COX4I2

  • Official Full Name

    cytochrome c oxidase subunit IV isoform 2 (lung)

  • Overview

    Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation.
  • Synonyms

    COX4I2; cytochrome c oxidase subunit IV isoform 2 (lung); COX4L2, cytochrome c oxidase subunit IV isoform 2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial; COX4 2; COX4B; COXIV 2; cytochrome c oxidase subunit IV like 2; dJ857M17.2; COX IV-2; cy;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human COX4I2-1744H Recombinant Human COX4I2 Protein, GST-tagged Wheat Germ GST
Human COX4I2-388HCL Recombinant Human COX4I2 cell lysate N/A
Human COX4I2-2004HF Recombinant Full Length Human COX4I2 Protein, GST-tagged In Vitro Cell Free System GST 171 amino acids
Rat COX4I2-1551R Recombinant Rat COX4I2 Protein Mammalian Cell His
Rat COX4I2-1208R Recombinant Rat COX4I2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat COX4I2-1208R-B Recombinant Rat COX4I2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque COX4I2-988R Recombinant Rhesus monkey COX4I2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque COX4I2-813R-B Recombinant Rhesus Macaque COX4I2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque COX4I2-813R Recombinant Rhesus Macaque COX4I2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish COX4I2-11059Z Recombinant Zebrafish COX4I2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

COX4I2 involved in several pathways and played different roles in them. We selected most pathways COX4I2 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX4I2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationNDUFB10;ATP5D;COX15;SDHC;SDHA;ATP6AP2;ATP4A;ctaG;ATP6V1C1B
Metabolic pathwaysATP5G3A;DGAT1;GAA;POLR2J2;ACO2;ATP6V1D;CYP2J5;ATP6V0E1;COX8C
Cardiac muscle contractionATP1A3A;RYR2;MYH7;COX7C;COX5AA;TPM1;COX5A;COX6A2;CACNA1C
Non-alcoholic fatty liver disease (NAFLD)NDUFA8;RELA;NDUFB1;NDUFA10;NDUFC1;RAC1;NDUFA5;DDIT3;RXRA
Alzheimers diseaseNDUFS5;NDUFS6;PSENEN;COX8A;TNFRSF1A;GNAQ;NAE1;NDUFA5;COX6A1
Parkinsons diseaseNDUFS3;VDAC1;COX8C;NDUFA5;NDUFS7;SDHA;COX7A2;NDUFB5;ATP5J
Huntingtons diseaseATP5E;TFAM;NDUFS5;NDUFAB1;NDUFB5;NDUFA5;DNAL1;GNAQ;CYCS

COX4I2 has several biochemical functions, for example, cytoskeletal adaptor activity, metal ion binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COX4I2 itself. We selected most functions COX4I2 had, and list some proteins which have the same functions with COX4I2. You can find most of the proteins on our site.

Function Related Protein
cytoskeletal adaptor activityNCK1;ABI2;BAIAP2L1B;BAIAP2L2B;COX4I2;BIN3;BAIAP2;GAS2L1;NCK2
metal ion bindingSP5;ILKAP;HPDA;WBSCR17;ZNF776;ZNF410;PFKL;DOM3Z;PAPD4
poly(A) RNA bindingADD1;DDX5;NOL11;SREK1;LSM4;USO1;EXOSC7;HIST2H4A;FCF1
protein bindingCFH;MALT1;HMBOX1;TCEB1;RAB6A;RPF1;NACA;TIMELESS;HDAC7A
protein domain specific bindingBASP1;TUBA1A;RAB6A;ARR3;CENPJ;KCNN2;YWHAE2;SHROOM2;XPA
structural constituent of cytoskeletonTUBD1;ANK1;CYLC2;KRT14;KRT20;TUBA8L;KRT6B;TUBA8;EPB41L4B
structural constituent of muscleMYL2;DMD;TTN;MYL9;PLEC;CSRP3;CAPN3;NEXN;NEBL

COX4I2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX4I2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX4I2.

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