Recombinant Human CLEC4A Protein, His-tagged

• Cat.No.: CLEC4A-110H
• Product Overview: Recombinant Human CLEC4A Protein with His tag was expressed in E. coli.

Specification

• Description: C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca2+-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8+ T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8+ T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: ~24 kDa
• AA Sequence: MQKYSQLLEKKTTKELVHTTLECVK KNMPVEETAWSCCPKNWKSFSSNCY FISTESASWQDSEKDCARMEAHLLV INTQEEQDFIFQNLQEESAYFVGLS DPEGQRHWQWVDQTPYNESSTFWHP REPSDPNERCVVLNFRKSPKRWGWN DVNCLGPQRSVCEMMKIHL
• Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
• Storage Buffer: PBS, 4M Urea, pH7.4

Gene Information

• Gene Name: CLEC4A C-type lectin domain family 4, member A [ Homo sapiens (human) ]
• Official Symbol: CLEC4A
• Synonyms: CLEC4A; C-type lectin domain family 4, member A; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 6 , CLECSF6; C-type lectin domain family 4 member A; DCIR; DDB27; C-type lectin DDB27; lectin-like immunoreceptor; dendritic cell immunoreceptor; C-type lectin superfamily member 6; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6; LLIR; CLECSF6; HDCGC13P
• Gene ID: 50856
• mRNA Refseq: NM_016184
• Protein Refseq: NP_057268
• MIM: 605306
• UniProt ID: Q9UMR7