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CDKN1C

Official Full Name

cyclin-dependent kinase inhibitor 1C (p57, Kip2)
Overview

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.
Synonyms

CDKN1C; cyclin-dependent kinase inhibitor 1C (p57, Kip2); BWS; WBS; p57; BWCR; KIP2; cyclin-dependent kinase inhibitor 1C; p57Kip2; cyclin-dependent kinase inhibitor p57; P57; OTTHUMP- 00000011736; OTTHUMP00000011738; Beckwith- Wiedemann syndrome; OTTHUMP00000229152;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CDKN1C-30575TH	Recombinant Human CDKN1C	Wheat Germ	N/A	100 amino acids	Inquiry
Human	CDKN1C-1059H	Recombinant Human CDKN1C Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CDKN1C-11061H	Recombinant Human CDKN1C, His-tagged	E.coli	His	1-316a.a.	$319 / 25ug
Mouse	CDKN1C-3222M	Recombinant Mouse CDKN1C Protein	Mammalian Cell	His		Inquiry
Mouse	CDKN1C-1536M-B	Recombinant Mouse CDKN1C Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	CDKN1C-1536M	Recombinant Mouse CDKN1C Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	CDKN1C-275Z	Recombinant Zebrafish CDKN1C	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CDKN1C Related Research Area

CDKN1C involved in several pathways and played different roles in them. We selected most pathways CDKN1C participated on our site, such as Cell cycle, Endochondral Ossification, G1 to S cell cycle control, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell cycle	NCAPD3;GADD45G;BRE;CDK4;FZR1A;CENPN;MPEG1;RAD9;CSNK1E
Endochondral Ossification	SOX5;CTSL2;COL10A1A;MMP13;IFT88;ADAMTS1;PTH;MGP;ADAMTS5
G1 to S cell cycle control	E2F6;MYT1;CDKN1C;TFDP1B;ATF6B

CDKN1C has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN1C itself. We selected most functions CDKN1C had, and list some proteins which have the same functions with CDKN1C. You can find most of the proteins on our site.

Function	Related Protein
cyclin-dependent protein serine/threonine kinase inhibitor activity	CDKN1B;CDKN1D;HEXIM2;CDKN2B;CDKN1BA;CDKN2C;Casp3;CDKN1A;HEXIM1
protein binding	FOXP4;EIF4B;AVPI1;AGO1;PTPRO;AHNAK2;NUP155;NOS3;TRDN

CDKN1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN1C here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN1C.

CDK2; MCM7; FBXL12; Cdk1; CDK4; PCNA; CCNE2

CKIs(Cyclin Dependent Kinase Inhibitors)