Recombinant Human CLK4 Protein, GST-tagged

• Cat.No.: CLK4-1501H
• Product Overview: Human CLK4 full-length ORF ( NP_065717.1, 1 a.a. - 481 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 78.54 kDa
• AA Sequence: MRHSKRTHCPDWDSRESWGHESYRG SHKRKRRSHSSTQENRHCKPHHQFK ESDCHYLEARSLNERDYRDRRYVDE YRNDYCEGYVPRHYHRDIESGYRIH CSKSSVRSRRSSPKRKRNRHCSSHQ SRSKSHRRKRSRSIEDDEEGHLICQ SGDVLRARYEIVDTLGEGAFGKVVE CIDHGMDGMHVAVKIVKNVGRYREA ARSEIQVLEHLNSTDPNSVFRCVQM LEWFDHHGHVCIVFELLGLSTYDFI KENSFLPFQIDHIRQMAYQICQSIN FLHHNKLTHTDLKPENILFVKSDYV VKYNSKMKRDERTLKNTDIKVVDFG SATYDDEHHSTLVSTRHYRAPEVIL ALGWSQPCDVWSIGCILIEYYLGFT VFQTHDSKEHLAMMERILGPIPQHM IQKTRKRKYFHHNQLDWDEHSSAGR YVRRRCKPLKEFMLCHDEEHEKLFD LVRRMLEYDPTQRITLDEALQHPFF DLLKKK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CLK4 CDC-like kinase 4 [ Homo sapiens ]
• Official Symbol: CLK4
• Synonyms: CLK4; CDC-like kinase 4; dual specificity protein kinase CLK4; protein serine threonine kinase Clk4; DKFZp686A20267
• Gene ID: 57396
• mRNA Refseq: NM_020666
• Protein Refseq: NP_065717
• MIM: 607969
• UniProt ID: Q9HAZ1