DARC Protein


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Official Full Name Duffy blood group, chemokine receptor
Background The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms DARC; Duffy blood group, chemokine receptor; Duffy blood group , FY; Duffy antigen/chemokine receptor; CCBP1; CD234; Dfy; GPD; glycoprotein D; Fy glycoprotein; Duffy blood group antigen; plasmodium vivax receptor; FY; GpFy; WBCQ1
    • Species :
    • Human
    • Source :
    • E.coli
    • In Vitro Cell Free System
    • Wheat Germ
    • Tag :
    • GST
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DARC-26807TH Recombinant Human DARC Wheat Germ N/A Inquiry
    Human DARC-115HF Recombinant Full Length Human DARC Protein In Vitro Cell Free System Inquiry
    Human DARC-1312H Recombinant Human DARC Protein, His-tagged E.coli N-His Inquiry
    Human DARC-5281HF Recombinant Full Length Human DARC Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Human DARC-6856HF Recombinant Full Length Human DARC Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Human DARC-26807H Recombinant Human DARC Protein Wheat Germ Inquiry
    Human DARC-4582H Recombinant Human DARC Protein, GST-tagged Wheat Germ GST Inquiry
    Kit-1210 DARC CHO-K1 β-Arrestin Orphan GPCR Assay Kit N/A Inquiry

    DARC involved in several pathways and played different roles in them. We selected most pathways DARC participated on our site, such as Malaria, which may be useful for your reference. Also, other proteins which involved in the same pathway with DARC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    DARC has several biochemical functions, for example, C-C chemokine binding, G-protein coupled receptor activity, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DARC itself. We selected most functions DARC had, and list some proteins which have the same functions with DARC. You can find most of the proteins on our site.

    Function Related Protein
    C-C chemokine binding CCR1; ZFP36; DARC; CCR5; CCBP2
    G-protein coupled receptor activity MTNR1AL; OPN4XB; FZD7; TAAR8B; TAS2R137; GPR25; OLFR147; F2RL1.1; TAAR7D; FZD9B
    receptor activity TREM1; GRIA2A; PAQR5B; NEO1; NOTCH4; MED24; IL18R1; CD160; ITGB8; EXTL3
    transmembrane signaling receptor activity AGER; KIR2DL4; OR6K3; OR4C13; LILRA1; ERBB3; EMR4; ADCYAP1R1A; TNFRSF8; KLRC2

    DARC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DARC here. Most of them are supplied by our site. Hope this information will be useful for your research of DARC.

    Meyer, S; Vollmert, C; et al. High-throughput Kell, Kidd, and Duffy matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry-based blood group genotyping of 4000 donors shows close to full concordance with serotyping and detects new alleles. TRANSFUSION 54:3198-3207(2014).
    de Sousa, TN; Kano, FS; et al. The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon. MEMORIAS DO INSTITUTO OSWALDO CRUZ 109:608-617(2014).

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