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COX6A1

Official Full Name

cytochrome c oxidase subunit VIa polypeptide 1
Overview

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented.
Synonyms

COX6A1; cytochrome c oxidase subunit VIa polypeptide 1; COX6A; cytochrome c oxidase subunit 6A1, mitochondrial; mitochondrial; COX VIa L; COX VIa-L; COX6AL; CX6A1_HUMAN; Cytochrome c oxidase polypeptide VIa liver; Cytochrome c oxidase polypeptide VIa-liver; Cytochrome c oxidase subunit 6A1; Cytochrome c oxidase subunit 6A1 mitochondrial; Cytochrome C oxidase subunit VIa homolog; Cytochrome c oxidase subunit VIA liver; Cytochrome c oxidase subunit VIA-liver; MGC104500; MS412;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	COX6A1-27583TH	Recombinant Human COX6A1	Wheat Germ	Non	109 amino acids	Inquiry
Human	COX6A1-1753H	Recombinant Human COX6A1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	COX6A1-7331HCL	Recombinant Human COX6A1 293 Cell Lysate	HEK293	Non		Inquiry
Human	COX6A1-91HF	Recombinant Full Length Human COX6A1 Protein	In Vitro Cell Free System		109 amino acids	Inquiry
Human	COX6A1-5841H	Recombinant Human COX6A1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Human	COX6A1-2010HF	Recombinant Full Length Human COX6A1 Protein, GST-tagged	In Vitro Cell Free System	GST	109 amino acids	Inquiry
Mouse	COX6A1-3817M	Recombinant Mouse COX6A1 Protein	Mammalian Cell	His		Inquiry
Mouse	COX6A1-1915M	Recombinant Mouse COX6A1 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	COX6A1-1915M-B	Recombinant Mouse COX6A1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Cox6a1-927M	Recombinant Mouse Cox6a1 Protein, MYC/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Zebrafish	COX6A1-1433Z	Recombinant Zebrafish COX6A1	Mammalian Cell	His		Inquiry
Chicken	COX6A1-4902C	Recombinant Chicken COX6A1	Mammalian Cell	His		Inquiry
Chicken	COX6A1-4901C	Recombinant Chicken COX6A1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

COX6A1 involved in several pathways and played different roles in them. We selected most pathways COX6A1 participated on our site, such as Alzheimers disease, Cardiac muscle contraction, Electron Transport Chain, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX6A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Alzheimers disease	NDUFS1;SDHC;NDUFV1;PLCB1;LPL;SDHB;CYCS;LRP1;ATF6
Cardiac muscle contraction	MYL2;CACNB4A;ACTC1B;CACNG8;CACNA2D2;ATP1B2;TNNC1;COX4I2;TNNC1B
Electron Transport Chain	SURF1;UCP3;SCO1;COX8A;NDUFC2-KCTD14;ATPIF1;COX6A1;COX5B;UCP2
Gene Expression	TNRC6B;NR1D2A;SUPT4H1;ZNF544;MBD3;HNRNPL;NR0B2A;HNRNPH2;ZNF189
Generic Transcription Pathway	ZNF484;NR2F1;ZNF266;ZNF205;ZNF19;ZFP1;ZNF473;ZNF189;ZNF599
Huntingtons disease	CYCS;POLR2H;NDUFA4;HDAC2;BDNF;CREB3L1;UQCRC2;COX7A2;COX8A
Metabolic pathways	ALDH3B1;MTHFD1L;MGAT4A;LIPG;SMS;GALNT10;PLD1;ATP6V1E1;CTH
Metabolism	SLC5A4;COX4I1;GNG13A;NDUFAF6;CYP4F22;ACOT11A;MED20;CHAT;CDK19

COX6A1 has several biochemical functions, for example, cytochrome-c oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX6A1 itself. We selected most functions COX6A1 had, and list some proteins which have the same functions with COX6A1. You can find most of the proteins on our site.

Function	Related Protein
cytochrome-c oxidase activity	COX5B2;COX6A2;COX8C;COX6B1;COX7A2L;COX5B;CYB5A;COX7A2;COX7C

COX6A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX6A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX6A1.

GRB2; HTT; CLPP

Research Area

HUNTSMAN, MM; ISACKSON, PJ; et al. LAMINA-SPECIFIC EXPRESSION AND ACTIVITY-DEPENDENT REGULATION OF 7 GABA(A) RECEPTOR SUBUNIT MESSENGER-RNAS IN MONKEY VISUAL-CORTEX. JOURNAL OF NEUROSCIENCE 14:2236-2259(1994).