CLASP1

  • Official Full Name

    CLIP associating protein 1

  • Overview

    CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM;179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle;(Maiato et al., 2003 (PubMed 12837247)).

  • Synonyms

    CLASP1;CLIP associating protein 1;CLIP-associating protein 1;1700030C23Rik;B130045P17Rik;FLJ33821;FLJ41222;KIAA0622;MGC131895;mKIAA0622;5730583A19Rik;CLAP1_HUMAN;CLIP associating protein CLASP1;Cytoplasmic linker associated protein 1;Cytoplasmic linker-associated protein 1;DKFZp686D1968;DKFZp686H2039;hOrbit1;MAST1;Multiple asters 1;Multiple asters homolog 1;Protein Orbit homolog 1;CLASP1alpha;CLIP-associating protein CLASP1
Cat.# Product name Source (Host) Species Tag Protein Length Price
CLASP1-088H Recombinant Human CLASP1 protein, His-tagged E.coli Human His
CLASP1-1406H Recombinant Human CLASP1 Protein, GST-tagged Wheat Germ Human GST
CLASP1-188HCL Recombinant Human CLASP1 lysate HEK293 Human Non
CLASP1-112HKCL Human CLASP1 Knockdown Cell Lysate HeLa Human Non

    Involved Pathway

    CLASP1 involved in several pathways and played different roles in them. We selected most pathways CLASP1 participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLASP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    G2/M Transition LIN9,CDK11A,LIN52,PCM1,CEP78,ODF2B,MAPRE1A,CEP57,SDCCAG8,SSNA1
    Cell cycle TFDP1A,GADD45AB,DCTN1,TMEM188,SUN1,CCND2,CDKN2D,CENPW,POT1,PDS5A
    Anchoring of the basal body to the plasma membrane CCDC123,DCTN3,CSNK1D,B9D2,CETN2,CEP63,CEP290,CEP152,CCDC41,NPHP4
    Developmental Biology EFNA3,GDF1,SEMA3AA,LAMTOR2,EFNA1B,FRS2A,DPYSL5B,FRS3,PAQR3B,GPC1A
    Centrosome maturation MAPRE1,TUBB4B,DYNC1I2,CENPJ,CEP70,CKAP5,SDCCAG8,TUBG1,NDE1,CLASP1A
    Axon guidance MAPK1,EGF,HFE2,SEMA3E,EPHA6,SRGAP1,CLTB,LRRC4,DPYSL4,DPYSL5
    Assembly of the primary cilium CCP110,TRAF3IP1,CEP164,TCTEX1D2,BBS12,NPHP1,C11orf60,TTC30A2,BBS4,EXOC8
    Cell Cycle, Mitotic WAPAL,MCM8,TSGA14,CTDNEP1A,DPF1,GORASP1,DBF4,TUBGCP2,TUBGCP5,CEP290

    Protein Function

    CLASP1 has several biochemical functions, for example, dystroglycan binding,kinetochore binding,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLASP1 itself. We selected most functions CLASP1 had, and list some proteins which have the same functions with CLASP1. You can find most of the proteins on our site.

    Function Related Protein
    dystroglycan binding AGR3,MAP2,AGRN,AGR2,DAG1,VCL,DMD,GYLTL1B
    microtubule plus-end binding STIM1,CLIP2,DST,MAPRE1,CLASP1A,APC,KIF2C,CLIP1,KIF18A
    protein binding CCDC167,SHMT1,CCDC67,KRTAP19-7,TAP1,ATP7A,USP1,TRAM2,CREB1,SPOPL
    microtubule binding KIF15,MAPT,RACGAP1,CNN3,KIF22,SYBU,NDEL1A,KATNAL2,GAS2L2,KIF21A
    kinetochore binding CCDC99,SPDL1,CENPH,CLASP1A

    Interacting Protein

    CLASP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLASP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLASP1.

    YWHAG;KIF1B;SPAG5;Clip2;Clip1;Cenpe;PHLDB2;HTT;pyrB;Soga1;Cenpe

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