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Official Full Name centrosomal protein 290kDa
Background This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer.
Synonyms CEP290; centrosomal protein 290kDa; centrosomal protein of 290 kDa; 3H11Ag; BBS14; cancer/testis antigen 87; CT87; FLJ13615; JBTS5; Joubert syndrome 5; KIAA0373; LCA10; Meckel syndrome; type 4; MKS4; nephrocystin 6; NPHP6; POC3; POC3 centriolar protein homolog (Chlamydomonas); rd16; SLSN6; Bardet-Biedl syndrome 14 protein; CE290_HUMAN; CTCL tumor antigen se2 2; FLJ21979; JBTS6; Meckel syndrome, type 4; Monoclonal 3H11 antigen; Nephrocystin-6; POC3 centriolar protein homolog; Prostate cancer antigen T21; SLSN6 1, 2, 5; Tumor antigen se2-2; nephrocytsin-6; OTTHUMP00000242341; CTCL tumor antigen se2-2
    • Species :
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CEP290-11112H Recombinant Human CEP290, His-tagged E.coli His
    Human CEP290-1134H Recombinant Human CEP290 Protein, GST-Tagged Wheat Germ GST
    Zebrafish CEP290-7640Z Recombinant Zebrafish CEP290 Mammalian Cell His

    cep290 involved in several pathways and played different roles in them. We selected most pathways cep290 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with cep290 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Anchoring of the basal body to the plasma membrane TCTN3; ACTR1A; DCTN2; CLASP1A; SSNA1; DYNC1H1; TUBB4B; ODF2B; CEP89; CLASP1
    Assembly of the primary cilium WDR34; TMEM216; CYS1; CEP63; TSGA14; DYNC1H1; IFT122; CETN2; TTC30A; DYNLL2A
    Cell Cycle MAU2; ENSA; NEK7; UIMC1; POT1; ANAPC13; SPO11; CDCA8; WEE1; CENPA
    Centrosome maturation CEP57; DYNC1I2; DCTN1; CP110; NUMA1; ACTR1A; CKAP5; ODF2B; CEP78; CEP76
    G2/M Transition CKAP5; LIN9; MAPRE1B; DYNC1H1; CEP72; TUBGCP4; LIN37; MAPRE1A; CEP70; DCTN1A
    Loss of Nlp from mitotic centrosomes CLASP1A; SDCCAG8; CEP76; ODF2B; TSGA14; CEP78; CEP164; CENPJ; CEP57; HAUS2
    Loss of proteins required for interphase microtubule organizationfrom the centrosome CEP57; CENPJ; MAPRE1B; CCP110; NDE1; CEP164; MAPRE1A; CEP290; CEP63; PCM1

    cep290 has several biochemical functions, for example, NOT microtubule minus-end binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cep290 itself. We selected most functions cep290 had, and list some proteins which have the same functions with cep290. You can find most of the proteins on our site.

    Function Related Protein
    NOT microtubule minus-end binding CEP290
    protein binding CEACAM1; LDOC1; RBM17; STAT6; NEK2; CASP9; C7orf53; METTL21C; KRTAP10-8; GRK6

    cep290 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cep290 here. Most of them are supplied by our site. Hope this information will be useful for your research of cep290.

    CCP110; CEP97; CEP76; ZNF423; CEP131; CCDC13

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