CSF2RB
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Official Full Name
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
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Overview
The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). -
Synonyms
CSF2RB; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); IL3RB; cytokine receptor common subunit beta; CD131; IL5RB; GM-CSF/IL-3/IL-5 receptor common beta-chain; GM-CSF/IL-3/IL-5 receptor common beta subunit; colony-stimu;
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- Involved Pathway
- Protein Function
- Interacting Protein
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CSF2RB involved in several pathways and played different roles in them. We selected most pathways CSF2RB participated on our site, such as ARMS-mediated activation, Apoptosis, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSF2RB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ARMS-mediated activation | PSMD9;DUSP2;DUSP9;FGF20A;CRK;FRS2;DUSP4;NETO2;CSF2RB |
| Apoptosis | NFKBIA;ATM;PPP3CA;CTNNB2;AKT2;CASP6;BOK;TNFRSF10B;IL1A |
| Axon guidance | SPNA2;PAK7;PAK3;RGMA;CREB1B;AP2A1;EFNA1;UNC5A;SLIT2 |
| Cytokine Signaling in Immune system | DUSP5;PEA15A;NRG2A;KLB;CISH;TRIM62;FRS2B;MAP3K8;PELI3 |
| Cytokine-cytokine receptor interaction | IL7R;KITLG;TNFRSF6B;IFNA14;PPBP;IFNL3;CCR9A;Ccl27a;IL1R2 |
| DAP12 interactions | LCP2A;CSF2RA;RASGRP4;DUSP1;MOV10;SPTBN1;KIR3DS1;SIGLEC15;HBEGF |
| DAP12 signaling | SPTA1;SPTBN2;CSF2RB;FRS2B;HBEGF;LAMTOR2;PAQR3A;PRKAR1AA;RASGRP4 |
| Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) | CSF2RA;CSF2RB;SFTPC;SFTPB |
CSF2RB has several biochemical functions, for example, contributes_to interleukin-3 receptor activity, contributes_to interleukin-5 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CSF2RB itself. We selected most functions CSF2RB had, and list some proteins which have the same functions with CSF2RB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to interleukin-3 receptor activity | |
| contributes_to interleukin-5 receptor activity | |
| protein binding | COL4A3;CALM1;ERH;LHX9;IL33;MED4;NDUFB10;PLN;MYO1E |
| receptor activity | CD46;TNFRSF25;F2RL1.2;CRLF1;ITGAX;CMKLR1;GUCY1B3;KLRG1;PAQR3B |
CSF2RB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSF2RB here. Most of them are supplied by our site. Hope this information will be useful for your research of CSF2RB.
JAK2; ITGB1; SHC1; PTPN11; CSF2; IL5; PTPN6
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