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Official Full Name charged multivesicular body protein 4A
Background CHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are;components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of;surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and;cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and;regulation of cell cycle progression (Tsang et al., 2006 (PubMed 16730941)).
Synonyms CHMP4A; charged multivesicular body protein 4A; C14orf123, chromatin modifying protein 4A , chromosome 14 open reading frame 123; HSPC134; VPS32A; C14orf123; Chromatin modifying protein 4a; SHAX2; SNF7 homolog associated with Alix-2; Snf7 homologue associated with Alix 2; vacuolar protein sorting-associated protein 32-1; SNF7; CHMP4; CHMP4B; SNF7-1; VPS32-1
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CHMP4A-11186H Recombinant Human CHMP4A, GST-tagged E.coli GST
    Human CHMP4A-1251H Recombinant Human CHMP4A Protein E.coli N/A
    Human CHMP4A-1252H Recombinant Human CHMP4A Protein, GST-Tagged Wheat Germ GST
    Human CHMP4A-1376H Recombinant Human Charged Multivesicular Body Protein 4A, His-tagged E.coli His
    Human CHMP4A-3233H Recombinant Human CHMP4A Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CHMP4A-351HCL Recombinant Human CHMP4A cell lysate N/A
    Human CHMP4A-6331H Recombinant Human CHMP4A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK

    chmp4a involved in several pathways and played different roles in them. We selected most pathways chmp4a participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with chmp4a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis ERBB3; KIF5A; ACAP3B; CSF1RA; GRK5; PLD2; STAM; CHMP4A; EPN3; EPS15L1

    chmp4a has several biochemical functions, for example, ATPase binding, identical protein binding, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by chmp4a itself. We selected most functions chmp4a had, and list some proteins which have the same functions with chmp4a. You can find most of the proteins on our site.

    Function Related Protein
    ATPase binding TOR1AIP2; PLN; SLN; ALDOB; ATP6V1E1; CHMP4A; ANK1; NR1H2; SDF2L1; ATP6V0A2
    identical protein binding OMG; MIEF1; EED; APOE; RNF4; ACADM; APAF1; DNM1L; IIGP1; ATG16L1
    lipid binding PLEKHA2; AP2M1B; FABP7; COQ9; APOE; SEC14L3; ACOT11A; FER; MARK2; EPN3
    protein binding DLC1; C16orf5; SGCA; RIPPLY1; ABCG1; AKT1S1; TEAD2; MAPRE2; PODXL2; VPS25
    protein homodimerization activity IRAK1; NRF1; CADM4; CAMK2D; ABAT; ASGR1; PON3; ABCB9; IRAK2; CALCOCO2

    chmp4a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with chmp4a here. Most of them are supplied by our site. Hope this information will be useful for your research of chmp4a.

    SYT17; USP54; PDCD6IP; ETS1; STAMBP; GAK; Ptpn23; TFG; Chmp4b

    Barlin, JN; Jelinic, P; et al. Validated gene targets associated with curatively treated advanced serous ovarian carcinoma. GYNECOLOGIC ONCOLOGY 128:512-517(2013).
    Shi, TP; Dong, YQ; et al. High-throughput screening identifies CHMP4A associated with hypoxia-inducible factor 1. LIFE SCIENCES 87:604-608(2010).

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