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Official Full Name claudin 22
Background This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3 UTR of the WWC2 gene (GeneID: 80014) on the opposite strand.
Synonyms CLDN22; claudin 22; claudin-22; CLDN21; CLD22_HUMAN; FLJ51450
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • C-Myc/DDK
    • His
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CLDN22-142H Recombinant Human CLDN22 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human CLDN22-3244H Recombinant Human CLDN22 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse CLDN22-3533M Recombinant Mouse CLDN22 Protein Mammalian Cell His
    Rhesus Macaque CLDN22-894R Recombinant Rhesus monkey CLDN22 Protein, His-tagged Mammalian Cell His

    cldn22 involved in several pathways and played different roles in them. We selected most pathways cldn22 participated on our site, such as Cell adhesion molecules (CAMs), Tight junction, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with cldn22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) MAG; CD28; NCAM1A; CDH15; HLA-DPA1; ICAM3; CLDN4; CD274; CD8B; NADL1.2
    Tight junction MAGI1B; F11R; PRKCG; MAGI3; JAM3; MYL2; CLDN10A; PRKCHA; ACTG1; PARD6GB
    Leukocyte transendothelial migration CLDN1; MYL12B; ARHGAP5; ACTB; PIK3R5; CYBB; Itgam&Itgb2; ACTG1; JAM2; CLDN3
    Hepatitis C KRAS; IRF1; IFNAR1; IFNA14; OAS2; PPP2CB; CLDN20; Ifna11; TRAF6; PPP2R2B

    cldn22 has several biochemical functions, for example, molecular_function, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cldn22 itself. We selected most functions cldn22 had, and list some proteins which have the same functions with cldn22. You can find most of the proteins on our site.

    Function Related Protein
    molecular_function THSD7B; LRIG2; FADS3; NOG3; SPON2A; DNAJB13; TPM3; TMEM2; JRKL; NRM
    structural molecule activity ROCK2; TUBA1B; EPB41L3B; COL4A3; KRT31; SYNC; MAP7D1B; CLDND; ADD1; CLDN15LA

    cldn22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cldn22 here. Most of them are supplied by our site. Hope this information will be useful for your research of cldn22.

    Tominaga, A; Konishi, Y; et al. Autonomous cure of damaged human intestinal epithelial cells by TLR2 and TLR4-dependent production of IL-22 in response to Spirulina polysaccharides. INTERNATIONAL IMMUNOPHARMACOLOGY 17:1009-1019(2013).
    Bauerschlag, D; Brautigam, K; et al. Systematic analysis and validation of differential gene expression in ovarian serous adenocarcinomas and normal ovary. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 139:347-355(2013).

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