dusp16

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dusp16

Official Full Name dual specificity phosphatase 16
Background This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.
Synonyms DUSP16; dual specificity phosphatase 16; dual specificity protein phosphatase 16; KIAA1700; MAPK phosphatase 7; MKP 7; MKP7; MAPK phosphatase-7; MAP kinase phosphatase 7; mitogen-activated protein kinase phosphatase 7; MKP-7; FLJ36298; FLJ40991; MGC129701
    • Species :
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DUSP16-101H Recombinant Human DUSP16, GST-tagged Wheat Germ GST
    Human DUSP16-102H Recombinant Human DUSP16, GST-tagged E.coli GST
    Zebrafish DUSP16-12442Z Recombinant Zebrafish DUSP16 Mammalian Cell His

    dusp16 involved in several pathways and played different roles in them. We selected most pathways dusp16 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with dusp16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAP2K4A; FGF8; CACNA1DA; MAPK8IP3; FGF12A; TRAF2; PDGFRA; HSPA1B; RPS6KA6; AKT2L

    dusp16 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, phosphoprotein phosphatase activity, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by dusp16 itself. We selected most functions dusp16 had, and list some proteins which have the same functions with dusp16. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase tyrosine/serine/threonine phosphatase activity SACM1LA; TENC1; CTDSPL2B; DUSP14; SACM1LB; SGPP2; DUSP21; PXYLP1; DUSP10; DUSP6
    phosphoprotein phosphatase activity PHPT1; PPP3CCB; CTDNEP1; PPM1DA; PPP1CAB; DUSP22A; SSH2; PTPN2B; PTPN11B; CDC14AA
    protein tyrosine phosphatase activity PTENA; DUSP23; SSH2; PTPN20; EYA2; DUSP3B; DUPD1; SSH1; PTP4A2B; PTPRZ1
    protein tyrosine/serine/threonine phosphatase activity CTDSPL2B; PTENB; DUSP3B; CDC14AB; DUSP22B; DUSP22A; CDKN3; PXYLP1; DUSP23B; PTP4A2A

    dusp16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dusp16 here. Most of them are supplied by our site. Hope this information will be useful for your research of dusp16.

    MAPK14

    Park, H; Park, SY; et al. Discovery of Novel DUSP16 Phosphatase Inhibitors through Virtual Screening with Homology Modeled Protein Structure. JOURNAL OF BIOMOLECULAR SCREENING 19:1383-1390(2014).
    Feurstein, S; Rucker, FG; et al. Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype. BMC GENOMICS 15:-(2014).

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