• Official Full Name

    CD59 molecule, complement regulatory protein

  • Overview

    This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    CD59; CD59 molecule, complement regulatory protein; 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20; CD59 glycoprotein; protectin; 1F5 antigen; MEM43 antigen; Ly-6-like protein; T cell-activating protein; human leukocyte antigen MIC11; lymphocytic antigen CD59/MEM43; 20 kDa homologous restriction factor; membrane inhibitor of reactive lysis; membrane attack complex inhibition factor; membrane attack complex (MAC) inhibition factor; surface anitgen recognized by monoclonal antibody 16.3A5; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Pig
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • hFc
  • His
  • Fc|His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|S
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD59-1600H Active Recombinant Human CD59, His-tagged Mammalian cells His
Human CD59-3977H Recombinant Human CD59, His tagged HEK293 His Met 1-Glu 101
Human CD59-15902H Recombinant Human CD59, His-tagged E.coli His 26-102 aa
Human CD59-76H Recombinant Human CD59 protein, T7/His-tagged E.coli T7/His
Human CD59-0836H Recombinant Human CD59 Protein, GST-Tagged Wheat Germ GST
Human CD59-1968HCL Recombinant Human CD59 cell lysate Human Cell N/A
Human CD59-3001H Recombinant Human CD59 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Leu 26-Asn 102
Human CD59-151H Recombinant Human CD59 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human CD59-5370H Recombinant Human CD59 protein, His-tagged Yeast His 26-102aa
Human CD59-2667H Recombinant Human CD59 protein, GST-tagged E.coli GST 26-102aa
Human CD59-3116H Recombinant Human CD59 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD59-202H Recombinant Human CD59 Protein, C-His-tagged E.coli C-His
Human CD59-3013HF Recombinant Full Length Human CD59 Protein, GST-tagged In Vitro Cell Free System GST 128 amino acids
Human CD59-692H Recombinant Human CD59 Protein, His and C-hFc-tagged HEK293F N-His and C-hFc Leu26-Asn102
Human CD59-5367H Recombinant Human CD59 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD59-693H Recombinant Human CD59 Protein, His-tagged HEK293F N-His Leu26-Asn102
Human CD59-1539HFL Recombinant Full Length Human CD59 Protein, C-Flag-tagged Mammalian cells Flag
Human CD59-5362H Recombinant Human CD59 Protein (Met1-Glu101), C-His tagged Mammalian cells C-His Met1-Glu101
Human CD59-543H Recombinant Human CD59 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD59-543H-B Recombinant Human CD59 Protein Pre-coupled Magnetic Beads HEK293
Human CD59-0955H Recombinant Human CD59 Protein (Leu26-Asn102), GST tagged E.coli GST Leu26-Asn102
Rat Cd59-6831R Recombinant Rat Cd59 protein, His & S-tagged E.coli His/S Leu23~Ser105 (Accession # P27274)
Rat Cd59-8765R Recombinant Rat CD59 protein(Met1-Asn100), His-tagged HEK293 C-His Met1-Asn100
Rat Cd59-8764R Recombinant Rat Cd59 protein(Met1-Asn100), hFc-tagged HEK293 C-hFc Met1-Asn100
Rat CD59-1260R Recombinant Rat CD59 Protein Mammalian Cell His
Rat CD59-1365RCL Recombinant Rat CD59 cell lysate Human Cell N/A
Rat CD59-918R-B Recombinant Rat CD59 Protein Pre-coupled Magnetic Beads HEK293
Rat CD59-918R Recombinant Rat CD59 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus monkey CD59-6833R Recombinant Rhesus monkey CD59 protein, His & S-tagged E.coli His/S His21~Leu107 (Accession # Q8SQ46)
Rabbit CD59-6832R Recombinant Rabbit CD59 protein, His & S-tagged E.coli His/S Ser25~Leu104 (Accession # O77541)
Cynomolgus CD59-392C Recombinant Cynomolgus CD59 protein(Met1-Glu101), His-tagged HEK293 C-His Met1-Glu101
Cynomolgus Monkey CD59-97C Recombinant Cynomolgus CD59, His tagged Human Cell Fc/His
Cynomolgus Monkey CD59-1019CCL Recombinant Cynomolgus CD59 cell lysate Human Cell N/A
Cynomolgus Monkey CD59-140C Recombinant Cynomolgus Monkey CD59 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CD59-140C-B Recombinant Cynomolgus Monkey CD59 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CD59-746R Recombinant Rhesus monkey CD59 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CD59-572R-B Recombinant Rhesus Macaque CD59 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CD59-572R Recombinant Rhesus Macaque CD59 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Pig CD59-6830P Recombinant Pig CD59 protein, His & T7-tagged E.coli His/T7 Leu26~Ser98 (Accession # O62680)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CD59 involved in several pathways and played different roles in them. We selected most pathways CD59 participated on our site, such as Complement and coagulation cascades, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD59 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesF2;Hc;C8A;SERPINE1;KNG1;CR1;F12;VWF;MBL1
Hematopoietic cell lineageMS4A1;CD1C;CD1d1;CD1E;HLA-DRB1;CD7;Flt3l;HLA-DRB3;Il4ra

CD59 has several biochemical functions, for example, complement binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD59 itself. We selected most functions CD59 had, and list some proteins which have the same functions with CD59. You can find most of the proteins on our site.

Function Related Protein
complement bindingCFB;CD59;CR2;C8G;C8A;CD46

CD59 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD59 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD59.

TMED10; TMED2; C; EGFR; ganglioside_gm1; SMAD4; q7cgd4_yerpe; b3xyc5_sollc; ATP6AP2; CFTR

Research Area

Related articles

Shi, H; Williams, J; et al. Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. APOPTOSIS 20:433-443(2015).
Ahmed, S; Kemp, MW; et al. Comparison of Complement Activity in Adult and Preterm Sheep Serum. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 73:232-241(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
How to explain the role of CD59 in hemolytic disease? 11/30/2022

In hemolytic diseases, the deficiency or dysfunction of CD59 may lead to excessive lysis of red blood cells because the formation of the complement C5b-9 complex cannot be effectively prevented.

Are there differences in CD59 expression levels in different types of cells? 09/30/2022

Yes, the expression level of CD59 can vary in different cell types. In general, it is expressed higher in blood cells and some tumor cells.

What are some of the technical challenges that laboratories may encounter when researching CD59? 12/03/2021

When researching CD59, laboratories may encounter technical challenges such as selecting the appropriate assay, ensuring the quality and consistency of samples, and the complexity of interpreting results. In addition, CD59 expression variations in different cell types and experimental conditions need to be considered.

What diseases are associated with aberrant expression of CD59? 07/19/2020

Aberrant expression of CD59 has been associated with a variety of diseases, including but not limited to hemolytic diseases, certain types of cancer, and autoimmune diseases.

How can I measure CD59 expression in the laboratory? 06/17/2020

CD59 expression can be detected using flow cytometry, immunofluorescence staining, or western blotting.

Is there a current treatment for CD59? 01/01/1900

The current treatment for CD59 is still in the research stage, and there is no drug approved for clinical use. However, some studies are exploring the use of gene therapy or antibody therapy to modulate CD59 expression or function.

Customer Reviews (3)

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    The quality is very high and the reliability is very helpful for our research results.


      There are no doping impurities, the experimental effect is very good, and I will recommend it to other students.


        Easy to operate and cost-effective.

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