Cd14

  • Official Full Name

    CD14 molecule

  • Overview

    The protein encoded by this gene is a component of the innate immune system. CD14 exists in two forms. Either it is anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 KDa) or is directly secreted from intracellular vesicles (56 KDa). CD14 takes its name from its inclusion in the cluster of differentiation group of cell surface marker proteins. CD14 was the first described pattern recognition receptor.
  • Synonyms

    CD14; monocyte differentiation antigen CD14; OTTHUMP00000159892; OTTHUMP00000223710; OTTHUMP00000223711; OTTHUMP00000224328; myeloid cell-specific leucine-rich glycoprotein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chromatography Reagents
  • Others
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus Macaque
  • CHO
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Fc
  • hFc
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • mFc
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD14-264H Active Recombinant Human CD14 protein CHO N/A
Human CD14-90H Active Recombinant Human CD14 HEK293 N/A
Human CD14-2100H Active Recombinant Human CD14 protein CHO N/A
Human CD14-102H Active Recombinant Human CD14 protein, His-tagged HEK293 His
Human CD14-28H Recombinant Human CD14, His-tagged HEK293 His
Human CD14-613H Recombinant Human CD14 protein, hFc-tagged HEK293 hFc
Human CD14-789H Recombinant Human CD14 protein, His-tagged E.coli His
Human CD14-204H Recombinant Human CD14, His-tagged E.coli His
Human CD14-0721H Recombinant Human CD14 Protein, GST-Tagged Wheat Germ GST
Human CD14-1604HCL Recombinant Human CD14 cell lysate Human Cell N/A
Human CD14-2109H Active Recombinant Human CD14 protein, His-tagged HEK293 His
Human CD14-1211HFL Recombinant Full Length Human CD14 Protein, C-Flag-tagged Mammalian cells Flag
Human CD14-650H Recombinant Human CD14 Protein, His-tagged E.coli N-His
Human CD14-649H Recombinant Human CD14 Protein, His-tagged HEK293F N-His
Human CD14-6224H Recombinant Human CD14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD14-284H Active Recombinant Human CD14 protein, His-tagged HEK293 His
Human CD14-3008H Recombinant Human CD14 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD14-179H Recombinant Human CD14 Protein, C-His-tagged E.coli C-His
Human CD14-151H Recombinant Human CD14 Protein, His-tagged Human cells His
Human CD14-4823H Active Recombinant Human CD14 protein, mFc-tagged HEK293 mFc
Human CD14-5896H Recombinant Human CD14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD14-486H Active Recombinant Human CD14 protein, hFc-tagged HEK293 hFc
Human CD14-2658H Recombinant Human CD14 protein, GST-tagged E.coli GST
Human CD14-123H Recombinant Human CD14 Protein, His-tagged HEK293 His
Human CD14-4993H Recombinant Human CD14 protein, His-tagged HEK293 His
Human CD14-5032M CD14 protein-coupled magnetic MicroBeads
Human CD14-651H Recombinant Human CD14 Protein, His-tagged HEK293F N-His
Human CD14-124H Recombinant Human CD14 Protein, Fc-tagged HEK293 Fc
Human CD14-652H Recombinant Human CD14 Protein, His-tagged HEK293F N-His
Human CD14-8612M Whole Blood CD14 protein-coupled magnetic MicroBeads
Human CD14-2944HF Recombinant Full Length Human CD14 Protein, GST-tagged In Vitro Cell Free System GST
Human CD14-157H Recombinant Human CD14 Protein, Fc-tagged HEK293 Fc
Human CD14-530H Recombinant Human CD14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD14-2913M Leukopak CD14 protein-coupled magnetic MicroBeads
Human CDA069P Recombinant Human CD14 E.coli N/A
Human CD14-530H-B Recombinant Human CD14 Protein Pre-coupled Magnetic Beads HEK293
Human CD14-9653M LRSC CD14 protein-coupled magnetic MicroBeads
Human CD14-1291H Recombinant Human CD14 Protein (Thr20-Leu368), His tagged E.coli His
Human CD14-305M CD14 protein-coupled magnetic MicroBeads
Human CD14-5308H Recombinant Human CD14 Protein (Met1-Met344), C-His tagged Mammalian cells C-His
Human CD14-5309H Recombinant Human CD14 Protein (Met1-Ala83), C-His tagged Mammalian cells C-His
Human CD14-5311H Recombinant Human CD14 Protein (Met1-Ala83), C-Fc tagged Mammalian cells C-Fc
Human CD14-6043M Buffy Coat CD14 protein-coupled magnetic MicroBeads
Mouse Cd14-118M Active Recombinant Mouse Cd14, His-tagged CHO His
Mouse Cd14-3318M Recombinant Mouse Cd14 protein(Met1-Pro345), His&hFc-tagged HEK293 C-His&hFc
Mouse Cd14-1711M Recombinant Mouse CD14 Antigen Mammalian cells N/A
Mouse Cd14-1385M Recombinant Mouse Cluster Of Differentiation 14, His-tagged CHO His
Mouse Cd14-117M Active Recombinant Mouse Cd14 Protein, Fc-tagged Mammalian cells Fc
Mouse Cd14-2270M Recombinant Mouse Cd14 protein(Met1-Pro345), His-tagged HEK293 C-His
Mouse Cd14-58M Recombinant Mouse Cd14 protein, His-tagged Insect Cell His
Mouse CD14-2581MCL Recombinant Mouse CD14 cell lysate Human Cell N/A
Mouse Cd14-7M-B Recombinant Mouse Cd14 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cd14-648M Recombinant Mouse Cd14 Protein, His-tagged E.coli N-His
Mouse Cd14-810M Recombinant Mouse Cd14 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Cd14-7M Recombinant Mouse Cd14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Cd14-7484R Recombinant Rat Cd14 protein(Met1-Tyr341), hFc-tagged HEK293 C-hFc
Rat Cd14-791R Recombinant Rat Cd14 protein, His & GST-tagged E.coli His/GST
Rat CD14-1235R Recombinant Rat CD14 Protein Mammalian Cell His
Rat CD14-1101R Recombinant Rat CD14 Protein, His-tagged HEK293 His
Rat CD14-1469RCL Recombinant Rat CD14 cell lysate Human Cell N/A
Rat CD14-893R-B Recombinant Rat CD14 Protein Pre-coupled Magnetic Beads HEK293
Rat CD14-893R Recombinant Rat CD14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CD14-8847C Recombinant Cynomolgus CD14, His tagged Human Cell His
Cynomolgus Monkey CD14-1169CCL Recombinant Cynomolgus CD14 cell lysate Human Cell N/A
Rhesus Macaque CD14-717R Recombinant Rhesus monkey CD14 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CD14-544R Recombinant Rhesus Macaque CD14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CD14-544R-B Recombinant Rhesus Macaque CD14 Protein Pre-coupled Magnetic Beads HEK293
Pig CD14-790P Recombinant Pig CD14 protein, His & T7-tagged E.coli His/T7
Chicken CD14-3887C Recombinant Chicken CD14 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Cd14 Related Articles
  • Cd14 Related Research Area

