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Official Full Name cryptochrome 1 (photolyase-like)
Background Cryptochromes (from the Greek κρυπτ? χρ?μα, hidden colour) are a class of blue light-sensitive flavoproteins found in plants and animals. Cryptochromes are involved in the circadian rhythms of plants and animals, and in the sensing of magnetic fields in a number of species. The name Cryptochrome was proposed as a pun combining the cryptic nature of the photoreceptor, and the cryptogamic organisms on which many blue light studies were carried out. The two genes Cry1 and Cry2 code for the two cryptochrome proteins CRY1 and CRY2. In insects and plants, CRY1 regulates the circadian clock in a light-dependent fashion, whereas in mammals, CRY1 and CRY2 act as light-independent inhibitors of CLOCK-BMAL1 components of the circadian clock. In plants, blue light photoreception can be used to cue developmental signals
Synonyms CRY1; cryptochrome 1 (photolyase-like); PHLL1; cryptochrome-1; photolyase-like cryptochrome 1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CRY1-11596H Recombinant Human CRY1, His-tagged E.coli His
    Human CRY1-1922H Recombinant Human CRY1 Protein, GST-tagged Wheat Germ GST
    Human CRY1-2082H Recombinant Human CRY1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CRY1-639H Recombinant Human CRY1 Protein, His/GST-tagged E.coli His/GST
    Human CRY1-7269H Recombinant Human CRY1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CRY1-7269HCL Recombinant Human CRY1 293 Cell Lysate HEK293 N/A
    Mouse Cry1-2323M Recombinant Mouse Cry1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse CRY1-3931M Recombinant Mouse CRY1 Protein Mammalian Cell His
    Rat CRY1-1608R Recombinant Rat CRY1 Protein Mammalian Cell His
    Rhesus Macaque CRY1-1036R Recombinant Rhesus monkey CRY1 Protein, His-tagged Mammalian Cell His
    Chicken CRY1-5818C Recombinant Chicken CRY1 Mammalian Cell His

    Cry1 involved in several pathways and played different roles in them. We selected most pathways Cry1 participated on our site, such as BMAL1:CLOCK,NPAS2 activates circadian gene expression, Circadian Clock, Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cry1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    BMAL1:CLOCK,NPAS2 activates circadian gene expression CREBBP; HELZ2; NAMPT; CARM1; NCOA2; CRY2; DBP; NRIP1; CRY1
    Circadian Clock CRY1; HELZ2; NRIP1; NAMPT; DBP; RAI1; CSNK1E; CARM1; CPT1A; CRY2
    Circadian rhythm NR1D1; SKP1; RORC; PRKAG3; PRKAA1; PRKAG2; FBXL3; PRKAB1; PRKAA2; CSNK1E
    Diurnally regulated genes with circadian orthologs GFRA1; KLF9; CBX3; CRY1; UCP3; CEBPB; PURA; G0S2; CRY2; EIF4G2

    Cry1 has several biochemical functions, for example, NOT DNA (6-4) photolyase activity, DNA binding, blue light photoreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cry1 itself. We selected most functions Cry1 had, and list some proteins which have the same functions with Cry1. You can find most of the proteins on our site.

    Function Related Protein
    NOT DNA (6-4) photolyase activity CRY1; CRY2
    DNA binding RPAP1; ZNF484; CCDC71L; AIFM1; CDT1; GPBP1L1; DNMT1; SETDB1; NR6A1; DMTF1
    blue light photoreceptor activity CRY2; CRY1
    core promoter binding E2F1; SFPQ; E2F3; ELK1; NPAS2; NKX2-1; FOXO3; IFI16; FOXP3; E2F8
    core promoter sequence-specific DNA binding REST; SP1; CRY1; PPARG; SIRT1; ZFP750; KLF10; GATA3; NRIP1; CREM
    NOT deoxyribodipyrimidine photo-lyase activity CRY1; CRY2
    double-stranded DNA binding RAD51B; HLF; MRE11A; MEN1; MTERF2; ERCC5; XRCC6; SMAD2; DDX11; XRCC2
    histone deacetylase binding BRMS1L; CDC20; HDAC5; SP2; MAGEA2B; MAGEA1; SOD3; MAGEA2; CRY1; HIF1A
    nuclear hormone receptor binding TACC2; NCOR1; NCOA3; MED1; SMARCD3; NCOA2; CRX; HIF1A; MYOD1; NCOA1
    nucleotide binding ABCG5; RAB25B; CAMK2D2; DNM1A; DCLK3; HNRNPA1L2; PABPC4; VMHCL; ACTG2; ATP13A
    phosphatase binding DZIP3; DYSFIP1; ELL; WNK1; PPP1R18; TPRN; SLC9A3R1; DLG1L; PPP1R36; CHCHD3
    protein binding GAGE8; ASTE1; RARG; TBKBP1; PATL1; CBLL1; LYRM2; COPS5; AK3; CTNNB1
    protein kinase binding HCLS1; SHC4; CCND2; SOCS1; TBL2; PGAM1; LAX1; GSK3B; GDF3; SKAP1
    transcription factor activity, transcription factor binding LDB2A; CRY1; PER1; MTA2; TRP63; CRY2; HIF1A; LDB2B; NEUROG1; LDB1A
    transcription factor binding H2-AB1; NR0B1; YWHAZ; BCL2; PIAS2; ID1; HEY1; TFDP1A; HEYL; NFATC3
    ubiquitin binding TRP53INP2; UCHL3; KIF18A; BCL10; KCNS1; PARK2; UBE2N; IWS1; MARK4; VPS36

    Cry1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cry1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cry1.

    PLSCR1; CSNK1E; Cry1; Csnk1e; Timeless; GRN; SNRPD3; TRAF2; CBLB; LTBP4; MDFI; KRTAP4-12; Psmb5; SYNCRIP; BAG6; JAK3; Sesn2; Esrrb

    Sha, S; Yin, Y; et al. A New Method for Immobilizing Antibody Probes in Immunochips Based on DNA Hybridization. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 41:199-204(2013).
    Watari, R; Yamaguchi, C; et al. Light-dependent Structural Change of Chicken Retinal Cryptochrome4. JOURNAL OF BIOLOGICAL CHEMISTRY 287:42634-42641(2012).

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