|Official Full Name||Der1-like domain family, member 3|
|Background||The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene.|
|Synonyms||DERL3; Der1-like domain family, member 3; C22orf14, chromosome 22 open reading frame 14; derlin-3; derlin 3; FLJ43842; IZP6; MGC71803; C22orf14; Degradation in endoplasmic reticulum protein 3; DER 3; Der1 like domain family member 3; Der1 like protein 3; Der1-like protein 3; DER3; DERL 3; DERL3_HUMAN; Derlin 3 protein; Derlin3; DERtrin 3; DERtrin-3; DERtrin3; IZP 6; LLN 2; LLN2|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
derl3 involved in several pathways and played different roles in them. We selected most pathways derl3 participated on our site, such as Apoptosis, Apoptosis Modulation by HSP70, Ceramide signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with derl3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Apoptosis||DBNLA; PPP3CA; OCLN; ENDOG; CRADD; NGF; CAPN1A; YWHAQ; PPP3CCA; HELLS|
|Apoptosis Modulation by HSP70||CASP2; DERL3|
|Ceramide signaling pathway||DERL3; EGF; CTSD; PAWR; CRADD|
derl3 has several biochemical functions, for example, DNA binding, FAD binding, NAD(P)H oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by derl3 itself. We selected most functions derl3 had, and list some proteins which have the same functions with derl3. You can find most of the proteins on our site.
|DNA binding||PRM2; HOXA11B; HP1BP3; HOXC9; EEPD1; POLR2K; GLYR1; RAD51B; GSX2; POLR3K|
|FAD binding||MICAL1; MICAL2; CYB5R3; ACOX1; DAO.1; DAO.2; KMO; DAO; AGPS; MICAL2B|
|NAD(P)H oxidase activity||KMO; AIFM1; CYB5R4; DUOX2; NOX4; DERL3|
|electron carrier activity||IDH3B; UQCR11; DERL3; ACAD11; GLRX3; ACOX2; NCF1; NDUFS3; LOXL2; AOC2|
|oxidoreductase activity, acting on NAD(P)H||NDUFS8A; WDR93; ECSIT; NDUFS8B; DERL3; AIFM1; DECR1; MIOX|
|protein binding||BRPF1; MEOX2; CDC42EP1; GRHL3; SYNE1; MRAP; EIF5B; ZNF167; FAM162A; PTPN9|
|protein dimerization activity||MYCH; ID2B; MESPBA; PDCD6; TCF21; STK3; SRFB; NCF4; HEY2; ASCL3|
derl3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with derl3 here. Most of them are supplied by our site. Hope this information will be useful for your research of derl3.