ECT2

  • Official Full Name

    epithelial cell transforming sequence 2 oncogene
  • Overview

    The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis.
  • Synonyms

    ECT2;epithelial cell transforming sequence 2 oncogene;protein ECT2;ARHGEF31;ECT 2;ECT2 protein;Epithelial Cell Transforming Sequence 2;Epithelial cell transforming sequence 2 oncogene protein;FLJ10461;MGC138291;OTTHUMP00000210539;OTTHUMP00000210684;OTTHUMP00000210685;OTTHUMP00000210686;epithelial cell-transforming sequence 2 oncogene

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • His
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
ECT2-2823H Recombinant Human ECT2 protein, His-tagged E.coli Human His
ECT2-1170Z Recombinant Zebrafish ECT2 Mammalian Cells Zebrafish His
ECT2-3040H Recombinant Human ECT2 Protein, GST-tagged Wheat Germ Human GST 46-145 a.a.
ECT2-4977M Recombinant Mouse ECT2 Protein Mammalian Cells Mouse His
ECT2-6728HCL Recombinant Human ECT2 293 Cell Lysate HEK293 Human Non
Ect2-1661M Recombinant Mouse Ect2 protein, His & GST-tagged E.coli Mouse GST&His Leu672~Leu905
ECT2-2632M Recombinant Mouse ECT2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
ECT2-2632M-B Recombinant Mouse ECT2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
ECT2-691H Recombinant Human ECT2 Protein, His-tagged E.coli Human His Leu166~Arg348

    Involved Pathway

    ECT2 involved in several pathways and played different roles in them. We selected most pathways ECT2 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE,G alpha (12/13) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ECT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    GPCR downstream signaling CRHR2,TRIO,CNR2,GRP,RHOL,ARHGEF1A,RGS18,OPN1SW1,SSTR4,OPN4A
    Regulation of RhoA activity ARHGEF18,OBSCN,NET1,ARHGEF10L,FARP1,ARHGAP9,ARHGEF15,ARHGEF10,DEF6,MYO9B
    PLK1 signaling events BORA,PLK1S1,TPT1,ERCC6L,TPX2,TCTN2,NDC80,SPC24
    Gastric cancer network 1 ESM1,TOP2A,C21orf33,RNF216,GATS,ACTL6A,TPX2,MYBL2,S100P,LIN9
    NRAGE signals death through JNK ARHGEF18,FGD4A,AATF,ABR,ARHGEF16,MCF2L,DCLRE1B,ARHGEF17,ARHGEF3,ARHGAP4A
    Cell death signalling via NRAGE, NRIF and NADE ITGB3BP,ARHGEF3,ARHGEF9,ARHGAP4A,CASP2,ARHGEF16,PLEKHG2,ARHGEF1A,BCL2L11,ARHGAP4
    G alpha (12/13) signalling events ARHGEF18,TIAM2,AKAP13,ADRA1B,KALRNB,TRIO,ARHGEF16,FGD4A,ADRA1D,OBSCN
    Rho GTPase cycle ARAP2,RHOT1A,ARHGEF16,FGD4A,ARHGAP17,ARHGAP29,TAGAPB,RHOT1,ARHGEF1A,ARHGAP1

    Protein Function

    ECT2 has several biochemical functions, for example, GTPase activator activity,Rho GTPase binding,Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ECT2 itself. We selected most functions ECT2 had, and list some proteins which have the same functions with ECT2. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activator activity RGS13,RGS14,ARAP1,RGS3,SIPA1L2,TBC1D3,RGS11,ELMOD1,RABGAP1,ARHGAP4
    signal transducer activity TAS2R104,BAI2,OPN4A,BST2,TAAR14E,OPN1LW1,PTK2BB,GPR173,OLFR11,PPFIA1
    protein binding RALB,ASCL1,CD160,THRAA,WDR77,CSPP1,CTCFL,TSPAN15,ARMC1,LANCL2
    Rho GTPase binding FMNL2,DIAP3,ARHGEF16,ROCK2A,LRRK2,DAPK3,ROCK2B,ARHGEF2,DIAPH1,ROCK2
    Rho guanyl-nucleotide exchange factor activity ARHGEF10,ARHGEF7A,FGD5,ARHGEF1,FGD6,BCR,RASGRF2B,C9orf100,TRIOA,VAV3
    protein homodimerization activity NKX2-5,PPP2R4,ABAT,COMMD1,PLD6,NOG,SLC9A7,MZF1,MTERFD3,QDPR

    Interacting Protein

    ECT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ECT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ECT2.

    RACGAP1;MYC;NCK1;PIK3R1;GRB2;Ect2;LAMTOR5;GPSM2;SAMD1;RBM45;SKA3

    Resources

    References

    • Suzuki, K; Sako, K; et al. Identification of non-Ser/Thr-Pro consensus motifs for Cdk1 and their roles in mitotic regulation of C2H2 zinc finger proteins and Ect2. SCIENTIFIC REPORTS 5:-(2015).
    • Harandi, OF; Ambros, VR; et al. Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E287-E296(2015).

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