CYP4F12

  • Official Full Name

    cytochrome P450, family 4, subfamily F, polypeptide 12
  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid; however, its physiological function has not been determined. This gene is part of a cluster of cytochrome P450 genes on chromosome 19.
  • Synonyms

    CYP4F12;cytochrome P450, family 4, subfamily F, polypeptide 12;cytochrome P450, subfamily IVF, polypeptide 12;cytochrome P450 4F12;CYPIVF12;F22329_1

Recombinant Proteins

  • Rhesus macaque
  • Human
  • Cynomolgus
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • E.coli
  • His
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
CYP4F12-1162R Recombinant Rhesus monkey CYP4F12 Protein, His-tagged Mammalian Cells Rhesus macaque His
CYP4F12-2283H Recombinant Human CYP4F12 Protein, GST-tagged Wheat Germ Human GST
CYP4F12-446C Recombinant Cynomolgus CYP4F12 Protein, His-tagged Mammalian Cells Cynomolgus His
CYP4F12-7102HCL Recombinant Human CYP4F12 293 Cell Lysate HEK293 Human Non
CYP4F12-192C Recombinant Cynomolgus Monkey CYP4F12 Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus Avi&Fc&His
CYP4F12-192C-B Recombinant Cynomolgus Monkey CYP4F12 Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus
CYP4F12-2443HF Recombinant Full Length Human CYP4F12 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 524 amino acids
CYP4F12-987R Recombinant Rhesus Macaque CYP4F12 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
CYP4F12-987R-B Recombinant Rhesus Macaque CYP4F12 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
RFL14747HF Recombinant Full Length Human Cytochrome P450 4F12(Cyp4F12) Protein, His-Tagged E.coli Human His Full L. Full Length (1-524)

    Involved Pathway

    CYP4F12 involved in several pathways and played different roles in them. We selected most pathways CYP4F12 participated on our site, such as Biological oxidations,Cytochrome P450 - arranged by substrate type,Eicosanoids, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4F12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism AKR1C21,SLC5A6B,Sult2a2,CYP2B6,SLC25A16,TACO1,LPA,LYRM4,COX11,ACSF3
    Phase 1 - Functionalization of compounds CYP2Y3,CYP3C1,CYP2N13,CYP2K18,ADH8A,CYP2AD3,CYP2A7,CYP2K16,CYP2R1,CYP2K17
    Cytochrome P450 - arranged by substrate type CYP2Y3,CYP4F11,CYP2K22,CYP1A1,CYP26A1,FDXR,CYP2C8,CYP2U1,CYP46A1,CYP2S1
    Fatty acids CYP4A11,CYP2N13,CYP4T8,CYP4B1,CYP4F11,CYP2AD2,CYP4F22,CYP2AD3,CYP2A7,CYP2B6
    Tryptophan metabolism ALDH2.1,ALDH1B1,GCDHA,ALDH2.2,ALDH9A1A.1,INMT,AANAT1,HADHAB,ALDH9A1,ACAT2
    Eicosanoids CYP4F22,CYP4B1,CYP4A11,CYP4F11
    cytochrome P450 CYP4Z1,CYP2W1,CYB5A,CYB5B,CYP2A7,POR,CYP20A1,CYP4V2,CYB5R3
    Biological oxidations CYP26A1,GSTO2,CYP3A5,CYP1A2,CYP17A1,UGT1B2,NAT2,CYP3A7-CYP3AP1,GGTLC1,CYP2W1

    Protein Function

    CYP4F12 has several biochemical functions, for example, alkane 1-monooxygenase activity,arachidonic acid epoxygenase activity,aromatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4F12 itself. We selected most functions CYP4F12 had, and list some proteins which have the same functions with CYP4F12. You can find most of the proteins on our site.

    Function Related Protein
    iron ion binding CYP2X9,PDF,CYP27A1,PTGIS,P4HA1A,CYP2AA3,LEPREL2,BRSK2,HBD,CYP26A1
    arachidonic acid epoxygenase activity CYP2C39,CYP4A10,CYP2C18,CYP2F1,CYP2C55,CYP2C19,CYP2AA4,CYP2C54,CYP2J2,CYP2AA2
    aromatase activity CYP2H1,CYP2A7,CYP4B1,CYP2C39,CYP2U1,CYP2J5,CYP2C9,CYP1A4,CYP2A12,CYP2C38
    heme binding CYP2AD6,CYP17A1,CYP1D1,CYP11C1,CYP8B1,JAK2,CYP11B1,CYP2AA9,CYP1C1,CYP19A1
    leukotriene-B4 20-monooxygenase activity CYP4F3,CYP4A11,CYP4F2,CYP4F14,CYP4A10,CYP4F18
    alkane 1-monooxygenase activity CYP4A10,CYP4A14,CYP4F18,CYP4A12A,CYP4F2,CYP4A11

    Interacting Protein

    CYP4F12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4F12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4F12.

    saicar;PKM;SOD2;HSPA6

    Resources

    References

    • Redlich, G; Zanger, UM; et al. Distinction between Human Cytochrome P450 (CYP) Isoforms and Identification of New Phosphorylation Sites by Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH 7:4678-4688(2008).
    • Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).

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