Cd14
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Official Full Name
CD14 molecule
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Background
The protein encoded by this gene is a component of the innate immune system. CD14 exists in two forms. Either it is anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 KDa) or is directly secreted from intracellular vesicles (56 KDa). CD14 takes its name from its inclusion in the cluster of differentiation group of cell surface marker proteins. CD14 was the first described pattern recognition receptor. -
Synonyms
CD14; monocyte differentiation antigen CD14; OTTHUMP00000159892; OTTHUMP00000223710; OTTHUMP00000223711; OTTHUMP00000224328; myeloid cell-specific leucine-rich glycoprotein;
- Involved Pathway
- Protein Function
- Interacting Protein
- Cd14 Related Articles
- Cd14 Related Research Area
Cd14 involved in several pathways and played different roles in them. We selected most pathways Cd14 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cd14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | CACNA2D2;CACNB3;RELB;MAP3K5;IKBKB;IL1R1;RASA2;MAPKAPK2;PRKACG |
| NF-kappa B signaling pathway | IRAK4;NFKB1;MYD88;TRIM25;LRDD;Bcl2a1b;LYN;PRKCQ;LAT |
| Phagosome | TUBA1L2;ATP6V1G1;SEC22BA;TLR2;C3;RAB5C;ITGB1B.2;HLA-F;CD14 |
| Toll-like receptor signaling pathway | FOS;MAP2K2B;TRAF6;CXCL9;TLR5;Ifna15;MAPK8;TLR3;LBP |
| Hematopoietic cell lineage | IL6R;CD1C;CD59;CD8B1;Kitl;CD59A;CD1E;ITGA5;Itgam&Itgb2 |
| Regulation of actin cytoskeleton | PIP5KL1;ITGB1B.2;FGF6B;ARHGEF7;PAK2A;ITGB5;FGF1B;PDGFB;ACTG1 |
| Pathogenic Escherichia coli infection | TUBA1C;PRKCA;TUBA1A;NCK1;TLR4;KRT18;FYN;CDC42;YWHAZ |
| Salmonella infection | RELA;IL6;TJP1;RHOG;MAPK8A;ACTB1;PKN2;CCL3L1;CDC42L |
| Pertussis | MAPK11;ITGB2L;C1R;ITGAM;ITGB1;TLR4;FOS;CALM2;IL12B |
| Legionellosis | SAR1A;CXCL2;SEC22B;NLRC4;CASP8;RAB1;MYD88;CD14;NFKB2 |
| Amoebiasis | COL1A2;LAMB3;COL4A1;SERPINB1C;GNAS;PIK3CG;COL4A3;ADCY1;LAMC2 |
| Tuberculosis | AKT2;TLR2;CAMP;Ifna11;HLA-DRB5;IFNA8;ATP6V0C;HLA-DPB1;IL12B |
| Transcriptional misregulation in cancer | PLAT;HOXA11;ITGB7;HMGA2;PER2;PTK2;CCNT1;IGF1R;EWSR1 |
Cd14 has several biochemical functions, for example, lipopolysaccharide binding, lipoteichoic acid binding, opsonin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cd14 itself. We selected most functions Cd14 had, and list some proteins which have the same functions with Cd14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipopolysaccharide binding | RNASE7;BPIFA2;HMGB1;TRIL;DROSHA;TREM2;SPON2;PTAFR;BPI |
| lipoteichoic acid binding | TREM2;CD14;TLR2;CD6;LBP |
| opsonin receptor activity | |
| peptidoglycan receptor activity | PGLYRP3;PGLYRP2;CD14;PGLYRP4;PGLYRP1 |
| protein binding | GRIFIN;CNOT7;CRELD2;DHX15;SIRT7;CHEK2;TTK;CCDC155;TUBB2B |
Cd14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cd14 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cd14.
FSTL1; IRAK3; DIP2A; TNFRSF1B; GJB2; POLR2J; PPP3R2; ARFGAP3; PHF20L1; b4dt77_human; TAF1; PPP1R12B; BUB1B; SVIL; OASL; TAF9; ARID2
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