CYTH1

  • Official Full Name

    cytohesin 1

  • Overview

    The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83% homologous to that of CYTH2.
  • Synonyms

    CYTH1; cytohesin 1; pleckstrin homology, Sec7 and coiled coil domains 1 , PSCD1; cytohesin-1; B2 1; D17S811E; cytoadhesin 1; SEC7 homolog B2-1; homolog of secretory protein SEC7; pleckstrin homology, Sec7 and coiled-coil domains 1; PH, SEC7 and coiled-coi;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYTH1-85H Recombinant Human CYTH1, His-tagged E.coli His
Human CYTH1-7095HCL Recombinant Human CYTH1 293 Cell Lysate HEK293 N/A
Human CYTH1-1881HFL Recombinant Full Length Human CYTH1 Protein, C-Flag-tagged Mammalian cells Flag
Human CYTH1-2270H Recombinant Human CYTH1 Protein (Met1-His398), N-His tagged E.coli N-His Met1-His398
Human CYTH1-710H Recombinant Human CYTH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CYTH1-710H-B Recombinant Human CYTH1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cyth1-2428M Recombinant Mouse Cyth1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat CYTH1-1763R Recombinant Rat CYTH1 Protein Mammalian Cell His
Rat CYTH1-1421R-B Recombinant Rat CYTH1 Protein Pre-coupled Magnetic Beads HEK293
Rat CYTH1-1421R Recombinant Rat CYTH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CYTH1-1168R Recombinant Rhesus monkey CYTH1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CYTH1-993R Recombinant Rhesus Macaque CYTH1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CYTH1-993R-B Recombinant Rhesus Macaque CYTH1 Protein Pre-coupled Magnetic Beads HEK293
Chicken CYTH1-2779C Recombinant Chicken CYTH1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CYTH1 involved in several pathways and played different roles in them. We selected most pathways CYTH1 participated on our site, such as Phospholipase D signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYTH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Phospholipase D signaling pathwayINS;CXCR1;PIP5K1A;GAB1;MTOR;AGPAT5;INSR;MAPK1;ARF6
EndocytosisIL2RGA;GIT1;ACAP2;CSF1RA;ASAP2A;CSF1R;ARRB2A;AP2M1A;DNM1B

CYTH1 has several biochemical functions, for example, ARF guanyl-nucleotide exchange factor activity, lipid binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYTH1 itself. We selected most functions CYTH1 had, and list some proteins which have the same functions with CYTH1. You can find most of the proteins on our site.

Function Related Protein
ARF guanyl-nucleotide exchange factor activityMON2;CYTH3;GBF1;PSD4;CYTH1A;CYTH4;CYTH2;CYTH1;CYTH1B
lipid bindingAPOA1B;LPAR2;PAQR7B;FFAR1;CRABP1A;VCP;PPARD;S1PR2;STARD6
protein bindingRAB1B;C19orf60;CBFA2T2;DNAJC11;RPL30;ARL2BP;MAPK3;RNF41;CBR4

CYTH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYTH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYTH1.

saicar; ITGB2; PKM; CYTIP; 1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate

Research Area

Related articles

El Azreq, MA; Bourgoin, SG; et al. Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through beta 2 integrin activation. MOLECULAR IMMUNOLOGY 48:1408-1416(2011).
Sendide, K; Reiner, NE; et al. Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: Regulation by phosphatidylinositol 3-kinase and cytohesin-1. JOURNAL OF IMMUNOLOGY 174:4210-4219(2005).
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