EDAR

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EDAR

Official Full Name ectodysplasin A receptor
Background EDAR is a 49 kDa novel receptor of the TNFR family with one phosphorylation site at serine 324 residue and one death domain near the C-terminus (358-431 aa). Mutations in EDAR have been found in several families with autosomal hypohidrotic ectodermal dysp
Synonyms EDAR; ectodysplasin A receptor; DL, ectodysplasin 1, anhidrotic receptor , ED3; tumor necrosis factor receptor superfamily member EDAR; ED1R; ED5; EDA1R; EDA3; EDA-A1 receptor; downless homolog; ectodysplasin-A receptor; downless, mouse, homolog of
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Human cells
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • Flag
    • StrepII
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EDAR-0412H Recombinant Human EDAR protein, His-tagged E.coli His
    Human EDAR-12275H Recombinant Human EDAR, GST-tagged E.coli GST
    Human EDAR-1607H Recombinant Human Ectodysplasin A Receptor Mammalian cells N/A
    Human EDAR-2119H Recombinant Human Ectodysplasin A Receptor, Fc Chimera E.coli Fc
    Human EDAR-2247HCL Recombinant Human EDAR cell lysate Human Cell N/A
    Human EDAR-231H Recombinant Human EDAR, Fc-tagged CHO Fc
    Human EDAR-3047H Recombinant Human EDAR Protein, His/Flag/StrepII-tagged Human cells His/Flag/StrepII
    Human EDAR-3049H Recombinant Human EDAR Protein, GST-tagged Wheat Germ GST
    Human EDAR-3135H Recombinant Human EDAR, Fc tagged Human Cell Fc
    Human EDAR-3215H Recombinant Human EDAR, His tagged Human Cell His
    Human EDAR-601H Recombinant Human EDAR, Fc-tagged, Biotinylated Human Cell Fc
    Human EDAR-606H Recombinant Human ectodysplasin A receptor, His-tagged E.coli His
    Human EDAR-782H Recombinant Human EDAR Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human EDAR-921H Recombinant Human EDAR Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse Edar-1721M Recombinant Mouse Ectodysplasin-A Receptor Mammalian cells N/A
    Mouse Edar-2723M Recombinant Mouse Edar Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse EDAR-4981M Recombinant Mouse EDAR Protein Mammalian Cell His
    Rat EDAR-1537RCL Recombinant Rat EDAR cell lysate Human Cell N/A
    Rat Edar-7468R Recombinant Rat Edar, Fc tagged Human Cell Fc
    Cynomolgus Monkey EDAR-1021CCL Recombinant Cynomolgus EDAR cell lysate Human Cell N/A
    Cynomolgus Monkey EDAR-77C Recombinant Cynomolgus EDAR, His tagged Human Cell His
    Cynomolgus Monkey EDAR-8833C Recombinant Cynomolgus EDAR, Fc tagged Human Cell Fc
    Chicken EDAR-1980C Recombinant Chicken EDAR Mammalian Cell His
    Zebrafish EDAR-6522Z Recombinant Zebrafish EDAR Mammalian Cell His

    EDAR involved in several pathways and played different roles in them. We selected most pathways EDAR participated on our site, such as Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDAR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine Signaling in Immune system JAK3; CRKL; IL17RD; FRS3; TNFSF13B; GBP1; GBP6; NRG2A; IRF4; CSHL1
    Cytokine-cytokine receptor interaction CRFB2; IFNAR1; TNF; ACVR1L; TNFSF9; CCL11; PDGFAB; IL8L1; IL3RA; TNFSF15
    Immune System PVRL2L; PJA1; SPSB4; TIRAP; GZMM; CMTM2A; ABI2; CTS7; CLEC6A; BAIAP2
    Integrated Breast Cancer Pathway USP38; APOBEC3G; JAKMIP1; LGALS13; GDI1; PLK3; C21orf7; NOXA1; ZMIZ1; DAG1
    TNFR2 non-canonical NF-kB pathway EDAR; EDA; EDARADD
    TNFs bind their physiological receptors EDARADD; EDA; EDAR

    EDAR has several biochemical functions, for example, protein binding, receptor activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EDAR itself. We selected most functions EDAR had, and list some proteins which have the same functions with EDAR. You can find most of the proteins on our site.

    Function Related Protein
    protein binding FEN1; SULT1B1; ITGB7; LRRC47; STX5; SNRPC; COA6; TRMT112; TREML2; MEF2D
    receptor activity NLGN4Y; CADM4; HTR3A; Pla2r1; UBXN6; NRXN1; VPREB1; ATRN; JMJD6; NPC1
    transmembrane signaling receptor activity PTH1RB; TLR6; EBP; GHRHR2; CLDN3; CD3G; NFAM1; LILRA1; OR12D3; CD97

    EDAR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDAR here. Most of them are supplied by our site. Hope this information will be useful for your research of EDAR.

    Traf1; Traf2; TRAF3; EDARADD; EDA; MAP3K14

    Kowalczyk-Quintas, C; Schuepbach-Mallepell, S; et al. Pharmacological Stimulation of Edar Signaling in the Adult Enhances Sebaceous Gland Size and Function. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:359-368(2015).
    Hill, G; Headon, D; et al. Pharmacological Activation of the EDA/EDAR Signaling Pathway Restores Salivary Gland Function following Radiation-Induced Damage. PLOS ONE 9:-(2014).

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