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Official Full Name CDC-like kinase 4
Background The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined.
Synonyms CLK4; CDC-like kinase 4; dual specificity protein kinase CLK4; OTTMUSP00000005756; OTTMUSP00000005757; OTTMUSP00000041113; AI987988; C85119; CDC like kinase 4; DKFZp686A20267; Protein serine threonine kinase Clk4; RP23-9N7.1
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CLK4-1500H Recombinant Human CLK4 Protein, GST-tagged Insect Cell GST
    Human CLK4-1501H Recombinant Human CLK4 Protein, GST-tagged Wheat Germ GST
    Human CLK4-366HCL Recombinant Human CLK4 cell lysate N/A
    Mouse CLK4-3588M Recombinant Mouse CLK4 Protein Mammalian Cell His
    Rhesus Macaque CLK4-913R Recombinant Rhesus monkey CLK4 Protein, His-tagged Mammalian Cell His

    clk4 involved in several pathways and played different roles in them. We selected most pathways clk4 participated on our site, such as mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with clk4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    mRNA processing PRMT2; CLK2; SREK1; RNASET2B; RBM33; SNRPN; MCTS2; ZFP622; HNRNPA2B1; SF3B4

    clk4 has several biochemical functions, for example, ATP binding, protein binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by clk4 itself. We selected most functions clk4 had, and list some proteins which have the same functions with clk4. You can find most of the proteins on our site.

    Function Related Protein
    protein binding TAF12; NME2; OXR1; ZFP110; DOCK9; PRPF4; FCGR1A; MAMSTR; MLLT3; ARHGEF6
    protein serine/threonine kinase activity GM711; PAK2; SMOK3B; MAP3K10; SRPK1A; MOK; PRPF4B; NEK2; SQSTM1; MAPK8
    protein serine/threonine/tyrosine kinase activity RPS6KA2; ACVR2B; DYRK3; MAP2K2; PRKACA; AURKB; DYRK1B; DSTYK; DYRK4; TNK2
    protein tyrosine kinase activity BCR; MAP2K3; INSR; BTK; EK1; ERBB2; MET; PTK7A; IGF1RB; EPHA7

    clk4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with clk4 here. Most of them are supplied by our site. Hope this information will be useful for your research of clk4.

    KPNA1; KRTAP10-7; KRTAP10-8; KRTAP10-9; SRPK1; UBL5; RNF181; RGMA; AHCYL2

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