CHST4
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Official Full Name
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 -
Overview
This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3phosphoadenosine 5phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein. -
Synonyms
CHST4;carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4;carbohydrate sulfotransferase 4;HEC GLCNAC 6 ST;LSST;Carbohydrate (N acetylglucosamine 6-O) sulfotransferase 4;Galactose/N acetylglucosamine/N acetylglucosamine 6 O sulfotransferase 3;GlcNAc6ST 2;GST 3;HEC GlcNAc6ST;High endothelial cells N acetylglucosamine 6 O sulfotransferase;L selectin ligand sulfotransferase;N acetylglucosamine 6 O sulfotransferase;GST-3;gn6st-2;glcNAc6ST-2;HEC-GlcNAc6ST;OTTHUMP00000174926;L-selectin ligand sulfotransferase;N-acetylglucosamine 6-O-sulfotransferase 2;high endothelial cells N-acetylglucosamine 6-O-sulfotransferase;galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3;galactose/N-acetylglucosamine/N-acetylgalactosamine 6-O-sulfotransferase 3;GST3;GlcNAc6ST2;HECGLCNAC6ST
Recombinant Proteins
- Human
- Mouse
- E.coli
- CHO
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CHST4-11230H | Recombinant Human CHST4, His-tagged | E.coli | Human | His | C-term-310a.a. | |
| CHST4-3227H | Recombinant Human CHST4 protein, His-tagged | E.coli | Human | His | 177-386 aa | |
| CHST4-561H |
Active Recombinant Human CHST4 Protein, His-tagged
|
CHO | Human | His | His29-His386 |
|
| CHST4-1344H | Recombinant Human CHST4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CHST4-3453M | Recombinant Mouse CHST4 Protein | Mammalian Cells | Mouse | His |
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| CHST4-1676M | Recombinant Mouse CHST4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| CHST4-1676M-B | Recombinant Mouse CHST4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CHST4-1835HF | Recombinant Full Length Human CHST4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 370 amino acids |
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Involved Pathway
CHST4 involved in several pathways and played different roles in them. We selected most pathways CHST4 participated on our site, such as Glycosaminoglycan biosynthesis - keratan sulfate,metapathway biotransformation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHST4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| metapathway biotransformation | SULT1C2,GAL3ST4,CYP20A1,SULT1B1,NAA40,KCNAB3,NAT8B,NAT9,CEACAM21,GAL3ST3 |
| Glycosaminoglycan biosynthesis - keratan sulfate | ST3GAL3B,FUT8A,CHST6,B4GALT2,FUT8,B4GALT1,Chst5,CHST2A,ST3GAL1,ST3GAL3 |
Protein Function
CHST4 has several biochemical functions, for example, N-acetylglucosamine 6-O-sulfotransferase activity,sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHST4 itself. We selected most functions CHST4 had, and list some proteins which have the same functions with CHST4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| N-acetylglucosamine 6-O-sulfotransferase activity | Sult3a1,CHST2A,CHST6,SULT1ST5,HS6ST1A,SULT2ST1,HS6ST3B,HS3ST3B1A,SULT1ST1,HS3ST3B1B |
| sulfotransferase activity | Sult2a2,SULT1ST5,HS3ST3L,HS3ST3B1B,SULT2A1,CHST3,SULT1ST7,SULT1A2,CHST3B,SULT3ST4 |
Interacting Protein
CHST4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHST4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHST4.
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