Recombinant Human CLEC4A Protein, His-tagged
Cat.No. : | CLEC4A-110H |
Product Overview : | Recombinant Human CLEC4A Protein with His tag was expressed in E. coli. |
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Description : | C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca2+-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8+ T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8+ T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | ~24 kDa |
AA Sequence : | MQKYSQLLEKKTTKELVHTTLECVK KNMPVEETAWSCCPKNWKSFSSNCY FISTESASWQDSEKDCARMEAHLLV INTQEEQDFIFQNLQEESAYFVGLS DPEGQRHWQWVDQTPYNESSTFWHP REPSDPNERCVVLNFRKSPKRWGWN DVNCLGPQRSVCEMMKIHL |
Purity : | Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
Notes : | For research use only, not for use in diagnostic procedure. |
Storage : | Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
Storage Buffer : | PBS, 4M Urea, pH7.4 |
Gene Name : | CLEC4A C-type lectin domain family 4, member A [ Homo sapiens (human) ] |
Official Symbol : | CLEC4A |
Synonyms : | CLEC4A; C-type lectin domain family 4, member A; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 6 , CLECSF6; C-type lectin domain family 4 member A; DCIR; DDB27; C-type lectin DDB27; lectin-like immunoreceptor; dendritic cell immunoreceptor; C-type lectin superfamily member 6; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6; LLIR; CLECSF6; HDCGC13P; |
Gene ID : | 50856 |
mRNA Refseq : | NM_016184 |
Protein Refseq : | NP_057268 |
MIM : | 605306 |
UniProt ID : | Q9UMR7 |
Products Types
◆ Recombinant Protein | ||
CLEC4A-1066H | Recombinant Human CLEC4A protein(Gln70-Leu237), hFc-tagged | +Inquiry |
CLEC4A-2212M | Recombinant Mouse CLEC4A Protein (70-238 aa), His-SUMO-Myc-tagged | +Inquiry |
CLEC4A-796H | Recombinant Human CLEC4A Protein, His-tagged | +Inquiry |
CLEC4A-1342M | Recombinant Mouse CLEC4A protein(Gln70-Leu238), His-tagged | +Inquiry |
CLEC4A-3353H | Recombinant Human CLEC4A protein(Gln70-Leu237), His-tagged | +Inquiry |
◆ Lysates | ||
CLEC4A-2282HCL | Recombinant Human CLEC4A cell lysate | +Inquiry |
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