CYP24A1 Protein


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Official Full Name cytochrome P450, family 24, subfamily A, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms CYP24A1; cytochrome P450, family 24, subfamily A, polypeptide 1; CYP24, cytochrome P450, subfamily XXIV (vitamin D 24 hydroxylase); 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; CP24; P450 CC24; mitochondrial; 1 25 @dihydroxyvitamin D3 24 hydroxylase; 1 25 dihydroxyvitamin D(3) 24 hydroxylase; 1; 24 ohase; 24-OHase; 25-dihydroxyvitamin D(3) 24-hydroxylase; CP 24; CP24A_HUMAN; CYP 24; CYP24; Cytochrome P450 24A1; Cytochrome P450 24A1 mitochondrial; Cytochrome P450 family 24; Cytochrome P450 family 24 subfamily A polypeptide 1; Cytochrome P450 subfamily XXIV; Cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase); Cytochrome P450-CC24; EC 1.14.13.n4; Exo mitochondrial protein; MGC126273; MGC126274; Vitamin D 24 hydroxylase; Vitamin D(3) 24 hydroxylase; Vitamin D(3) 24-hydroxylase; OTTHUMP00000031314; OTTHUMP00000165939; OTTHUMP00000165940; vitamin D 24-hydroxylase; exo-mitochondrial protein; 1,25-@dihyd; HCAI; P450-CC24
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP24A1-11768H Recombinant Human CYP24A1, His-tagged E.coli His
    Human CYP24A1-251H Recombinant Human CYP24A1, GST-tagged Wheat Germ GST
    Mouse Cyp24a1-8075M Recombinant Mouse Cyp24a1 protein, His & T7-tagged E.coli His/T7
    Rat CYP24A1-1719R Recombinant Rat CYP24A1 Protein Mammalian Cell His
    Chicken CYP24A1-6538C Recombinant Chicken CYP24A1 Mammalian Cell His
    Zebrafish CYP24A1-5569Z Recombinant Zebrafish CYP24A1 Mammalian Cell His
    Human CYP24A1-7122HCL Recombinant Human CYP24A1 293 Cell Lysate HEK293 N/A

    CYP24A1 involved in several pathways and played different roles in them. We selected most pathways CYP24A1 participated on our site, such as Biological oxidations, Cytochrome P450 - arranged by substrate type, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP24A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations CYP2U1; ABHD14B; CYP4T8; ACY3.2; CYP2K6; CYP2J2; CYP4A11; ADH6; CYP46A1; CYP2E1
    Cytochrome P450 - arranged by substrate type CYP2W1; CYP4F22; CYP2N13; CYP8B2; CYP2A7; CYP2A6; CYP24A1; CYP3C4; CYP3C1; CYP1A1
    Metabolic pathways LIPT1; HMBSB; ACAT2; SUCLG2; MTMR1A; MOCS1; NDUFA4L; ybaS; ATP6V1G2; GMPPB
    Metabolism SLC25A12; MED20; TPMT.2; TCN1; AK7; ACOT9.1; SLC25A21; ACOT8; ABHD14B; SLC25A11
    Metabolism of lipids and lipoproteins GPAT2; ARV1; SREBF2; AWAT2; AKR1C21; ARSH; CEPT1; MED19; CPTP; TIAM2
    Metabolism of steroid hormones and vitamin D AKR1B15; CYP2R1; HSD17B11; GC; PPP1R2; CYP24A1; CYP27B1; STARD5
    MicroRNAs in cancer KIF23; SLC7A1; VEGFA; TNN; ERBB2; ZFPM2; PIM1; MMP16; RAF1; MDM4
    Nuclear receptors in lipid metabolism and toxicity RARGA; NR1I3; NR1I2; CYP24A1; VDRB; RARG; RARGB; CYP26A1; CYP27B1; ABCC2

    CYP24A1 has several biochemical functions, for example, 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity, 25-hydroxycholecalciferol-24-hydroxylase activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP24A1 itself. We selected most functions CYP24A1 had, and list some proteins which have the same functions with CYP24A1. You can find most of the proteins on our site.

    Function Related Protein
    1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity CYP24A1
    25-hydroxycholecalciferol-24-hydroxylase activity CYP24A1
    heme binding CYP7A1A; CYP27B1; HBB; CYP20A1; CYP2AA6; CYP2C38; CYP2K18; HBB-Y; TPO; CYP2P10
    iron ion binding CYP2P10; CYP2K22; CYP1D1; CYP19A1; HBQ1; CYP2B19; CYP24A1; HBA1; PTGIS; ALOX12B
    oxidoreductase activity CYP1A1; EGLN1B; HSDL1; CYP2AD2; CYP21A1; CYP2AD6; GFOD1; G6PDX; P4HA1A; LEPREL1

    CYP24A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP24A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP24A1.

    Dlg4; ECSIT

    Sidhu, PS; Teske, K; et al. Anticancer activity of VDR-coregulator inhibitor PS121912. CANCER CHEMOTHERAPY AND PHARMACOLOGY 74:787-798(2014).
    Girgis, CM; Mokbel, N; et al. The Vitamin D Receptor (VDR) Is Expressed in Skeletal Muscle of Male Mice and Modulates 25-Hydroxyvitamin D (25OHD) Uptake in Myofibers. ENDOCRINOLOGY 155:3227-3237(2014).

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