|Official Full Name||Desmocollin 4|
|Background||DSG4 (Desmoglein 4) is a component of intercellular desmosome junctions. DSG4 is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSG4 coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. The essential role of desmoglein 4 in skin was established by identifying mutations in families with inherited hypotrichosis, as well as in the lanceolate hair mouse. The human desmoglein 4 (DSG4) demonstrates that it is composed of 16 exons spanning approximately 37 kb of 18q12 and is situated between DSG1 and DSG3. Defects in DSG4 are the cause of localized autosomal hypotrichosis (LAH). LAH is an autosomal recessive skin disorder. DSG4 is one of the target molecules recognized by autoantibodies in patients with pemphigus vulgaris. Pemphigus vulgaris is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion.|
|Synonyms||DSG4; desmoglein 4; LAH; CDGF13; CDHF13; desmoglein-4; CDH family member 13; cadherin family member 13; OTTHUMP00000162820|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
dsg4 involved in several pathways and played different roles in them. We selected most pathways dsg4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with dsg4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
dsg4 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by dsg4 itself. We selected most functions dsg4 had, and list some proteins which have the same functions with dsg4. You can find most of the proteins on our site.
|calcium ion binding||MMP12; SYT10; DOC2D; MMP20; CAPN3B; PCDH12; PADI2; TBC1D9; SLIT2; SCIN|
dsg4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dsg4 here. Most of them are supplied by our site. Hope this information will be useful for your research of dsg4.