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Official Full Name CCR4-NOT transcription complex, subunit 4
Background The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms CNOT4; CCR4-NOT transcription complex, subunit 4; NOT4; CCR4-NOT transcription complex subunit 4; CLONE243; NOT4H; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; potential transcriptional repressor NOT4Hp; NOT4 (negative regulator of transcr
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CNOT4-1582H Recombinant Human CNOT4 Protein, GST-tagged Wheat Germ GST
    Human CNOT4-7400HCL Recombinant Human CNOT4 293 Cell Lysate HEK293 N/A
    Human CNOT4-7401HCL Recombinant Human CNOT4 293 Cell Lysate HEK293 N/A
    Mouse Cnot4-2221M Recombinant Mouse Cnot4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Chicken CNOT4-2039C Recombinant Chicken CNOT4 Mammalian Cell His

    cnot4 involved in several pathways and played different roles in them. We selected most pathways cnot4 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with cnot4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    cnot4 has several biochemical functions, for example, ligase activity, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cnot4 itself. We selected most functions cnot4 had, and list some proteins which have the same functions with cnot4. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity RFFL; RANBP2; KCNG4; UBR1; RNF126; DZIP3; TRIML1; COP1; ACSL1; RNF181
    nucleotide binding CPEB1A; TDRD9; MAP2K4B; RAB1BB; PUF60A; RDBP; UBE1Y1; EPHA4A; DHX33; TUBA1L2
    poly(A) RNA binding AKAP17A; TIAL1; PRR3; RTCA; EEF1A1; NOVA1; FAM32A; PPRC1; PRKDC; SUGP2
    protein binding C1orf105; ZFPM2; RAN; ADAMTS3; CORO1B; SKAP2; HAUS1; POP1; APPB; MPP2
    ubiquitin-protein transferase activity UBE2D4; UBE2R2; RNF4; ANAPC4; MARCH1; UBR3; FEM1B; RNF146; TRAF2; CDC34
    zinc ion binding NEURL1AA; RNF215; ADAM10; FBXO40; RORCB; PMPCB; ZDHHC20; CA15A; CPSF4; CPA1

    cnot4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cnot4 here. Most of them are supplied by our site. Hope this information will be useful for your research of cnot4.

    UBE2D3; UBE2N; UBE2D2; EP300; UBE2E3; UBE2W; UBE2D4; MYC

    Babbarwal, V; Fu, JH; et al. The Rpb4/7 Module of RNA Polymerase II Is Required for Carbon Catabolite Repressor Protein 4-Negative on TATA (Ccr4-Not) Complex to Promote Elongation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:33125-33130(2014).
    Venturini, G; Rose, AM; et al. CNOT3 Is a Modifier of PRPF31 Mutations in Retinitis Pigmentosa with Incomplete Penetrance. PLOS GENETICS 8:-(2012).

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