Recombinant Full Length Human COL25A1 Protein, GST-tagged

• Cat.No.: COL25A1-2096HF
• Product Overview: Human COL25A1 full-length ORF ( AAH36669.1, 1 a.a. - 496 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 77.6 kDa
• Protein Length: 496 amino acids
• AA Sequence: MLLKKHAGKGGGREPRSEDPTPAEQ HCARTMPPCAVLAALLSVVAVVSCL YLGVKTNDLQARIAALESAKGAPSI HLLPDTLDHLKTMVQEKVERLLAQK SYEHMAKIRIAREAPSECNCPAGPP GKRGKRGRRGESGPPGQPGPQGPPG PKGDKGEQGDQGPRGPLGPPGQKGS IGAPGIPGMNGQKGEPGLPGAVGQN GIPGPKGEPGEQGEKGDAGENGPKG DTGEKGDPGSSAAGIKGEPGESGRP GQKGEPGLPGLPGLPGIKGEPGFIG PQGEPGLPGLPGTKGERGEAGPPGR GERGEPGAPGPKGKQGESGTRGPKG SKGDRGEKGDSGAQGPRGPPGQKGD QGATEIIDYNGNLHEALQRITTLTV TGPPGPPGPQGLQGTKGEQGSPGIP GMDGEQGLKGSKGDMGDPGSQWNER RKRRFWNAGSTGSFYHRPTRPTRSP WPTWPHGTSWTSWTKGSIWLRRKAR IPGYRWSYGTPWPCRSQRRKR
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: COL25A1 collagen, type XXV, alpha 1 [ Homo sapiens ]
• Official Symbol: COL25A1
• Synonyms: COL25A1; collagen, type XXV, alpha 1; collagen alpha-1(XXV) chain; alzheimer disease amyloid-associated protein; collagenous Alzheimer amyloid plaque component; collagen-like Alzheimer amyloid plaque component; AMY; CLAC; CLACP; CLAC-P
• Gene ID: 84570
• mRNA Refseq: NM_001256074
• Protein Refseq: NP_001243003
• MIM: 610004
• UniProt ID: Q9BXS0