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Official Full Name ephrin-B3
Background EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function.The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
Synonyms EFNB3; ephrin-B3; EPLG8; LERK 8; Ephrin B3; eph-related receptor tyrosine kinase ligand 8; EPH-related receptor transmembrane ligand ELK-L3; EFL6; LERK8
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • Yeast
    • Tag :
    • Fc
    • Fc Chimera
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EFNB3-153H Recombinant Human Ephrin-B3 E.coli N/A
    Human EFNB3-1612H Recombinant Human EFNB3 Mammalian cells N/A
    Human EFNB3-3106H Recombinant Human EFNB3 Protein, His-tagged E.coli His
    Human EFNB3-6965H Recombinant Human Ephrin-B3, His-tagged E.coli His
    Human EFNB3-713H Recombinant Human EFNB3, Fc Chimera Mammalian cells Fc Chimera
    Mouse EFNB3-2337M Recombinant Mouse EFNB3 Protein (28-227 aa), His-tagged Yeast His
    Mouse EFNB3-5035M Recombinant Mouse EFNB3 Protein Mammalian Cell His
    Mouse Efnb3-957M Recombinant Mouse Efnb3 Protein, Fc Chimera Mammalian cells Fc
    Mouse Efnb3-984M Recombinant Mouse Efnb3 Protein, Fc-tagged HEK293 Fc
    Mouse Efnb3-985M Recombinant Mouse Efnb3 Protein, His-tagged HEK293 His
    Rat EFNB3-1264RCL Recombinant Rat EFNB3 cell lysate Human Cell N/A
    Rat EFNB3-471R Recombinant Rat EFNB3 Protein (28-227 aa), His-tagged E.coli His
    Rat Efnb3-8716R Recombinant Rat Efnb3, Fc tagged Human Cell Fc
    Rat Efnb3-8717R Recombinant Rat Efnb3, His tagged Human Cell His

    efnb3 involved in several pathways and played different roles in them. We selected most pathways efnb3 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with efnb3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance COL9A3; PHB; MYL9; Ntng2; DPYSL5B; RGMB; EPHA1; DCC; NETO2; DPYSL3
    Developmental Biology MYL12A; PEBP1; PCSK6; CNKSR1; RGMB; SDCBP; CRMP1; BOC; COL4A5; EPHB4B
    EPH-Ephrin signaling EPHB4A; EFNA2; EFNB2A; DNM1; EFNA5; ACTR2; AP2A2; EFNA1A; EFNA1B; CLTC
    EPH-ephrin mediated repulsion of cells AP2B1; EFNA1; EPHB4B; EFNA2A; EPHA10; EFNA4; EFNB2; EFNB3B; EPHA2; AP2S1
    EPHB forward signaling ITSN1; EFNA5; EFNB3; GRB7; EFNB1; EFNB2
    EPHB-mediated forward signaling ACTR3; EFNB3B; EFNB2A; ARPC5; ACTR2; KALRN; ARPC4; KALRNB; ITSN1; ARPC1A
    Ephrin signaling EFNB3; EFNB2; EPHB4A; EFNB1; EFNB2A; SDCBP; EPHB4B; EFNB3B; EPHB3A; MYL12A

    efnb3 has several biochemical functions, for example, ephrin receptor binding, transmembrane-ephrin receptor activity, virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by efnb3 itself. We selected most functions efnb3 had, and list some proteins which have the same functions with efnb3. You can find most of the proteins on our site.

    Function Related Protein
    ephrin receptor binding EFNB2B; CRK; ANKS1B; EFNB3; EFNA5B; EPHA4; EFNA4; CDK5R1; EFNA1B; CBL
    transmembrane-ephrin receptor activity EPHA1; EFNA4; EPHB1; EPHA10; EFNB3; EPHA5; EFNA3; EPHB2; EPHA4
    virus receptor activity DPP4; CLDN1; LDLR; SLC1A5; CLEC4M; ICAM1; ITGB5; ITGB6; PVRL2; PVRL1

    efnb3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with efnb3 here. Most of them are supplied by our site. Hope this information will be useful for your research of efnb3.


    Baniwal, SK; Chimge, NO; et al. Prolactin-Induced Protein (PIP) Regulates Proliferation of Luminal A Type Breast Cancer Cells in an Estrogen-Independent Manner. PLOS ONE 8:-(2013).
    Steffen, DL; Xu, K; et al. Henipavirus Mediated Membrane Fusion, Virus Entry and Targeted Therapeutics. VIRUSES-BASEL 4:280-308(2012).

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