Cd14 involved in several pathways and played different roles in them. We selected most pathways Cd14 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cd14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayFGF7;GADD45AB;RAC1A;CACNG7;CACNB4;RPS6KA3;Casp3;ARR3B;C11orf52
NF-kappa B signaling pathwayTNFSF11;PLAU;LTBR;LTB;CD40;TNFRSF13C;XIAP;TLR4;CCL21
PhagosomeTUBAL3;ITGB3;MRC2;MARCO;TLR2-2;NOX1;ATP6V0A4;THBS3;Itgam&Itgb2
Toll-like receptor signaling pathwayMAPK12B;CXCL8B.3;CCL5;IFNA21;IL12B;IRF5;IFNA5;LBP;IL12A
Hematopoietic cell lineageITGA2B;CD38;CD1E, B2M;IL3RA;CSF1R;CD14;CD34;GM-CSF;ITGA4
Regulation of actin cytoskeletonGSNB;GNA12;MYL12.1;ACTN3;PIP5K1AA;FGF6A;ACTB1;ARAF;MAP2K2
Pathogenic Escherichia coli infectionTUBAL3;RHOA;CDC42;CTTN;NCL;EZR;YWHAZ;TUBA1A;NCK2
Salmonella infectionMAPK11;MAPK8A;IFNG1-2;ACTB2;MAPK1;CCL3L1;RAB7B;FOS;MAPK10
PertussisCALM2;IRF8;Casp3;C1QC;IL-8;MAPK9;MYD88;ITGB2;CXCL6
LegionellosisTLR5;IL18;Casp3;CLK1;HSPA1B;TLR2;TNF;SAR1A;HSPA1L
AmoebiasisIL1B2;LAMC3;SERPINB1B;COL27A1;VCL;SERPINB13;TGFB3;CD1D;COL4A4
TuberculosisNFYA;CASP8;PLK3;CD209C;Itgam&Itgb2;Ifna11;IL10RB;ATP6V0B;cgr2b
Transcriptional misregulation in cancerID2;FUS;RUNX1;ZBTB16;H3F3A;ARNT2;Pdgfa&Pdgfb;GOLPH3;LMO2

Cd14 has several biochemical functions, for example, lipopolysaccharide binding, lipoteichoic acid binding, opsonin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cd14 itself. We selected most functions Cd14 had, and list some proteins which have the same functions with Cd14. You can find most of the proteins on our site.

Function Related Protein
lipopolysaccharide bindingBPIFC;BPIFA2;SCARB1;PTAFR;P2RX7;TRIL;DROSHA;HSPD1;PSMB4
lipoteichoic acid bindingCD6;TREM2;CD14;LBP;TLR2
opsonin receptor activity
peptidoglycan receptor activityPGLYRP1;PGLYRP4;PGLYRP2;CD14;PGLYRP3
protein bindingRCN1;CRLF1;VAPB;CAML;ZNF143;FBXL5;ACOT8;CCNT1;CRY1A

Cd14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cd14 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cd14.

FSTL1; IRAK3; DIP2A; TNFRSF1B; GJB2; POLR2J; PPP3R2; ARFGAP3; PHF20L1; b4dt77_human; TAF1; PPP1R12B; BUB1B; SVIL; OASL; TAF9; ARID2

Dickson, MC; Ludbrook, VJ; et al. A model of skin inflammation in humans leads to a rapid and reproducible increase in the interferon response signature: a potential translational model for drug development. INFLAMMATION RESEARCH 64:171-183(2015).
Troseid, M; Nestvold, TK; et al. Soluble CD14 Is Associated with Markers of Vascular Dysfunction in Bariatric Surgery Patients. METABOLIC SYNDROME AND RELATED DISORDERS 13:119-124(2015).
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