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CRLF1

Official Full Name

cytokine receptor-like factor 1
Overview

This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome.
Synonyms

CRLF1; cytokine receptor-like factor 1; CISS; CISS1; CLF; CLF 1; cold induced sweating syndrome; CISS 1; CLF1; CRLF 1; Cytokine like factor 1; Cytokine receptor like factor 1; NR 6; NR6; ZcytoR 5; ZcytoR5; cytokine-like factor 1; class I cytokine receptor; cytokine type 1 receptor CRLP-1; CLF-1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
In Vitro Cell Free System
Insect Cell
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

Fc
GST
His
His (Fc)
Avi
Myc
His|GST
His|T7
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CRLF1&CLCF1-1036H	Active Recombinant Human CRLF1&CLCF1	Mammalian cells	N/A		Inquiry
Human	CRLF1-319H	Recombinant Human CRLF1, GST-tagged	Wheat Germ	GST		Inquiry
Human	CRLF1-311H	Recombinant Human CRLF1, GST-tagged	Wheat Germ	GST		Inquiry
Human	CRLF1-2144H	Recombinant Human Cytokine Receptor-like Factor 1, Fc Chimera	Mammalian Cell	Fc		Inquiry
Human	CRLF1-1428H	Recombinant Human CRLF1 protein, His & GST-tagged	E.coli	His/GST	Pro138~Arg422 (Accession # O75462)	Inquiry
Human	CRLF1-404HCL	Recombinant Human CRLF1 cell lysate		N/A		Inquiry
Human	CRLF1-5878H	Recombinant Human CRLF1 protein, His&Myc-tagged	E.coli	His&Myc	38-422aa	Inquiry
Human	CRLF1-96HF	Recombinant Full Length Human CRLF1 Protein, GST-tagged	In Vitro Cell Free System	GST		Inquiry
Human	CRLF1-5895H	Recombinant Human CRLF1 protein, His&Myc-tagged	Insect Cell	His&Myc	38-422aa	Inquiry
Mouse	CRLF1-3916M	Recombinant Mouse CRLF1 Protein	Mammalian Cell	His		Inquiry
Mouse	Crlf1-1429M	Recombinant Mouse Crlf1 protein, His & T7-tagged	E.coli	His/T7	Arg110~Asp408 (Accession # Q9JM58)	Inquiry
Mouse	CRLF1-1985M-B	Recombinant Mouse CRLF1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	CRLF1-1985M	Recombinant Mouse CRLF1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CRLF1 Related Research Area

CRLF1 involved in several pathways and played different roles in them. We selected most pathways CRLF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CRLF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

CRLF1 has several biochemical functions, for example, contributes_to ciliary neurotrophic factor receptor binding, contributes_to cytokine activity, cytokine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRLF1 itself. We selected most functions CRLF1 had, and list some proteins which have the same functions with CRLF1. You can find most of the proteins on our site.

Function	Related Protein
contributes_to ciliary neurotrophic factor receptor binding	CLCF1;CRLF1
contributes_to cytokine activity	IL12B;CLCF1;CRLF1;IL12A
cytokine binding	Fzd4;ELANE;IL17F;CXCR4;NRP2;GBP1;PARK7;NOG;IL31RA
protein binding	LRRK1;PSG5;CDC42;LSM4;PIAS2;TLE1;PICK1;CCDC87;YAP1
protein heterodimerization activity	SEPHS1;BCL2L10;OSTB;IKBKG;VAPB;BMP6;UNC13A;TLR2;PVRL1
receptor activity	CSF2RA;MED24;CLEC4M;NLGN2B;TNFRSF11A;GFRA4A;MCC;CADM2;VMN1R41

CRLF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRLF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CRLF1.

IL-6 Family Receptors