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Official Full Name C-terminal binding protein 2
Background This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3 untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.
Synonyms CTBP2; C-terminal binding protein 2; C-terminal-binding protein 2; ribeye; C terminal binding protein 2; CTBP2_HUMAN; OTTHUMP00000020699; OTTHUMP00000020700; OTTHUMP00000020701; OTTHUMP00000235908; OTTHUMP00000235909; OTTHUMP00000235910
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CTBP2-1451H Recombinant Human CTBP2 protein, His & T7-tagged E.coli His/T7
    Human CTBP2-2054H Recombinant Human CTBP2 Protein, GST-tagged Wheat Germ GST
    Human CTBP2-28021TH Recombinant Human CTBP2 Wheat Germ N/A
    Human CTBP2-3361H Recombinant Human CTBP2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CTBP2-417HCL Recombinant Human CTBP2 cell lysate N/A
    Human CTBP2-4647H Recombinant Human CTBP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CTBP2-6071H Recombinant Human CTBP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Ctbp2-2352M Recombinant Mouse Ctbp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse CTBP2-4010M Recombinant Mouse CTBP2 Protein Mammalian Cell His
    Rat CTBP2-1649R Recombinant Rat CTBP2 Protein Mammalian Cell His

    CTBP2 involved in several pathways and played different roles in them. We selected most pathways CTBP2 participated on our site, such as Chronic myeloid leukemia, Degradation of beta-catenin by the destruction complex, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chronic myeloid leukemia PTPN11; ABL1; HDAC2; TP53; NRAS; PIK3R3; RUNX1; SMAD4; STAT5A; MAPK3
    Degradation of beta-catenin by the destruction complex TLE2; FAM123B; TLE1; TLE4; AES; TLE3; TLE3B; CTBP2; CTBP1
    Diseases of signal transduction FGFR1OP; RBP4; KREMEN2; OS9; FGFR1OP2; RBP1; OPN1MW; TRAT1; STRA6; CCNC
    Neural Crest Differentiation DMBX1; TCF4; OLIG3; TFAP2A; DCT; ASCL1; SOX5; CDH7; SOX10; LHX1
    Notch Signaling Pathway LNX1; JAG2B; NCSTN; ADAM17A; KAT2A; NOTCH4; HER12; RBPJ; DTX3; PTCRA
    Pathways in cancer CTBP2; CASP8; LPAR2; GNG3; PIK3R1; NKX3-1; DAPK3; EPAS1; PIAS2; PRKACA

    CTBP2 has several biochemical functions, for example, NADH binding, chromatin binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by CTBP2 itself. We selected most functions CTBP2 had, and list some proteins which have the same functions with CTBP2. You can find most of the proteins on our site.

    Function Related Protein
    NADH binding CTBP2; CTBP2A; QDPR; CTBP1
    chromatin binding ADNP; ZGLP1; POU1F1; NFKB1; SHMT2; KDM6B; C10orf119; GATA5; CCDC111; PKN1
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GRHPRA; LDHBA; CTBP2A; MDH1AA; CTBP2; LDHBB; HMGCRA; UEVLD; TESCA; GPD1B
    protein binding RPL11; CDC25A; RAB27A; IL36RN; NUAK2; COLGALT2; NRP1; MAB21L1; KDM6B; SOX13
    protein homodimerization activity CADM4; NACC2; CUBN; MAP3K5; OXA1L; RAB11FIP4A; TMEM192; MAPK4; MBL1; UGT1A3
    retinoic acid receptor binding PRAME; CTBP2; MED1; LRIF1; MED25; RXRA; PRAMEF10; CNOT1; ASXL1; HMGA1-RS1
    transcription coactivator activity MAML2; ING4; NFE2; COPS5; DDX5; MTDH; RXRB; YAF2; TFDP1B; NFYC
    transcription corepressor activity ZFPM1; CTBP2A; RBFOX2; AES; TBL1X; SSX4; ATN1; PPP1R13L; TFCP2L1; CSDA

    CTBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTBP2.


    Neumann, S; Haverkamp, S; et al. Characterization of small-field bistratified amacrine cells in macaque retina labeled by antibodies against synaptotagmin-2. JOURNAL OF COMPARATIVE NEUROLOGY 521:709-724(2013).
    Muller, B; Butz, E; et al. The Rod Pathway of the Microbat Retina Has Bistratified Rod Bipolar Cells and Tristratified AII Amacrine Cells. JOURNAL OF NEUROSCIENCE 33:1014-1023(2013).

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