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Official Full Name corticotropin releasing hormone receptor 2
Background The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms CRHR2; corticotropin releasing hormone receptor 2; corticotropin-releasing factor receptor 2; CRF RB; CRF2; HM CRF; Corticotropin-releasing hormone receptor 2; CRF 2; CRF 2R; CRF R2; CRF-R-2; CRF-R2; CRF2R; CRFR 2; CRFR-2; CRFR2; CRFR2_HUMAN; CRH 2R; CRH R2; CRH-R-2; CRH-R2; CRH2R; CRHR 2; CRF2 receptor, beta isoform; CRF-RB; HM-CRF
    • Species :
    • Chicken
    • Human
    • Rat
    • Zebrafish
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CRHR2-1869H Recombinant Human CRHR2 Protein Wheat Germ N/A
    Human CRHR2-1870H Recombinant Human CRHR2 Protein, GST-tagged Wheat Germ GST
    Human CRHR2-399HCL Recombinant Human CRHR2 cell lysate N/A
    Rat CRHR2-1598R Recombinant Rat CRHR2 Protein Mammalian Cell His
    Chicken CRHR2-6024C Recombinant Chicken CRHR2 Mammalian Cell His
    Zebrafish CRHR2-6358Z Recombinant Zebrafish CRHR2 Mammalian Cell His
    Kit-1034 5’-Nucleotidase (CD73)Activity Assay Kit (Colorimetric) N/A
    Kit-1184 CRHR2 CHO-K1 β-Arrestin GPCR Assay Kit N/A
    Kit-1185 cAMP CRHR2 CHO-K1 GPCR Assay Kit N/A

    crhr2 involved in several pathways and played different roles in them. We selected most pathways crhr2 participated on our site, such as Class B/2 (Secretin family receptors), Corticotropin-releasing hormone, G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with crhr2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Class B/2 (Secretin family receptors) ADCYAP1B; CRHB; PTHLHA; GCGB; CALCA; RAMP1; SCT; SETD6; CD97; CRHR2
    Corticotropin-releasing hormone CRHR1; CRHR2; CYP11B1; CYP11A1; KRT1; ADRBK2; PARP1; JUNB; CASP12; JUND
    G alpha (s) signalling events ADORA2B; ADCYAP1R1; RLN3; DRD5; GPBAR1; RXFP2B; CALCA; RLN2; ADM; CRHB
    GPCR downstream signaling GPR132B; AGTR2; ADRA2B; PROKR1A; APLNR; OXGR1A.2; LPAR2B; EDN3; OXER1; CHRM3
    GPCR ligand binding RHOL; RLN3; KISS1; RLN2; CRHR1; DRD3; CXCL13; XK; GPRC6A; CCR1
    GPCRs, Class B Secretin-like CD97; ELTD1; CRHR1; ADCYAP1R1; CRHR2; EMR2; EMR1; LPHN1; CALCRL
    Neuroactive ligand-receptor interaction DRD2L; TAAR10C; GRIN1B; PRLHR2B; DRD1A; LEPA; GRM8; CHRND; HTR7; LPAR2
    Signal Transduction RGR; IQGAP3; HEYL; WIPF2; GPR37L1; ACVR1C; STAM2; ABI1B; RLN3A; OR7D2

    crhr2 has several biochemical functions, for example, corticotrophin-releasing factor receptor activity, corticotropin-releasing hormone receptor activity, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by crhr2 itself. We selected most functions crhr2 had, and list some proteins which have the same functions with crhr2. You can find most of the proteins on our site.

    Function Related Protein
    corticotrophin-releasing factor receptor activity CRHR1; CRHR2
    corticotropin-releasing hormone receptor activity CRHR2; CRHR1
    hormone activity ADCYAP1B; PRL2A1; VIP; PTHLHA; LHB; NMB; UTS2A; INS1; ADM; ADM2
    peptide hormone binding GHSR; MC4R; AVPR1A; GALR3; NPR1; RXFP2; PTH1RB; MC3R; NPR2; SLC40A1
    protein binding RAMP3; PAX8; RSAD2; MED7; STX7; METTL17; RPRD1A; FPR1; GOLGA1; ADM

    crhr2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with crhr2 here. Most of them are supplied by our site. Hope this information will be useful for your research of crhr2.

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