dusp9

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dusp9

Official Full Name dual specificity phosphatase 9
Background The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus.
Synonyms DUSP9; dual specificity phosphatase 9; dual specificity protein phosphatase 9; map kinase phosphatase 4; MKP 4; MKP4; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase 4; MKP-4
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Dusp9-2692M Recombinant Mouse Dusp9 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human DUSP9-5092H Recombinant Human DUSP9 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human DUSP9-12220H Recombinant Human DUSP9, His-tagged E.coli His
    Human DUSP9-2948H Recombinant Human DUSP9 Protein, GST-tagged Wheat Germ GST
    Human DUSP9-6769HCL Recombinant Human DUSP9 293 Cell Lysate HEK293 N/A
    Rhesus Macaque DUSP9-1357R Recombinant Rhesus monkey DUSP9 Protein, His-tagged Mammalian Cell His

    dusp9 involved in several pathways and played different roles in them. We selected most pathways dusp9 participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with dusp9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ARMS-mediated activation CSF2; DUSP6; DLG4; PEA15; KLB; PHB; PSMD14; IL17RD; SPTA1; CSK
    Axon guidance CDK5; RGMA; HRAS; ST8SIA2; PLXNA3; ARPC1A; EFNA2A; CSNK2A2; NRP2; SPTBN1
    Cytokine Signaling in Immune system EIF4A2; NRG2A; EDA; SPTA1; EGR1; ARIH1L; NRG4; EIF4G2; UBE2L6; DUSP9
    DAP12 interactions PAQR3A; NRG3; NRG4; PEA15; SPNA2; RASGRP1; CLEC5A; GRAP2B; AHCYL1; PAQR3B
    DAP12 signaling FGF20A; PEA15A; PRKAR1AA; SPRED3; AGO1; RASGEF1A; CNKSR1; FGF10B; AGO3; SPRED1
    Developmental Biology DCX; CRMP1; STX1B; SCN3A; EFNB3; CDK19; GDF1; SPTA1; EGR2; CNKSR1
    Downstream signal transduction KBTBD7; CRKL; RASGRP4; FGF20A; FGF8B; DAB2IPB; SPTA1; PTPRA; PAQR3B; SPRED3
    Downstream signaling of activated FGFR1 AGO2; KBTBD7; PAQR3B; PEA15; RASGEF1A; PTPRA; PEA15A; PAQR3A; SPRED1; DUSP2

    dusp9 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity, phosphoprotein phosphatase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by dusp9 itself. We selected most functions dusp9 had, and list some proteins which have the same functions with dusp9. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase tyrosine/serine/threonine phosphatase activity DUSP21; SACM1LB; DUSP2; PXYLP1; DUSP14; DUSP7; DUSP16; DUSP18; SACM1LA; PTPRQ
    phosphoprotein phosphatase activity SSH1; CTDSPL2A; PPP3CCA; PTPN11A; PPM1BA; DUSP16; PPP3CC; PPP1R3B; PTPRUB; PTPN11B
    protein binding ERCC8; ZNF131; PTPRO; RFC4; CCDC108; SLC9A1; UBASH3B; CDH1; E2F7; MIER1
    protein tyrosine phosphatase activity TPTE; EYA3; PTPN6; CDC14AB; PTPN20; DUSP23B; DUSP21; DUSP16; DUSP14; CDC25A
    protein tyrosine/serine/threonine phosphatase activity CDC14AA; EYA3; SGPP2; DUSP23A; CTDSPL2A; DUSP12; PTPMT1; DUSP23; CTDSPL2B; DUSP9

    dusp9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dusp9 here. Most of them are supplied by our site. Hope this information will be useful for your research of dusp9.

    Mapk14; MAPK14; MAPK3; MAPK1; CDK4; GSK3B; Mapk1; Mapk3; STK4; MAPK11

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