DLX5

  • Official Full Name

    distal-less homeobox 5
  • Overview

    This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation.
  • Synonyms

    DLX5;distal-less homeobox 5;distal less homeo box 5;homeobox protein DLX-5;distal-less homeo box 5;split hand/foot malformation type 1 with sensorineural hearing loss;SHFM1D

Recombinant Proteins

  • Rat
  • Human
  • Mouse
  • Chicken
  • Mammalian Cells
  • Wheat Germ
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
DLX5-1889R Recombinant Rat DLX5 Protein Mammalian Cells Rat His
DLX5-28H Recombinant Human DLX5 protein, GST-tagged Wheat Germ Human GST 1-289 a.a.
DLX5-2926H Recombinant Human Distal-less Homeobox 5, His-tagged E.coli Human His 1-289 a.a.
DLX5-4638M Recombinant Mouse DLX5 Protein Mammalian Cells Mouse His
DLX5-5735C Recombinant Chicken DLX5 Mammalian Cells Chicken His
DLX5-6903HCL Recombinant Human DLX5 293 Cell Lysate HEK293 Human Non
DLX5-1548R Recombinant Rat DLX5 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
DLX5-1548R-B Recombinant Rat DLX5 Protein Pre-coupled Magnetic Beads HEK293 Rat
DLX5-2407M Recombinant Mouse DLX5 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
DLX5-2407M-B Recombinant Mouse DLX5 Protein Pre-coupled Magnetic Beads HEK293 Mouse
DLX5-301106H Recombinant Human DLX5 protein, GST-tagged E.coli Human GST Met1-Tyr289
DLX5-600HF Recombinant Full Length Human DLX5 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 289 amino acids

    Involved Pathway

    DLX5 involved in several pathways and played different roles in them. We selected most pathways DLX5 participated on our site, such as Neural Crest Differentiation,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with DLX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neural Crest Differentiation CDH7,FOXD3,LHX2,HEY2,OLIG1,SOX5,ZIC1,MIA,OLIG3,ASCL1
    Signaling pathways regulating pluripotency of stem cells WNT6,SKIL,MAPK3,HAND1,SMAD2,ACVR2A,INHBA,WNT1,MAP2K2,NANOG

    Protein Function

    DLX5 has several biochemical functions, for example, HMG box domain binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,transcription regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DLX5 itself. We selected most functions DLX5 had, and list some proteins which have the same functions with DLX5. You can find most of the proteins on our site.

    Function Related Protein
    transcription regulatory region DNA binding CBX4,TP53,TFAP4,ERBB4,ATF3,AHR,SMARCA2,CDK5RAP2,NKX2,CITED1
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ONECUT2,ZFP639,CEBPE,IFI16,NKX3-2,NACC2,ZNF264,ETV4,T,FOXJ1
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GLI2,MZF1,TLX1,ZIC3,KLF13,RAX,NRL,FOXL2,NR4A1,MEIS3
    HMG box domain binding EGR2,GATA3,POU3F3,JUN,UTF1,SP1,CEBPA,PRRX1,HOXC4,MEOX1

    Interacting Protein

    DLX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DLX5.

    Resources

    References

    • Senga, Y; Yoshioka, K; et al. Expression and gene knockdown of zebrafish Ca2+/calmodulin-dependent protein kinase I delta-LL. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 540:41-52(2013).
    • Scullen, T; Santo, L; et al. Lenalidomide in combination with an activin A-neutralizing antibody: preclinical rationale for a novel anti-myeloma strategy. LEUKEMIA 27:1715-1721(2013).

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