COX17 Protein


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Official Full Name COX17 cytochrome c oxidase assembly homolog
Background Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13.
Synonyms COX17; COX17 cytochrome c oxidase assembly homolog (S. cerevisiae); COX17 (yeast) homolog, cytochrome c oxidase assembly protein , COX17 homolog, cytochrome c oxidase assembly protein (S. cerevisiae) , COX17 homolog, cytochrome c oxidase assembly protei
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Yeast
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COX17-11488H Recombinant Human COX17, GST-tagged E.coli GST
    Human COX17-1738H Recombinant Human COX17 Protein, GST-tagged Wheat Germ GST
    Human COX17-448H Recombinant Human COX17 (S. cerevisiae) E.coli N/A
    Mouse COX17-3810M Recombinant Mouse COX17 Protein Mammalian Cell His
    Rhesus Macaque COX17-984R Recombinant Rhesus monkey COX17 Protein, His-tagged Mammalian Cell His
    Chicken COX17-5641C Recombinant Chicken COX17 Mammalian Cell His
    Zebrafish COX17-1366Z Recombinant Zebrafish COX17 Mammalian Cell His
    Yeast COX17-449 Recombinant S.cervisiae S.cervisiae COX17 E.coli N/A

    COX17 involved in several pathways and played different roles in them. We selected most pathways COX17 participated on our site, such as Electron Transport Chain, Metabolic pathways, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Electron Transport Chain UCP2; COX6B1; SLC25A27; COX5B; COX11; COX8A; ATPIF1; ATP5S; NDUFS7; NDUFC2-KCTD14
    Metabolic pathways CMPK2; CHSY3; GGT5A; GK2; QDPRB2; FUT6; RPE; B3GAT3; AKR1B10; PET112L
    Metabolism of proteins HYOU1; GRP; DDIT3; CTSG; NOP56; TGFBI; NAPAB; EXOC3; TRAPPC4; BCHE
    Mitochondrial protein import TIMM44; TIMM17B; TIMM21; GRPEL1; HSCB; SAMM50; SLC25A12; FXC1; MTX2; TOMM40
    Oxidative phosphorylation SDHDB; LHPP; NDUFB2; ATP6V0CB; COX15; COX8C; ATP6V0CA; NDUFS8B; COX7A2L; NDUFB5

    COX17 has several biochemical functions, for example, copper chaperone activity, copper ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COX17 itself. We selected most functions COX17 had, and list some proteins which have the same functions with COX17. You can find most of the proteins on our site.

    Function Related Protein
    copper chaperone activity COX17; ATX1; ATOX1
    copper ion binding GPC1; LOXL3B; TRP53; COMMD1; AOC3; MOXD1L; LOXL2B; HEPHL1A; SOD3A; APOA4
    protein binding GFM1; SUN2; F11R; TSG101; DHPS; ZFC3H1; TTYH2; THBS4; CREB3; UTP11L

    COX17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX17 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX17.

    KATNAL1; PPBP; TP53; HADHB; SUMO2; EEF1A1; UNC119; RBM48; RIF1; COPS6; C14orf1; P

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