DBF4
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Official Full Name
DBF4 homolog -
Overview
Protein DBF4 homolog A is a protein that in humans is encoded by the DBF4 gene. -
Synonyms
DBF4;DBF4 homolog (S. cerevisiae);protein DBF4 homolog A;activator of S phase kinase;ASK;chif;chiffon homolog (Drosophila);DBF4A;ZDBF1;zinc finger;DBF type containing 1;chiffon homolog A;zinc finger, DBF-type containing 1;DBF4-type zinc finge
Recombinant Proteins
- Human
- Zebrafish
- Wheat Germ
- Mammalian Cells
- HEK293
- E.coli
- GST
- His
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ASK-908H | Recombinant Human ASK protein, GST-tagged | Wheat Germ | Human | GST |
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| DBF4-689H | Recombinant Human DBF4 | Mammalian Cells | Human | His |
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| DBF4-7188Z | Recombinant Zebrafish DBF4 | Mammalian Cells | Zebrafish | His |
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| DBF4-7067HCL | Recombinant Human DBF4 293 Cell Lysate | HEK293 | Human | Non |
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| DBF4-2777H | Recombinant Human DBF4 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| DBF4-2777H-B | Recombinant Human DBF4 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| DBF4-6842H | Recombinant Human DBF4 protein, His-tagged | E.coli | Human | His | 253-410 aa |
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| DBF4-6843H | Recombinant Human DBF4 protein, GST-tagged | E.coli | Human | GST | 253-410 aa |
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Involved Pathway
DBF4 involved in several pathways and played different roles in them. We selected most pathways DBF4 participated on our site, such as Activation of ATR in response to replication stress,Activation of the pre-replicative complex,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with DBF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell Cycle, Mitotic | NEDD1,CLASP1A,CENPO,NINL,LIN52,FGFR1OP,MASTL,PANE1,PMF1,CLASP1 |
| Cell cycle | ACTR1A,TOP2A,CENPW,MCM5,ERCC6L,ANAPC5,DCTN2,VRK1,CDC16,E2F5 |
| Activation of ATR in response to replication stress | RAD9B,CHEK1,RAD9,CLSPN,RAD17,RAD9A,MCM8,RAD1,HUS1,CDK2 |
| DNA Replication Pre-Initiation | GMNN,CDT1,MCM10 |
| Cell Cycle Checkpoints | UBE2V2,HUS1,BRCC3,RAD17,RNF168,RAD9B,THRSP,RAD50,CDK2,CHEK2 |
| Activation of the pre-replicative complex | MCM10,CDT1,CDK2,MCM8 |
| DNA Replication | LIG1,POLE2,GMNN,FEN1,POLD4,RPA4,MCM3,DNA2,POLE,MCM10 |
Protein Function
DBF4 has several biochemical functions, for example, enzyme activator activity,nucleic acid binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DBF4 itself. We selected most functions DBF4 had, and list some proteins which have the same functions with DBF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | FHL5,LMO4,CA15C,POLR2K,TRAF7,MICAL1,LTN1,SIVA1,APIP,MSL2B |
| enzyme activator activity | DNMT3L,MMP16,CASP9,MGST2,DBNL,PITRM1,MMP24,RICTOR,GLC8,PSAP |
| nucleic acid binding | GTF2H2,TSEN2,RBAK,ZXDB,ZBTB2B,METTL5,REV3L,TDRKH,MTERFD3,DDX39 |
Interacting Protein
DBF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DBF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DBF4.
CDC7;CHAF1A;LSM8
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References
- Charych, DH; Coyne, M; et al. Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells. JOURNAL OF CELLULAR BIOCHEMISTRY 104:1075-1086(2008).
- Tsuji, T; Ficarro, SB; et al. Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. MOLECULAR BIOLOGY OF THE CELL 17:4459-4472(2006).
