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Official Full Name doublesex and mab-3 related transcription factor 1
Background This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like;DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining;pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific;and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene;is hemizygous.
Synonyms DMRT1; doublesex and mab-3 related transcription factor 1; doublesex- and mab-3-related transcription factor 1; DM domain expressed in testis 1; DMT1; DM domain expressed in testis protein 1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Dmrt1-2587M Recombinant Mouse Dmrt1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human DMRT1-6242H Recombinant Human DMRT1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human DMRT1-27093TH Recombinant Human DMRT1 Wheat Germ N/A
    Human DMRT1-2709H Recombinant Human DMRT1 Protein, GST-tagged Wheat Germ GST
    Human DMRT1-6898HCL Recombinant Human DMRT1 293 Cell Lysate HEK293 N/A
    Mouse DMRT1-4649M Recombinant Mouse DMRT1 Protein Mammalian Cell His
    Chicken DMRT1-3742C Recombinant Chicken DMRT1 Mammalian Cell His
    Zebrafish DMRT1-11663Z Recombinant Zebrafish DMRT1 Mammalian Cell His
    Zebrafish DMRT1-11775Z Recombinant Zebrafish DMRT1 Mammalian Cell His

    dmrt1 involved in several pathways and played different roles in them. We selected most pathways dmrt1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with dmrt1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    dmrt1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, chromatin binding, core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by dmrt1 itself. We selected most functions dmrt1 had, and list some proteins which have the same functions with dmrt1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II regulatory region sequence-specific DNA binding ZFY2; RELA; GATA4; TFAP2E; OSR2; GATA2; CDX1A; EAF2; ARID3A; MEF2A
    chromatin binding ZNF143; EOMES; MTA1; SHMT2; COQ7; SMAD4; PPARGC1A; APBB1; TBL1Y; PRKCBB
    core promoter proximal region sequence-specific DNA binding MEF2C; DMRTA1; CREBBP; GATA3; KLF4; DMRT3; SMAD4; SMAD3; DMRTC1B; DMRT2A
    metal ion binding ZNF45L; PGGT1B; KLF10; SDHC; MGAT4C; ZFP326; DMRTA2; KCNIP1B; KLF11A; ARAF
    protein heterodimerization activity H2-Q10; ZHX1; ADRB1; PANX1; PPP1CBL; BNIP3L; PHC2B; CENPA; DRD2; DR1
    protein homodimerization activity BMPR1A; OLFM4; ANXA1; FGFR1OP2; EIF2AK3; GLIPR2; TBX1; SRR; ACOT7; MTHFD1L
    transcription factor activity, sequence-specific DNA binding Ar; ZNF383; ZKSCAN4; SCML1; IRF9; UBN2; FOXH1; HOXC6B; NR2F5; FOXS1
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding RFX6; MAFK; GRHL3; SOHLH2; BARHL1B; LEF1; MYOCD; MAFG; MAFGB; HSF2

    dmrt1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dmrt1 here. Most of them are supplied by our site. Hope this information will be useful for your research of dmrt1.


    Li, XY; Li, Z; et al. Expression characterization of testicular DMRT1 in both Sertoli cells and spermatogenic cells of polyploid gibel carp. GENE 548:119-125(2014).
    Liu, MX; Hu, ZB; et al. Scanning of novel cancer/testis proteins by human testis proteomic analysis. PROTEOMICS 13:1200-1210(2013).

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