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Official Full Name cholinergic receptor, muscarinic 5
Background The muscarinic acetylcholine receptor M5 is a member of the GPCR family (subfamily, acetylcholine) which mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. The rimary transducing effect is PI turnover. The receptor has been reported to be expressed in blood, brain, and ovary. ESTs have been isolated from human testis and placenta libraries.
Synonyms CHRM5; cholinergic receptor, muscarinic 5; HM5; MGC41838; muscarinic acetylcholine receptor M5; OTTHUMP00000159731
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CHRM5-1275H Recombinant Human CHRM5 Protein Wheat Germ N/A
    Human CHRM5-1276H Recombinant Human CHRM5 Protein, GST-Tagged Wheat Germ GST
    Human CHRM5-7518HCL Recombinant Human CHRM5 293 Cell Lysate HEK293 N/A
    Mouse CHRM5-3428M Recombinant Mouse CHRM5 Protein Mammalian Cell His
    Rat CHRM5-1388R Recombinant Rat CHRM5 Protein Mammalian Cell His
    Rhesus Macaque CHRM5-862R Recombinant Rhesus monkey CHRM5 Protein, His-tagged Mammalian Cell His
    Chicken CHRM5-3194C Recombinant Chicken CHRM5 Mammalian Cell His
    Kit-0972 TR-FRET RAR alpha Coactivator Assay Kit, goat N/A
    Kit-1174 CHRM5 Activated GPCR Internalization Assay Kit N/A
    Kit-1175 CHRM5 CHO-K1 β-Arrestin GPCR Assay Kit N/A

    chrm5 involved in several pathways and played different roles in them. We selected most pathways chrm5 participated on our site, such as Amine ligand-binding receptors, Calcium Regulation in the Cardiac Cell, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with chrm5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amine ligand-binding receptors DRD1; CHRM3; ADRA1D; CHRM2; DRD5; CHRM5; HRH3; ADRA1B; ADRa1A; DRD4
    Calcium Regulation in the Cardiac Cell AKR1C1; GJB5; GJA4; RGS16; GJA3; GJB3; GJA5; RGS11; CCDC102A; CASQ1
    Calcium signaling pathway AKR1C1; ITPKB; PHKG1; TNNC2; CACNA1H; NOS3; PLCG2; STIM1A; F2R; CHRM5B
    Cholinergic synapse MAPK1; GNAI1; GNGT2; KCNQ5; CHRNA4; CREB3L3; GNGT1; GNG11; KCNJ6; PRKACG
    Class A/1 (Rhodopsin-like receptors) OPN1MW; CCR6; CXCR7B; CNR1; DRD5; INSL3; PMCH; GPR55A; UTS2D; GPR4
    G alpha (q) signalling events OPN4B; ANXA1A; EDN2; GPR68; OXTRL; ANXA1; ADRA1D; CYSLTR1; GPR4; TAC3
    GPCR downstream signaling MCF2L; TAS2R13; TRIO; ARHGEF25; GPR55A; TAS2R3; RGS18; ARHGEF17; DCLRE1B; DRD3
    GPCR ligand binding TAC1; NPFFR2; OXGR1; GPR4; CRHB; PNOCB; GPRC6A; CRHR1; CYSLTR1; HCAR1-2

    chrm5 has several biochemical functions, for example, G-protein coupled acetylcholine receptor activity, phosphatidylinositol phospholipase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by chrm5 itself. We selected most functions chrm5 had, and list some proteins which have the same functions with chrm5. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled acetylcholine receptor activity CHRM2; CHRM1; CHRM5B; CHRM5A; CHRM3; CHRM2A; CHRM5; CHRM4
    phosphatidylinositol phospholipase C activity PLCG2; PLCL2; PLCH2; CCKBR; PLD4; CHRM3; PLCE1; CCR1; PLCG1; EDNRA

    chrm5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with chrm5 here. Most of them are supplied by our site. Hope this information will be useful for your research of chrm5.

    Meixner, M; Atanasova, S; et al. Expression of Acetylcholine Receptors by Experimental Rat Renal Allografts. BIOMED RESEARCH INTERNATIONAL :-(2014).
    Lin, HJ; Wan, L; et al. Muscarinic Acetylcholine Receptor 3 Is Dominant in Myopia Progression. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 53:6519-6525(2012).

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