CLASP1
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Official Full Name
CLIP associating protein 1 -
Overview
CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM;179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle;(Maiato et al., 2003 (PubMed 12837247)). -
Synonyms
CLASP1;CLIP associating protein 1;CLIP-associating protein 1;1700030C23Rik;B130045P17Rik;FLJ33821;FLJ41222;KIAA0622;MGC131895;mKIAA0622;5730583A19Rik;CLAP1_HUMAN;CLIP associating protein CLASP1;Cytoplasmic linker associated protein 1;Cytoplasmic linker-associated protein 1;DKFZp686D1968;DKFZp686H2039;hOrbit1;MAST1;Multiple asters 1;Multiple asters homolog 1;Protein Orbit homolog 1;CLASP1alpha;CLIP-associating protein CLASP1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CLASP1-088H | Recombinant Human CLASP1 protein, His-tagged | E.coli | Human | His | 1-238 aa | |
| CLASP1-1406H | Recombinant Human CLASP1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CLASP1-188HCL | Recombinant Human CLASP1 lysate | HEK293 | Human | Non |
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Involved Pathway
CLASP1 involved in several pathways and played different roles in them. We selected most pathways CLASP1 participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLASP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | Unc5b,EPHB4A,FGF20A,SLIT2,JAK1,TRIO,GPC1A,KDR,EVL,CAP2 |
| Cell Cycle, Mitotic | E2F3,GOLGA2,PIANP,H3F3D,NUP50,TSGA14,MLF1IP,TUBG1,CNEP1R1,CDK7 |
| Cell cycle | CENPN,TUBB4B,YWHABA,TUBGCP3,CDC14B,RB1,CCDC99,DHFR,PDS5B,APITD1 |
| Developmental Biology | SCN9A,KLB,CARM1,RND1L,ARPC4,SCN4A,GPC1A,MED9,EFNB3,NRG4 |
| G2/M Transition | TCTN2,SDCCAG8,DYNC1H1,CEP63,CCP110,DCTN3,TUBGCP5,CEP76,DCTN1A,CENPJ |
| Anchoring of the basal body to the plasma membrane | SDCCAG8,CEP63,ODF2,MARK4,ODF2B,DCTN1A,MAPRE1A,DCTN3,MAPRE1B,FBF1 |
| Assembly of the primary cilium | IFT22,IFT80,IFT43,NDE1,UNC119.1,NPHP3,CEP89,TCTEX1D2,KIF3C,TTBK2 |
| Centrosome maturation | CEP78,CEP63,CLASP1A,TUBG1,PLK4,CEP72,ODF2B,CEP70,PCM1,TUBGCP2 |
Protein Function
CLASP1 has several biochemical functions, for example, dystroglycan binding,kinetochore binding,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLASP1 itself. We selected most functions CLASP1 had, and list some proteins which have the same functions with CLASP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| microtubule binding | RCC2,APC,HDAC6,MAPRE2,CRYAB,MTAP1A,KIFC1,KIF27,CHD4A,KIF17 |
| microtubule plus-end binding | KIF18A,CLIP2,CLASP1A,KIF2C,MAPRE1,CLIP1,DST,APC,STIM1 |
| kinetochore binding | CENPH,CCDC99,SPDL1,CLASP1A |
| dystroglycan binding | AGR3,VCL,AGRN,GYLTL1B,DAG1,MAP2,AGR2,DMD |
| protein binding | BIK,TMSB4Y,PLDN,DNMT3L,PTPN22,CHEK2,FAM9B,NEURL1B,GFI1B,KLF15 |
Interacting Protein
CLASP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLASP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLASP1.
YWHAG;KIF1B;SPAG5;Clip2;Clip1;Cenpe;PHLDB2;HTT;pyrB;Soga1;Cenpe
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