CLASP1

  • Official Full Name

    CLIP associating protein 1

  • Overview

    CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM;179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle;(Maiato et al., 2003 (PubMed 12837247)).

  • Synonyms

    CLASP1;CLIP associating protein 1;CLIP-associating protein 1;1700030C23Rik;B130045P17Rik;FLJ33821;FLJ41222;KIAA0622;MGC131895;mKIAA0622;5730583A19Rik;CLAP1_HUMAN;CLIP associating protein CLASP1;Cytoplasmic linker associated protein 1;Cytoplasmic linker-associated protein 1;DKFZp686D1968;DKFZp686H2039;hOrbit1;MAST1;Multiple asters 1;Multiple asters homolog 1;Protein Orbit homolog 1;CLASP1alpha;CLIP-associating protein CLASP1
Cat.# Product name Source (Host) Species Tag Protein Length Price
CLASP1-088H Recombinant Human CLASP1 protein, His-tagged E.coli Human His
CLASP1-1406H Recombinant Human CLASP1 Protein, GST-tagged Wheat Germ Human GST
CLASP1-188HCL Recombinant Human CLASP1 lysate HEK293 Human Non
CLASP1-112HKCL Human CLASP1 Knockdown Cell Lysate HeLa Human Non

    Involved Pathway

    CLASP1 involved in several pathways and played different roles in them. We selected most pathways CLASP1 participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLASP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Assembly of the primary cilium CSNK1E,CLASP1A,HDAC6,IFT80,IFT122,IFT27,CEP63,CEP290,KIF3C,NEDD1
    Axon guidance TRPC4,RAC1,CSF2,SRGAP1,EPHB3A,PTPRA,GNAI1,SEMA3B,EPHA8,FES
    Anchoring of the basal body to the plasma membrane CSNK1E,CEP135,CEP76,CEP97,PLK4,MAPRE1B,TUBB4A,NDE1,BBS13,FGFR1OP
    Cell cycle ANAPC11,E2F5,ORC3L,YWHABA,ESCO1,HDAC6,DBF4,E2F6,CEP63,ESPL1
    Cell Cycle, Mitotic MAU2,KIF2A,LMNB1,KIF18A,ENSAA,CSNK2B,DCTN1A,CDKN2B,BORA,CENPK
    Centrosome maturation TUBGCP5,CEP63,TUBB4B,CEP135,CKAP5,CDK11A,TUBGCP4,DYNC1H1,TUBGCP2,CEP78
    Developmental Biology RHOAE,TRPC3,CD24,LGI2B,SCN4A,GPC1A,LIN28A,LAMTOR2,SEMA3AA,TCF12
    G2/M Transition CEP164,NINL,CEP70,TUBGCP5,CEP152,LIN52,NUMA1,LIN9,TUBG1,CEP290

    Protein Function

    CLASP1 has several biochemical functions, for example, dystroglycan binding,kinetochore binding,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLASP1 itself. We selected most functions CLASP1 had, and list some proteins which have the same functions with CLASP1. You can find most of the proteins on our site.

    Function Related Protein
    kinetochore binding CENPH,CCDC99,CLASP1A,SPDL1
    dystroglycan binding AGRN,GYLTL1B,AGR3,MAP2,AGR2,DAG1,VCL,DMD
    microtubule binding KIF23,MACF1,DCX,RCC2,POLB,CETN2,ARHGEF2,BIRC5,PRC1,MTAP4
    microtubule plus-end binding KIF18A,KIF2C,MAPRE1,CLIP2,STIM1,CLASP1A,DST,CLIP1,APC
    protein binding SIGLEC8,GSTO1,PAX2,TXNL4A,EIF5A2,LRRC26,STK40,RGS8,MED24,PUM2

    Interacting Protein

    CLASP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLASP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLASP1.

    YWHAG;KIF1B;SPAG5;Clip2;Clip1;Cenpe;PHLDB2;HTT;pyrB;Soga1;Cenpe

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