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CYTH3

Official Full Name

cytohesin 3
Overview

This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.
Synonyms

CYTH3; cytohesin 3; pleckstrin homology, Sec7 and coiled coil domains 3 , PSCD3; cytohesin-3; ARNO3; GRP1; ARF nucleotide-binding site opener 3; ARNO3 protein; OTTHUMP00000115876; general receptor of phosphoinositides 1; pleckstrin homology, Sec7 and coiled-coil domains 3; PH, SEC7 and coiled-coil domain-containing protein 3; PSCD3;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Wheat Germ

Tag

GST
His
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CYTH3-165H	Recombinant Human CYTH3, His-tagged	E.coli	His	1-399aa	Inquiry
Human	CYTH3-11803H	Recombinant Human CYTH3, GST-tagged	E.coli	GST	C-term-179a.a.	$319 / 25ug
Human	CYTH3-2305H	Recombinant Human CYTH3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CYTH3-1425HCL	Recombinant Human CYTH3 cell lysate		N/A		Inquiry
Human	CYTH3-1159H	Recombinant Human CYTH3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	CYTH3-3400H	Recombinant Human CYTH3 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	CYTH3-2501HF	Recombinant Full Length Human CYTH3 Protein, GST-tagged	In Vitro Cell Free System	GST	179 amino acids	Inquiry
Mouse	Cyth3-2430M	Recombinant Mouse Cyth3 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CYTH3 Related Articles

CYTH3 involved in several pathways and played different roles in them. We selected most pathways CYTH3 participated on our site, such as Phospholipase D signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYTH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phospholipase D signaling pathway	AGTR1A;RHEB;INSR;PIK3R1;PTK2B;FYN;PTPN11;SOS1;PIK3R3
Endocytosis	HSP70;PSD2;ZFYVE20;GIT2;EPS15L1;RAB10;SH3GL3A;HLA-A;VPS4B

CYTH3 has several biochemical functions, for example, ARF guanyl-nucleotide exchange factor activity, phosphatidylinositol-3,4,5-trisphosphate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYTH3 itself. We selected most functions CYTH3 had, and list some proteins which have the same functions with CYTH3. You can find most of the proteins on our site.

Function	Related Protein
ARF guanyl-nucleotide exchange factor activity	GBF1;CYTH1B;CYTH1A;CYTH4B;IQSEC1;PSD3;PSD2;CYTH2;PSD4
phosphatidylinositol-3,4,5-trisphosphate binding	PHLDA3;GAB2;FAM21C;BTK;ARAP3;AKT1;ARAP1;NRGN;ZFYVE1
protein binding	GLYAT;TMEM242;AKIP1;ASAP2;KRT4;MAP4K5;PPP2R2C;TIMM21;LRDD

CYTH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYTH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYTH3.

CNKSR1; SYCE1; CCDC120; CALCOCO1

El Azreq, MA; Bourgoin, SG; et al. Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through beta 2 integrin activation. MOLECULAR IMMUNOLOGY 48:1408-1416(2011).

Sendide, K; Reiner, NE; et al. Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: Regulation by phosphatidylinositol 3-kinase and cytohesin-1. JOURNAL OF IMMUNOLOGY 174:4210-4219(2005).