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Official Full Name cholinergic receptor, muscarinic 4
Background The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition.
Synonyms Cholinergic Receptor Muscarinic 4; Chrm 4; CHRM4; HM 4; HM4; M4; cholinergic receptor, muscarinic 4; M4R; Muscarinic M4 Receptor; OTTHUMP00000205575; muscarinic acetylcholine receptor M4
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CHRM4-1274H Recombinant Human CHRM4 Protein Wheat Germ N/A
    Mouse CHRM4-3427M Recombinant Mouse CHRM4 Protein Mammalian Cell His
    Rhesus Macaque CHRM4-861R Recombinant Rhesus monkey CHRM4 Protein, His-tagged Mammalian Cell His
    Chicken CHRM4-2855C Recombinant Chicken CHRM4 Mammalian Cell His
    Kit-0955 TR-FRET Glucocorticoid Receptor Coactivator Assay Kit N/A
    Kit-1172 CHRM4 Total GPCR Internalization Assay Kit N/A
    Kit-1173 CHRM4 CHO-K1 β-Arrestin GPCR Assay Kit N/A

    chrm4 involved in several pathways and played different roles in them. We selected most pathways chrm4 participated on our site, such as Amine ligand-binding receptors, Calcium Regulation in the Cardiac Cell, Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with chrm4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amine ligand-binding receptors HRH3; CHRM4; ADRA1B; DRD4; TAAR1; ADRA1D; CHRM2; CHRM3; ADRa1A; ADRA2B
    Calcium Regulation in the Cardiac Cell CASQ1; ADRB2; PKIG; GJA3; RGS11; RGS5; RGS17; GJC2; CX35.4; GJA4
    Cholinergic synapse GNB2; PIK3R3; CHRNA7; MAP2K1; PRKACB; PRKCB; FYN; CREB3; GNG8; CREB3L2
    Class A/1 (Rhodopsin-like receptors) CCBP2; OPN1SW; FPR-RS6; CCR6; OXGR1A.1; NPB; TAAR1; POMCB; OPN4; SST
    G alpha (i) signalling events OPN1MW; RLN3; S1PR5B; HEBP1; RGR; CCL19A.2; CNR1; RGS21; SST1.1; DRD2
    GPCR downstream signaling EDNRA; RAMP2; OXER1; SSTR4; FPR-RS3; APLN; KALRNB; TRPC3; GPR65; DRD2
    GPCR ligand binding GAL; CYSLTR1; AGT; NMS; CHRM4; CASR; CXCR6; CX3CR1; APLN; LPAR2A
    GPCRs, Class A Rhodopsin-like CNR1; SSTR4; FPR-RS3; OPN1MW2; GPR3; GPR4; GPR1; GPR39; NPFFR2; ACKR4

    chrm4 has several biochemical functions, for example, G-protein coupled acetylcholine receptor activity, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by chrm4 itself. We selected most functions chrm4 had, and list some proteins which have the same functions with chrm4. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled acetylcholine receptor activity CHRM5A; CHRM2; CHRM2A; CHRM5; CHRM4; CHRM3; CHRM1; CHRM5B
    guanyl-nucleotide exchange factor activity DENND4B; PREX1; FGD1; DOCK4; PTGIR; SH2D3C; RASGEF1BA; RINL; TBC1D10A; GAPVD1

    chrm4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with chrm4 here. Most of them are supplied by our site. Hope this information will be useful for your research of chrm4.

    Meixner, M; Atanasova, S; et al. Expression of Acetylcholine Receptors by Experimental Rat Renal Allografts. BIOMED RESEARCH INTERNATIONAL :-(2014).
    Conforti, P; Monteys, AM; et al. In vivo delivery of DN:REST improves transcriptional changes of REST-regulated genes in HD mice. GENE THERAPY 20:678-685(2013).

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