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Official Full Name chloride channel, voltage-sensitive 3
Background This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms CLCN3; chloride channel, voltage-sensitive 3; chloride channel 3; H(+)/Cl(-) exchange transporter 3; ClC 3; CLC3; chloride channel protein 3; chloride transporter ClC-3; ClC-3; DKFZp564I0463
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E. coli
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CLCN3-0481H Recombinant Human CLCN3 protein, His-tagged E.coli His
    Human CLCN3-01H Recombinant Human CLCN3 Protein, His-tagged E. coli His
    Human CLCN3-1417H Recombinant Human CLCN3 Protein, GST-tagged Wheat Germ GST
    Mouse CLCN3-3514M Recombinant Mouse CLCN3 Protein Mammalian Cell His
    Rat CLCN3-1426R Recombinant Rat CLCN3 Protein Mammalian Cell His

    clcn3 involved in several pathways and played different roles in them. We selected most pathways clcn3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with clcn3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    clcn3 has several biochemical functions, for example, ATP binding, PDZ domain binding, antiporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by clcn3 itself. We selected most functions clcn3 had, and list some proteins which have the same functions with clcn3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding GUK1; VPS4B; ATP13A3; CAMK1; RIOK3; PIK3C2B; MAP4K5; P2RX5; PASK; CKMT2A
    PDZ domain binding ACOX1; PTENA; MAP2K2; GNG5; DLC; FZD2; NLGN1; GIPC1; TBC1D10A; FZD1
    antiporter activity SLC4A8; CLCN4-2; Slc4a2; SLC26A3.1; SLC7A14; TMEM241; SLC38A3; SLC7A13; SLC7A8; SLC9A3.2
    chloride channel activity TTYH2L; SLC26A3.2; CLIC5B; APOL1; CLCN7; CLCNKB; CLCA2; GABRG1; CLCA5; CLCC1
    ion channel activity AKR1C1; KCNA6A; TRPM5; CATSPER2; DDX1; GRIN1A; KCNC1A; TRPC2B; KCNQ2A; GABRA6A
    nucleotide binding HIPK2; ABCC5; RBM7; MYHZ2; GNAV1; ATP1A3B; MTHFSD; SFRS3B; EPHA4A; SRPK1A
    protein heterodimerization activity H2AFB3; HIST1H2AM; EXT1; SMC4; HER1; TAF11; LTC4S; TPD52L2; TENM2; KCNA3
    voltage-gated chloride channel activity ANO6; CLCN1A; CLCNKA; CLCN7; CLCN3; CLCN4-2; CLCN1; CLCNK; CLCNKB; CLCN4
    voltage-gated ion channel activity KCNV2; KCNB2; KCNJ1A.4; CLIC3; SCN4AA; SCN1LAB; CX35B; SCN8AA; KCNK4; KCNK7
    NOT volume-sensitive chloride channel activity CLCN3

    clcn3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with clcn3 here. Most of them are supplied by our site. Hope this information will be useful for your research of clcn3.


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