DDX41
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Official Full Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 -
Overview
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression. -
Synonyms
DDX41;DEAD (Asp-Glu-Ala-Asp) box polypeptide 41;probable ATP-dependent RNA helicase DDX41;AI324246;zgc:55896;2900024F02Rik;AA958953;ABS;DEAD box protein 41;DEAD box protein abstrakt homolog;EC 3.6.1.-;fb92e02;MGC55896;MGC8828;wu:fb92e02;OTTHUMP00000161451;OTTHUMP00000223824;putative RNA helicase;DEAD-box protein abstrakt
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- DDK
- Myc
- Non
- Flag
- Avi
- Fc
Involved Pathway
DDX41 involved in several pathways and played different roles in them. We selected most pathways DDX41 participated on our site, such as Cytosolic sensors of pathogen-associated DNA,IRF3-mediated induction of type I IFN,Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX41 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| IRF3-mediated induction of type I IFN | IFI16,NLRP4C,TREX1,NLRP4B,NLRP4,NLRP4E |
| Cytosolic sensors of pathogen-associated DNA | AGER,NLRP4E,CRCP,TREX1,TRIM56,POLR3G,RIPK3,POLR3H,APPB,SAA1 |
| Immune System | WIPF2,SEC24A,KIF3C,TRIM11,WSB1,RACGAP1,DZIP3,BFB,S100B,VPRBP |
| Regulation of innate immune responses to cytosolic DNA | NLRP4,NLRP4E,NLRP4B,TREX1,TRIM56,NLRP4C |
| Innate Immune System | TAX1BP1,FAM49BA,CD300E,ALCAMB,NLRP4C,TAX1BP1B,BFB,LAT2,BTR30,SIGLEC14 |
| STING mediated induction of host immune responses | NLRP4C,IFI16,MB21D1,TREX1,NLRP4,NLRP4B,NLRP4E |
Protein Function
DDX41 has several biochemical functions, for example, ATP binding,ATP-dependent RNA helicase activity,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX41 itself. We selected most functions DDX41 had, and list some proteins which have the same functions with DDX41. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP-dependent RNA helicase activity | DDX17,DDX21,DDX39AA,DDX46,DHX15,DDX50,PL10,DDX39,YTHDC2,DHX32 |
| DNA binding | ZNF230,FOXF1,ZNF131,HIST4H4,NR5A5,EEF1D,RCAN1,PHTF2,NR1D2B,ZNF37A |
| protein binding | TRAPPC10,MYH8,TTK,RPRD1A,PKN1,C7orf31,KIF4A,USP13,PIK3R2,PLEKHB2 |
| poly(A) RNA binding | RPL26L1,PRPF3,HSPE1,ANXA11,DDX47,PUF60,LSM14A,PPHLN1,SLIRP,POP7 |
| zinc ion binding | PDXK,RERE,SIRT6,PHF23B,BRF1,Ar,TRIM54,TRIM10,CA3,TRIM44 |
| ATP binding | MAPK12A,HLTF,AXL,DHX35,MYLK,DSTYK,MAP3K4,HSC70,ADCY7,TSSK4 |
Interacting Protein
DDX41 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX41 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX41.
SIAH1;CEP70;NKAP;ABL1;FYN;CRK;RNPS1;Ddx41;USP36;gltX;E2F3;DVL2;ANXA1;SNW1;Vps41
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