|Official Full Name||doublesex and mab-3 related transcription factor 1|
|Background||This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like;DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining;pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific;and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene;is hemizygous.|
|Synonyms||DMRT1; doublesex and mab-3 related transcription factor 1; doublesex- and mab-3-related transcription factor 1; DM domain expressed in testis 1; DMT1; DM domain expressed in testis protein 1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
dmrt1 involved in several pathways and played different roles in them. We selected most pathways dmrt1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with dmrt1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
dmrt1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, chromatin binding, core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by dmrt1 itself. We selected most functions dmrt1 had, and list some proteins which have the same functions with dmrt1. You can find most of the proteins on our site.
|RNA polymerase II regulatory region sequence-specific DNA binding||ZFY2; RELA; GATA4; TFAP2E; OSR2; GATA2; CDX1A; EAF2; ARID3A; MEF2A|
|chromatin binding||ZNF143; EOMES; MTA1; SHMT2; COQ7; SMAD4; PPARGC1A; APBB1; TBL1Y; PRKCBB|
|core promoter proximal region sequence-specific DNA binding||MEF2C; DMRTA1; CREBBP; GATA3; KLF4; DMRT3; SMAD4; SMAD3; DMRTC1B; DMRT2A|
|metal ion binding||ZNF45L; PGGT1B; KLF10; SDHC; MGAT4C; ZFP326; DMRTA2; KCNIP1B; KLF11A; ARAF|
|protein heterodimerization activity||H2-Q10; ZHX1; ADRB1; PANX1; PPP1CBL; BNIP3L; PHC2B; CENPA; DRD2; DR1|
|protein homodimerization activity||BMPR1A; OLFM4; ANXA1; FGFR1OP2; EIF2AK3; GLIPR2; TBX1; SRR; ACOT7; MTHFD1L|
|transcription factor activity, sequence-specific DNA binding||Ar; ZNF383; ZKSCAN4; SCML1; IRF9; UBN2; FOXH1; HOXC6B; NR2F5; FOXS1|
|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding||RFX6; MAFK; GRHL3; SOHLH2; BARHL1B; LEF1; MYOCD; MAFG; MAFGB; HSF2|
dmrt1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dmrt1 here. Most of them are supplied by our site. Hope this information will be useful for your research of dmrt1.