CHST3
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Official Full Name
carbohydrate (chondroitin 6) sulfotransferase 3
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Background
This gene encodes an enzyme which catalyzes the sulfation of chondroitin, a proteoglycan found in the extracellular matrix and most cells which is involved in cell migration and differentiation. Mutations in this gene are associated with spondylepiphyseal dysplasia and humerospinal dysostosis. -
Synonyms
CHST3; carbohydrate (chondroitin 6) sulfotransferase 3; carbohydrate sulfotransferase 3; C6ST; C6ST1; C6ST 1; C6ST-1; Chondroitin 6 O sulfotransferase 1; Chondroitin 6 sulfotransferase; Chondroitin 6-O-sulfotransferase 1; Chondroitin 6-sulfotransferase; CHST 3; CHST3_HUMAN; Galactose/N acetylglucosamine/N acetylglucosamine 6 O sulfotransferase 0; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0; GST 0; GST-0; GST0; OTTHUMP00000019779; HSD;
- Involved Pathway
- Protein Function
- Interacting Protein
CHST3 involved in several pathways and played different roles in them. We selected most pathways CHST3 participated on our site, such as Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHST3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | CHPF2;XYLT1;CHSY3;B3GALT6;CHST3B;B3GAT3;CSGALNACT2;CHPF;DSE |
CHST3 has several biochemical functions, for example, N-acetylglucosamine 6-O-sulfotransferase activity, chondroitin 6-sulfotransferase activity, proteoglycan sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHST3 itself. We selected most functions CHST3 had, and list some proteins which have the same functions with CHST3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| N-acetylglucosamine 6-O-sulfotransferase activity | CHST3B;CHST3;SULT2ST1;CHST3A;SULT1ST6;Chst5;SULT1ST5;HS6ST1A;HS3ST1L2 |
| chondroitin 6-sulfotransferase activity | CHST3;CHST3A;CHST7 |
| proteoglycan sulfotransferase activity | SULT1ST5;HS3ST3L;CHST2;SULT1ST1;HS3ST1L2;CHST3;HS6ST1A;SULT1ST6;SULT1D1 |
| sulfotransferase activity | SULT1ST5;SULT1ST4;DSEL;SULT1ST8;SULT2ST1;SULT3ST2;SULT1A3;CHST3;CHST2A |
CHST3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHST3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHST3.
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