C-His Met1-Ala83
Human CD14-5311H Recombinant Human CD14 Protein (Met1-Ala83), C-Fc tagged Mammalian cells C-Fc Met1-Ala83
Human CD14-6043M Buffy Coat CD14 protein-coupled magnetic MicroBeads
Mouse Cd14-117M Active Recombinant Mouse Cd14 Protein, Fc-tagged Mammalian cells Fc
Mouse Cd14-118M Active Recombinant Mouse Cd14, His-tagged CHO His
Mouse Cd14-3318M Recombinant Mouse Cd14 protein(Met1-Pro345), His&hFc-tagged HEK293 C-His&hFc Met1-Pro345
Mouse Cd14-1711M Recombinant Mouse CD14 Antigen Mammalian cells N/A
Mouse Cd14-1385M Recombinant Mouse Cluster Of Differentiation 14, His-tagged CHO His
Mouse Cd14-2270M Recombinant Mouse Cd14 protein(Met1-Pro345), His-tagged HEK293 C-His Met1-Pro345
Mouse Cd14-58M Recombinant Mouse Cd14 protein, His-tagged Insect Cell His
Mouse CD14-2581MCL Recombinant Mouse CD14 cell lysate Human Cell N/A
Mouse Cd14-7M-B Recombinant Mouse Cd14 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cd14-648M Recombinant Mouse Cd14 Protein, His-tagged E.coli N-His Ser16-Val366
Mouse Cd14-810M Recombinant Mouse Cd14 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Cd14-7M Recombinant Mouse Cd14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Cd14-7484R Recombinant Rat Cd14 protein(Met1-Tyr341), hFc-tagged HEK293 C-hFc Met1-Tyr341
Rat Cd14-791R Recombinant Rat Cd14 protein, His & GST-tagged E.coli His/GST Ser18~Val372 (Accession # Q63691)
Rat CD14-1235R Recombinant Rat CD14 Protein Mammalian Cell His
Rat CD14-1101R Recombinant Rat CD14 Protein, His-tagged HEK293 His
Rat CD14-1469RCL Recombinant Rat CD14 cell lysate Human Cell N/A
Rat CD14-893R-B Recombinant Rat CD14 Protein Pre-coupled Magnetic Beads HEK293
Rat CD14-893R Recombinant Rat CD14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CD14-8847C Recombinant Cynomolgus CD14, His tagged Human Cell His
Cynomolgus Monkey CD14-1169CCL Recombinant Cynomolgus CD14 cell lysate Human Cell N/A
Rhesus Macaque CD14-717R Recombinant Rhesus monkey CD14 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CD14-544R Recombinant Rhesus Macaque CD14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CD14-544R-B Recombinant Rhesus Macaque CD14 Protein Pre-coupled Magnetic Beads HEK293
Pig CD14-790P Recombinant Pig CD14 protein, His & T7-tagged E.coli His/T7 Thr21~Ala373 (Accession # A2SW51)
Chicken CD14-3887C Recombinant Chicken CD14 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

Cd14 involved in several pathways and played different roles in them. We selected most pathways Cd14 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cd14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwaySTMN1B;CDC42L;GNA12;RPS6KA5;CACNA2D1A;MAP3K5;RPS6KA3;CACNB3A;AKT3A
NF-kappa B signaling pathwayCD14;PLCG2;BTK;CFLAR;BIRC3;TNFSF13B;TNFRSF11A;BLNK;DDX58
PhagosomeC3A.3;TLR4;SEC22BA;STX12;VAMP3;THBS3A;NCF1;ITGB2L;HLA-DPB1
Toll-like receptor signaling pathwayTLR4;IL8L1;NFKB1;TAB2;PIK3R5;CD14;CCL5;PIK3CD;IFNA16
Hematopoietic cell lineageIL1B;CD14;ANPEP;CD8A;CSF1R;HLA-DRA;CD3G;CD1A;Flt3l
Regulation of actin cytoskeletonBDKRB1;PIP4K2A;RAC1;ROCK2B;VAV1;FGD;INSRR;BRAF;PDGFA
Pathogenic Escherichia coli infectionNCK1;TUBA1A;NCL;CDC42;CTTN;TUBAL3;ROCK2;TUBA1B;NCK2
Salmonella infectionWASLB;PKN3;CDC42L2;MAPK14B;PFN2;KLC4;MAPK10;WAS;PYCARD
PertussisC4BPB;NLRP3;TNF;TLR4;C1R;MAPK3;SERPING1;LY96;CFL2
LegionellosisNLRC4;Casp3;IL18;SAR1B;IL1B;RAB1B;CXCL1;HSPD1;NAIP7
AmoebiasisC9;LAMA2;COL4A4;ACTN2;SERPINB10;GNAL;CD1d1;IL-8;ACTN1
TuberculosisATP6V0B;IL1B;CALML3;FCGR1A;CD209C;Ifna15;H2-AA;CORO1A;PPP3CA
Transcriptional misregulation in cancerETV1;DEFA3;ETV4;PTCRA;PLAT;HIST2H3C2;ERG;PRCC;MEIS1

Cd14 has several biochemical functions, for example, lipopolysaccharide binding, lipoteichoic acid binding, opsonin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cd14 itself. We selected most functions Cd14 had, and list some proteins which have the same functions with Cd14. You can find most of the proteins on our site.

Function Related Protein
lipopolysaccharide bindingBPIFC;SCARB1;CD6;CATHL3;TRIL;KIAA0644;HSPD1;LBP;SELP
lipoteichoic acid bindingCD6;TLR2;CD14;TREM2;LBP
opsonin receptor activity
peptidoglycan receptor activityPGLYRP3;PGLYRP1;PGLYRP2;CD14;PGLYRP4
protein bindingZNF664-FAM101A;EIF3B;TRPC4;ZNF286A;KRT7;PRSS3;SNX12;STARD3;C7orf42

Cd14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cd14 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cd14.

FSTL1; IRAK3; DIP2A; TNFRSF1B; GJB2; POLR2J; PPP3R2; ARFGAP3; PHF20L1; b4dt77_human; TAF1; PPP1R12B; BUB1B; SVIL; OASL; TAF9; ARID2

Research Area

Related articles

Dickson, MC; Ludbrook, VJ; et al. A model of skin inflammation in humans leads to a rapid and reproducible increase in the interferon response signature: a potential translational model for drug development. INFLAMMATION RESEARCH 64:171-183(2015).
Troseid, M; Nestvold, TK; et al. Soluble CD14 Is Associated with Markers of Vascular Dysfunction in Bariatric Surgery Patients. METABOLIC SYNDROME AND RELATED DISORDERS 13:119-124(2015).
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