| Official Full Name | cytochrome c oxidase subunit IV isoform 2 (lung) |
| Background | Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. |
| Synonyms | COX4I2; cytochrome c oxidase subunit IV isoform 2 (lung); COX4L2, cytochrome c oxidase subunit IV isoform 2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial; COX4 2; COX4B; COXIV 2; cytochrome c oxidase subunit IV like 2; dJ857M17.2; COX IV-2; cy |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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COX4I2 involved in several pathways and played different roles in them. We selected most pathways COX4I2 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX4I2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | ATP5G3B; ATP6V1D; COX7A1; ATP6V1G2; ATP5H; ATP5A1; NDUFS2; NDUFA11; COX15; ATP6AP1B |
| Metabolic pathways | EPHX2; SPS2; IMPDH1A; KCNG4; NANS; PFAS; MIBP2; Akr1b3; HSD17B10; MAT2AA |
| Cardiac muscle contraction | CACNG1A; CACNB3A; CACNA1D; ATP1A3B; ATP1A1; COX6C; CACNA1SB; MYL2; COX7A3; CACNG7 |
| Non-alcoholic fatty liver disease (NAFLD) | PIK3CA; PRKAG1; COX7B; IL6; NDUFA11; COX7A2; CYCS; GSK3A; RELA; KCNA3 |
| Alzheimers disease | APH1C; NDUFA12; NDUFC1; CDK5R1; NDUFV2; COX8A; UQCRB; APP; ATF6; ITPR2 |
| Parkinsons disease | NDUFB11; ATP5A1; NDUFB4; SDHC; NDUFA3; NDUFB5; NDUFC2-KCTD14; UQCRC1; ATP5J; NDUFA12 |
| Huntingtons disease | NDUFS8; NDUFB4; RCOR1; VDAC1; PLCB3; POLR2H; POLR2K; NDUFA2; NDUFAB1; NDUFA12 |
COX4I2 has several biochemical functions, for example, cytoskeletal adaptor activity, metal ion binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COX4I2 itself. We selected most functions COX4I2 had, and list some proteins which have the same functions with COX4I2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytoskeletal adaptor activity | NCK1; BICD1; BIN3; GAS2L2; GAS2L1; BAIAP2L2; ABI2; BAIAP2; COX4I2; SDCBP |
| metal ion binding | ZIC6; UNC13C; CXXC1A; ING5A; RXRBB; TPP1; ZBTB44; RNASEH2A; ATP1A1A.3; GLI3 |
| poly(A) RNA binding | TPR; HSP90AA1; SMG1; DDX39A; CSNK1E; DUS3L; POP1; WDR3; U2AF1; MTHFSD |
| protein binding | GAPDHS; ROCK2A; PPP1R2P9; SRPK2; PLEKHG6; OAS1A; CETN3; ETF1; SUV420H2; WDR4 |
| protein domain specific binding | ARRB2; YWHAH; GABRR1; SHROOM2; Akap2; LIN7C; SNCA; ARFIP2B; ZFP521; STX18 |
| structural constituent of cytoskeleton | TUBB2; TUBA1A; EPB41L4B; ACTL7A; SPTBN1; SORBS2; EPB41; ACTR3; SPRR2A1; GFAP |
| structural constituent of muscle | MYBPC1; TPM4; MYL1; MYH11; MYL3; MYOT; DAG1; CSRP3; ANKRD2; SMTN |
COX4I2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX4I2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX4I2.
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