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Official Full Name cytochrome P450, family 1, subfamily B, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]
Synonyms CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1; CP1B; GLC3A; CYPIB1; P4501B1; cytochrome P450 1B1; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile);
    • Species :
    • Dog
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Rhesus monkey
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP1B1-01H Recombinant Human CYP1B1 Protein E.coli
    Human CYP1B1-28190TH Recombinant Human CYP1B1 protein, GST-tagged Wheat Germ GST
    Human CYP1B1-552H Recombinant Human CYP1B1 Insect Cell N/A
    Human CYP1B1-595H Recombinant Human CYP1B1 protein, His-tagged E.coli His
    Human CYP1B1-70H Recombinant Human CYP1B1 Protein E. coli
    Human CYP1B1-7125HCL Recombinant Human CYP1B1 293 Cell Lysate HEK293 N/A
    Mouse Cyp1b1-123M Recombinant Mouse Cyp1b1 Protein E. coli
    Mouse CYP1B1-4150M Recombinant Mouse CYP1B1 Protein Mammalian Cell His
    Rat Cyp1b1-140R Recombinant Rat Cyp1b1 Protein E. coli
    Rat CYP1B1-1717R Recombinant Rat CYP1B1 Protein Mammalian Cell His
    Rat CYP1B1-1939R Recombinant Rat CYP1B1 Protein (1-543 aa), His-tagged E.coli His
    Rhesus Macaque CYP1B1-1137R Recombinant Rhesus monkey CYP1B1 Protein, His-tagged Mammalian Cell His
    Rhesus monkey CYP1B1-130R Recombinant Rhesus monkey CYP1B1 Protein E. coli
    Dog CYP1B1-120D Recombinant Dog CYP1B1 Protein E. coli
    Zebrafish CYP1B1-4259Z Recombinant Zebrafish CYP1B1 Mammalian Cell His
    Zebrafish CYP1B1-7383Z Recombinant Zebrafish CYP1B1 Mammalian Cell His

    CYP1B1 involved in several pathways and played different roles in them. We selected most pathways CYP1B1 participated on our site, such as AhR pathway, Arachidonic acid metabolism, Benzo(a)pyrene metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AhR pathway FLG; CYP1A2; NQO1; EGFR; CDKN1A; CYP1B1; JUN; AHRR; CDC37; AHR
    Arachidonic acid metabolism CYP2C8; PTGES; PLA2G4C; PTGES3A; PLA2G10; CYP1B1; PTGDSA; CYP2P8; CYP2C45; CYP2B6
    Benzo(a)pyrene metabolism AKR1A1; CYP1A1; CYP3A4; AKR1C4; CYP1B1; AKR1C2; FAM84B
    Biological oxidations ACY3; CYP4T8; CYP2B6; CYP51A1; GLYAT; TPMT.2; CYP8B2; ADH5; SULT1C2; CYP2AD6
    Chemical carcinogenesis MGST1; CYP2C70; CYP2A13; ALDH3B2; CYP2C54; GSTA1; ADH2-1; ADH5; EPHX1; AHA-1
    Cytochrome P450 - arranged by substrate type CYP2AD2; CYP2U1; CYP3A5; CYP2K17; CYP2K8; CYP2N13; CYP3A4; FDX1; CYP2K22; CYP3A7-CYP3AP1
    Endogenous sterols FDX1; FDXR; CYP21A2; CYP27A1; CYP17A1; CYP51A1; CYP11B1; CYP46A1; FDX1L; CYP7A1
    Estrogen metabolism CYP1B1; ARSD; NQO1; CYP1A1; COMT; ARSE

    CYP1B1 has several biochemical functions, for example, aromatase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP1B1 itself. We selected most functions CYP1B1 had, and list some proteins which have the same functions with CYP1B1. You can find most of the proteins on our site.

    Function Related Protein
    aromatase activity CYP2C50; CYP1A; CYP2A7; CYP3A25; CYP3A5; CYP2C38; CYP2F1; CYP1B1; CYP2C55; CYP4A12A
    heme binding CYB5D2; NOX4; CYP2A13; CYP2K16; CYP1A4; MPO; CYP11B2; CYP4A12A; CYGB2; Adgb
    iron ion binding CYP2R1; TPH1A; CYP2K16; CYP2AA3; CYP4A10; FDX1; CYP2C9; CYP2AA9; CYP2AA1; CYP2AA7
    monooxygenase activity TH2; CYP26C1; CYP2AA12; CYP2C55; CH25HL2; CYP2AA2; CYP8B2; CYP2K17; CYP4A12A; CYP20A1
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2X10.2; CYP2AA7; CYP2AA4; CYP2A13; CYP19A1; CYP2X7; CYP2C39; CYP2D6; CYP2D9; CYP2K18
    oxygen binding CYP1A4; CYP2AA4; CYP2P6; NGB; CYP2F1; CBS; CYP2A12; CYP2A4; HBG1; CYP2AA9

    CYP1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP1B1.

    SAE1; fieF

    Chourasia, TK; Pang, YF; et al. The Catecholestrogen, 2-Hydroxyestradiol-17beta, Acts as a G Protein-Coupled Estrogen Receptor 1 (GPER/GPR30) Antagonist to Promote the Resumption of Meiosis in Zebrafish Oocytes. BIOLOGY OF REPRODUCTION 92:-(2015).
    Liu, Y; She, WM; et al. 3, 3 '-diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance. INTERNATIONAL IMMUNOPHARMACOLOGY 23:489-498(2014).

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