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CYP39A1

Official Full Name

cytochrome P450, family 39, subfamily A, polypeptide 1
Overview

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol.
Synonyms

CYP39A1; cytochrome P450, family 39, subfamily A, polypeptide 1; cytochrome P450, subfamily XXXIX (oxysterol 7 alpha hydroxylase), polypeptide 1; 24-hydroxycholesterol 7-alpha-hydroxylase; hCYP39A1; cytochrome P450 39A1; oxysterol 7alpha-hydroxylase; oxys;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CYP39A1-2272H	Recombinant Human CYP39A1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CYP39A1-3413H	Recombinant Human CYP39A1 protein, His-tagged	E.coli	His	18-274 aa	$319 / 25ug
Human	CYP39A1-2398HF	Recombinant Full Length Human CYP39A1 Protein, GST-tagged	In Vitro Cell Free System	GST	469 amino acids	Inquiry
Rhesus Macaque	CYP39A1-1157R	Recombinant Rhesus monkey CYP39A1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	CYP39A1-982R	Recombinant Rhesus Macaque CYP39A1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	CYP39A1-982R-B	Recombinant Rhesus Macaque CYP39A1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	CYP39A1-3295Z	Recombinant Zebrafish CYP39A1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CYP39A1 involved in several pathways and played different roles in them. We selected most pathways CYP39A1 participated on our site, such as Primary bile acid biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP39A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Primary bile acid biosynthesis	CYP46A1;HSD3B7;CYP39A1;CYP46A1.1;CYP46A1.3;CH25H;SCP2;BRSK2;CYP7B1

CYP39A1 has several biochemical functions, for example, heme binding, iron ion binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP39A1 itself. We selected most functions CYP39A1 had, and list some proteins which have the same functions with CYP39A1. You can find most of the proteins on our site.

Function	Related Protein
heme binding	CYP2A6;CYP46A1.3;CYBB;CYP2H1;CYP2AA4;CYP19A1A;HBB-B2;CYCS;HBB
iron ion binding	CYP2P9;TPH2;FTH1;CYP2AA1;POR;ALOX5B.2;C14orf169;CYP2AD3;CYP3A25
metal ion binding	CYP2C54;CTDSP1;PRKCDA;ZNF239;ZNF711;ZNF395;ZSCAN16;ATF7;ZNF565
monooxygenase activity	CYP2AA9;YWHAQA;CYP46A1.4;YWHAE1;CYP19A1B;CYP2AA4;CYP4F3;BCMO1;CYP2K19
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	CYP46A1.1;OGFOD2;CYP8B2;CYP46A1.2;CYP2A12;CYP19A1B;CYP2C37;CYP4V7;CYP7A1A

CYP39A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP39A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP39A1.