DLX5
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Official Full Name
distal-less homeobox 5 -
Overview
This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. -
Synonyms
DLX5;distal-less homeobox 5;distal less homeo box 5;homeobox protein DLX-5;distal-less homeo box 5;split hand/foot malformation type 1 with sensorineural hearing loss;SHFM1D
Recombinant Proteins
- Rat
- Human
- Mouse
- Chicken
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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DLX5-1889R | Recombinant Rat DLX5 Protein | Mammalian Cells | Rat | His |
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DLX5-28H | Recombinant Human DLX5 protein, GST-tagged | Wheat Germ | Human | GST | 1-289 a.a. |
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DLX5-2926H | Recombinant Human Distal-less Homeobox 5, His-tagged | E.coli | Human | His | 1-289 a.a. |
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DLX5-4638M | Recombinant Mouse DLX5 Protein | Mammalian Cells | Mouse | His |
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DLX5-5735C | Recombinant Chicken DLX5 | Mammalian Cells | Chicken | His |
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DLX5-6903HCL | Recombinant Human DLX5 293 Cell Lysate | HEK293 | Human | Non |
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DLX5-1548R | Recombinant Rat DLX5 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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DLX5-1548R-B | Recombinant Rat DLX5 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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DLX5-2407M | Recombinant Mouse DLX5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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DLX5-2407M-B | Recombinant Mouse DLX5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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DLX5-301106H | Recombinant Human DLX5 protein, GST-tagged | E.coli | Human | GST | Met1-Tyr289 |
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DLX5-600HF | Recombinant Full Length Human DLX5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 289 amino acids |
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Involved Pathway
DLX5 involved in several pathways and played different roles in them. We selected most pathways DLX5 participated on our site, such as Neural Crest Differentiation,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with DLX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Neural Crest Differentiation | CDH7,FOXD3,LHX2,HEY2,OLIG1,SOX5,ZIC1,MIA,OLIG3,ASCL1 |
Signaling pathways regulating pluripotency of stem cells | WNT6,SKIL,MAPK3,HAND1,SMAD2,ACVR2A,INHBA,WNT1,MAP2K2,NANOG |
Protein Function
DLX5 has several biochemical functions, for example, HMG box domain binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,transcription regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DLX5 itself. We selected most functions DLX5 had, and list some proteins which have the same functions with DLX5. You can find most of the proteins on our site.
Function | Related Protein |
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transcription regulatory region DNA binding | CBX4,TP53,TFAP4,ERBB4,ATF3,AHR,SMARCA2,CDK5RAP2,NKX2,CITED1 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | ONECUT2,ZFP639,CEBPE,IFI16,NKX3-2,NACC2,ZNF264,ETV4,T,FOXJ1 |
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | GLI2,MZF1,TLX1,ZIC3,KLF13,RAX,NRL,FOXL2,NR4A1,MEIS3 |
HMG box domain binding | EGR2,GATA3,POU3F3,JUN,UTF1,SP1,CEBPA,PRRX1,HOXC4,MEOX1 |
Interacting Protein
DLX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DLX5.
Resources
Research Area
Osteoclast MarkersTranscription Factors in the Akt Pathway
Cancer Stem Cell Transcription Factors
Osteoblast and Osteoclast Markers
Related Services
Related Products
References
- Senga, Y; Yoshioka, K; et al. Expression and gene knockdown of zebrafish Ca2+/calmodulin-dependent protein kinase I delta-LL. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 540:41-52(2013).
- Scullen, T; Santo, L; et al. Lenalidomide in combination with an activin A-neutralizing antibody: preclinical rationale for a novel anti-myeloma strategy. LEUKEMIA 27:1715-1721(2013).