CLEC4A

  • Official Full Name

    C-type lectin domain family 4, member A

  • Overview

    A member of the calcium-dependent (C-type) lectin receptor (CLR) family, DCIR (for dendritic cell (DC) immunoreceptor), is a type II membrane glycoprotein of 237 aa with a single carbohydrate recognition domain (CRD), closest in homology to those of the macrophage lectin and hepatic asialoglycoprotein receptors. The intracellular domain of DCIR contains a consensus immunoreceptor tyrosine-based inhibitory motif (ITIM). A mouse cDNA, encoding a homologous protein has been identified. Northern blot analysis shows that DCIR mRNA is predominantly transcribed in hematopoietic tissues. DCIR displays a typical lectin CRD and is expressed on DCs, monocytes, macrophages, B lymphocytes, and granulocytes, but not detected on NK and T cells. DCIR is strongly expressed by DCs derived from blood monocytes cultured with GM-CSF and IL-4. DCIR is preferentially expressed by monocyte-related rather than Langerhans cell related DCs obtained from CD34+ progenitor cells. Finally, DCIR expression is down-regulated by signals inducing DC maturation such as CD40 ligand, LPS, or TNF- . Thus, DCIR is differentially expressed on DCs depending on their origin and stage of maturation/activation. DCIR represents a novel surface molecule expressed by antigen-presenting cells, and of potential importance in regulation of DC function.
  • Synonyms

    DCIR; LLIR; DDB27; CLECSF6; HDCGC13P; C-type lectin domain family 4 member A; C-type lectin DDB27; lectin-like immunoreceptor; dendritic cell immunoreceptor; C-type lectin superfamily member 6; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6; OTTHUMP00000239071; OTTHUMP00000239070; OTTHUMP00000239052; CLEC4A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Rhesus monkey
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Wheat Germ
  • C
  • hFc
  • GST
  • His
  • His|SUMO|Myc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLEC4A-1467H Recombinant Human CLEC4A Protein, GST-tagged Wheat Germ GST
Human CLEC4A-3353H Recombinant Human CLEC4A protein(Gln70-Leu237), His-tagged HEK293 N-His Gln70-Leu237
Human CLEC4A-2282HCL Recombinant Human CLEC4A cell lysate Human Cell N/A
Human CLEC4A-2158HF Recombinant Full Length Human CLEC4A Protein, GST-tagged In Vitro Cell Free System GST 237 amino acids
Human CLEC4A-796H Recombinant Human CLEC4A Protein, His-tagged E.coli N-His Gln70-Leu237
Human CLEC4A-110H Recombinant Human CLEC4A Protein, His-tagged E.coli His
Human CLEC4A-1066H Recombinant Human CLEC4A protein(Gln70-Leu237), hFc-tagged HEK293 C-hFc Gln70-Leu237
Mouse CLEC4A-1342M Recombinant Mouse CLEC4A protein(Gln70-Leu238), His-tagged HEK293 N-His Gln70-Leu238
Mouse CLEC4A-2212M Recombinant Mouse CLEC4A Protein (70-238 aa), His-SUMO-Myc-tagged E.coli His/SUMO/Myc 70-238 aa
Rhesus monkey CLEC4A-1791R Recombinant Rhesus Monkey CLEC4A Protein HEK293 N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CLEC4A involved in several pathways and played different roles in them. We selected most pathways CLEC4A participated on our site, such as C-type lectin receptors (CLRs), Dectin-2 family, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLEC4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
C-type lectin receptors (CLRs)CLEC4D;ITPR2;UBE2V1;CASP8L1;MALT1;CREBBP;AHCYL1;TAB1;CLEC6A
Dectin-2 familyCLEC4D;CLEC6A;CLEC4A
Immune SystemTREM1;CASPBL;LILRA1;RNF6;TIRAP;RNF34;UFL1;BTLA;C1rb
Innate Immune SystemTAX1BP1;TAX1BP1B;PELI3;WASF3;ABI1B;NLRP4B;LAT2;CTSK;BTR30

CLEC4A has several biochemical functions, for example, carbohydrate binding, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLEC4A itself. We selected most functions CLEC4A had, and list some proteins which have the same functions with CLEC4A. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingSORD;ILLR1;KLRB1F;SIGLEC8;REG3A;KLRB1;CLC;GALNT14;GANAB
transmembrane signaling receptor activityTLR1;GIPR;OR4C12;KLRC2;IGSF6;ICAM1;SLC22A17;ANTXR1;EMR4

CLEC4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLEC4A here. Most of them are supplied by our site. Hope this information will be useful for your research of CLEC4A.

Research Area

Related articles

Ishibashi, M; Morita, N; et al. CLEC4M-positive and CD81-negative Huh7 cells are not susceptible to JFH-1 HCVcc infection but mediate transinfection. ARCHIVES OF VIROLOGY 159:2949-2955(2014).
Wang, MY; Wang, FP; et al. Mannan-Binding Lectin Inhibits Candida albicans-Induced Cellular Responses in PMA-Activated THP-1 Cells through Toll-Like Receptor 2 and Toll-Like Receptor 4. PLOS ONE 8:-(2013).
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