COX4I2 Protein


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Official Full Name cytochrome c oxidase subunit IV isoform 2 (lung)
Background Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation.
Synonyms COX4I2; cytochrome c oxidase subunit IV isoform 2 (lung); COX4L2, cytochrome c oxidase subunit IV isoform 2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial; COX4 2; COX4B; COXIV 2; cytochrome c oxidase subunit IV like 2; dJ857M17.2; COX IV-2; cy
    • Species :
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COX4I2-1744H Recombinant Human COX4I2 Protein, GST-tagged Wheat Germ GST
    Human COX4I2-388HCL Recombinant Human COX4I2 cell lysate N/A
    Rat COX4I2-1551R Recombinant Rat COX4I2 Protein Mammalian Cell His
    Rhesus Macaque COX4I2-988R Recombinant Rhesus monkey COX4I2 Protein, His-tagged Mammalian Cell His
    Zebrafish COX4I2-11059Z Recombinant Zebrafish COX4I2 Mammalian Cell His

    COX4I2 involved in several pathways and played different roles in them. We selected most pathways COX4I2 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX4I2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oxidative phosphorylation ATP5G3B; ATP6V1D; COX7A1; ATP6V1G2; ATP5H; ATP5A1; NDUFS2; NDUFA11; COX15; ATP6AP1B
    Metabolic pathways EPHX2; SPS2; IMPDH1A; KCNG4; NANS; PFAS; MIBP2; Akr1b3; HSD17B10; MAT2AA
    Cardiac muscle contraction CACNG1A; CACNB3A; CACNA1D; ATP1A3B; ATP1A1; COX6C; CACNA1SB; MYL2; COX7A3; CACNG7
    Non-alcoholic fatty liver disease (NAFLD) PIK3CA; PRKAG1; COX7B; IL6; NDUFA11; COX7A2; CYCS; GSK3A; RELA; KCNA3
    Alzheimers disease APH1C; NDUFA12; NDUFC1; CDK5R1; NDUFV2; COX8A; UQCRB; APP; ATF6; ITPR2
    Parkinsons disease NDUFB11; ATP5A1; NDUFB4; SDHC; NDUFA3; NDUFB5; NDUFC2-KCTD14; UQCRC1; ATP5J; NDUFA12
    Huntingtons disease NDUFS8; NDUFB4; RCOR1; VDAC1; PLCB3; POLR2H; POLR2K; NDUFA2; NDUFAB1; NDUFA12

    COX4I2 has several biochemical functions, for example, cytoskeletal adaptor activity, metal ion binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COX4I2 itself. We selected most functions COX4I2 had, and list some proteins which have the same functions with COX4I2. You can find most of the proteins on our site.

    Function Related Protein
    cytoskeletal adaptor activity NCK1; BICD1; BIN3; GAS2L2; GAS2L1; BAIAP2L2; ABI2; BAIAP2; COX4I2; SDCBP
    metal ion binding ZIC6; UNC13C; CXXC1A; ING5A; RXRBB; TPP1; ZBTB44; RNASEH2A; ATP1A1A.3; GLI3
    poly(A) RNA binding TPR; HSP90AA1; SMG1; DDX39A; CSNK1E; DUS3L; POP1; WDR3; U2AF1; MTHFSD
    protein binding GAPDHS; ROCK2A; PPP1R2P9; SRPK2; PLEKHG6; OAS1A; CETN3; ETF1; SUV420H2; WDR4
    protein domain specific binding ARRB2; YWHAH; GABRR1; SHROOM2; Akap2; LIN7C; SNCA; ARFIP2B; ZFP521; STX18
    structural constituent of cytoskeleton TUBB2; TUBA1A; EPB41L4B; ACTL7A; SPTBN1; SORBS2; EPB41; ACTR3; SPRR2A1; GFAP
    structural constituent of muscle MYBPC1; TPM4; MYL1; MYH11; MYL3; MYOT; DAG1; CSRP3; ANKRD2; SMTN

    COX4I2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX4I2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX4I2.

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