DARC involved in several pathways and played different roles in them. We selected most pathways DARC participated on our site, such as Malaria, which may be useful for your reference. Also, other proteins which involved in the same pathway with DARC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Malaria |
HGF; TLR9; KLRC4-KLRK1; COMP; IL12A; DARC; ITGAL; IL1B; TGFB1; HBA-A2 |
DARC has several biochemical functions, for example, C-C chemokine binding, G-protein coupled receptor activity, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DARC itself. We selected most functions DARC had, and list some proteins which have the same functions with DARC. You can find most of the proteins on our site.
| Function |
Related Protein |
| C-C chemokine binding |
CCR1; ZFP36; DARC; CCR5; CCBP2 |
| G-protein coupled receptor activity |
MTNR1AL; OPN4XB; FZD7; TAAR8B; TAS2R137; GPR25; OLFR147; F2RL1.1; TAAR7D; FZD9B |
| receptor activity |
TREM1; GRIA2A; PAQR5B; NEO1; NOTCH4; MED24; IL18R1; CD160; ITGB8; EXTL3 |
| transmembrane signaling receptor activity |
AGER; KIR2DL4; OR6K3; OR4C13; LILRA1; ERBB3; EMR4; ADCYAP1R1A; TNFRSF8; KLRC2 |
DARC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DARC here. Most of them are supplied by our site. Hope this information will be useful for your research of DARC.
Meyer, S; Vollmert, C; et al. High-throughput Kell, Kidd, and Duffy matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry-based blood group genotyping of 4000 donors shows close to full concordance with serotyping and detects new alleles. TRANSFUSION 54:3198-3207(2014).
de Sousa, TN; Kano, FS; et al. The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon. MEMORIAS DO INSTITUTO OSWALDO CRUZ 109:608-617(2014).
