cdh4

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cdh4

Official Full Name cadherin 4, type 1, R-cadherin (retinal)
Background This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene.
Synonyms CDH4; cadherin 4, type 1, R-cadherin (retinal); cadherin-4; R Cadherin; R-CAD; R-cadherin; retinal cadherin; cadherin 4, type 1, preproprotein; CAD4; RCAD; FLJ22202; FLJ40547; MGC126700; MGC138355
    • Species :
    • Chicken
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDH4-0990H Recombinant Human CDH4 Protein, GST-Tagged Wheat Germ GST
    Human CDH4-2723HCL Recombinant Human CDH4 cell lysate Human Cell N/A
    Human CDH4-601H Recombinant Human CDH4, His tagged Human Cell His
    Human CDH4-610H Recombinant Human CDH4 Protein, His/GST-tagged E.coli His/GST
    Chicken CDH4-1210C Recombinant Chicken CDH4 Mammalian Cell His
    Zebrafish CDH4-4271Z Recombinant Zebrafish CDH4 Mammalian Cell His
    Zebrafish CDH4-8712Z Recombinant Zebrafish CDH4 Mammalian Cell His

    cdh4 involved in several pathways and played different roles in them. We selected most pathways cdh4 participated on our site, such as Adherens junctions interactions, CDO in myogenesis, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with cdh4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adherens junctions interactions CDH2; PVRL1A; CDH9; CTNNA1; PTBP3; CDH24; CDH18A; CDH10A; CTNNB1; CDH10
    CDO in myogenesis MEF2B; CTNNA2; BOC; TCF3B; CDH4; MEF2AA; BNIP2; MYOD1; CDON; TCF3A
    Cell adhesion molecules (CAMs) CD34; CDH2; CLDN11B; SELPLG; ITGA4; CD80; HLA-DPA1; ITGA6B; NRXN3A; CADM3
    Cell junction organization FBLIM1; CLDN23; CDH7; RSU1; FERMT2; CTNND1; ITGB1B.1; ANG; PVRL1A; CDH18
    Cell-Cell communication CDH5; COL17A1; CLDN7; PARVB; DSCAM; CLDN16; CADM2A; CLDN23; CDH24; CDH11
    Cell-cell junction organization CLDN4; CLDN16; PVRL2L; CDH17; CDH7; CDH13; ANG; CLDN7; CTNND1; CDH18A
    Developmental Biology EFNA3; SREBF2; MED20; CTNNA2; KIF4A; FGF8B; NRTN; EFNB3; CSNK2A2; LEFTY1
    Myogenesis TCF3B; BOC; BNIP2; MYOG; TCF12; CDH4; MEF2B; TCF4; CDON; TCF3A

    cdh4 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cdh4 itself. We selected most functions cdh4 had, and list some proteins which have the same functions with cdh4. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding THBS3B; CALB2B; OTOFA; CAPN2L; PRRG1; C1R; MMP1A; SWAP70B; BMP1B; MICU1

    cdh4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cdh4 here. Most of them are supplied by our site. Hope this information will be useful for your research of cdh4.

    Dlg4

    AZZI, L; MEIJER, L; et al. PURIFICATION OF A 15-KDA CDK4-BINDING AND CDK5-BINDING PROTEIN. JOURNAL OF BIOLOGICAL CHEMISTRY 269:13279-13288(1994).

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