EGR2
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Official Full Name
early growth response 2 -
Overview
The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] -
Synonyms
EGR2;early growth response 2;AT591;CMT1D;CMT4E;KROX20;E3 SUMO-protein ligase EGR2;zinc finger protein Krox-20;early growth response protein 2;KROX-20, Drosophila, homolog (early growth response-2)
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- T7
- Avi
- Fc
Involved Pathway
EGR2 involved in several pathways and played different roles in them. We selected most pathways EGR2 participated on our site, such as Adipogenesis,BDNF signaling pathway,Calcineurin-regulated NFAT-dependent transcription in lymphocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | JUNB,EGR3,DGKA,CTLA4,EGR1,POU2F1,CSF2,IKZF1,EGR4,IRF4 |
| Developmental Biology | ARPC1B,NRP1A,SCN9A,CNTN6,PHB,EFNA1,EZRA,CAP1,SEMA3AA,COL9A1B |
| Hepatitis B | CYCS,BCL2,MAPK1,IKBKE,TICAM2,IFNA8,HBXIP,TGFB2,PTK2B,TGFBR1 |
| IL4-mediated signaling events | NIPAL1,CCL26,IgG3,DOK2,TFF3,MYBL1,MYB,PARP14,IRF4,RETNLB |
| Adipogenesis | NDN,GADD45A,CTNNB1,STIL,FOXC2,AGT,MEF2B,HMGA1-RS1,SPOCK1,NAMPT |
| HTLV-I infection | HLA-DRB4,PIK3R3,MAP2K4,HLA-DMB,WNT9A,IL15RA,VDAC2,DLG1,WNT7B,SLC25A6 |
| BDNF signaling pathway | LINGO1,DOK5,MAP3K2,SIRPA,EIF2S1,CFL1,CDKL5,EIF4EBP1,CDK5,FRS3 |
| Transcriptional regulation of white adipocyte differentiation | MED29,EBF1,NR2F2,MED18,MED19,MED21,CDK19,MED22,MED9 |
Protein Function
EGR2 has several biochemical functions, for example, HMG box domain binding,RNA polymerase II activating transcription factor binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EGR2 itself. We selected most functions EGR2 had, and list some proteins which have the same functions with EGR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | TRIM68,UBE3B,BTRC,MUL1A,CDC34A,UBE2NA,PJA2,TRIM37,PELI3,FPGS |
| transcription factor activity, sequence-specific DNA binding | ZNF584,YY1,ZNF92,ZFP583,TLX2,DMRTA1,ZHX2,SREBF1,NKX6-2,ZNF193 |
| protein binding | MPHOSPH8,DVL3,PHF15,RASGRP3,TRPC7,SYCE2,PLK2,SH3PXD2A,FIS1,THBS2 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | SMAD1,HOXD13,MAFB,CREB3L1,ONECUT3,TRP53,DLX3,TCF4,IRF1,ARID3B |
| metal ion binding | ZFP474,SKINT8,ZFPM2,PIKFYVE,ZFP292,ZNF786,HAGHL,NRXN2,ZFP184,NME2 |
| RNA polymerase II activating transcription factor binding | TBX20,ZFPM1,JUN,SIN3A,HIPK2,CREBBP,HEY2,MAD2L2,CREB1,EOMES |
| chromatin binding | PYGO2,IFT74,OST4,Ar,SMARCC1,CHD8,HIST2H3C1,YBX1,CRTC2,PHF13 |
| ubiquitin protein ligase binding | UCHL1,FZD8,MOAP1,MUL1,MAP1LC3C,RPA2,XRCC5,KCNQ3,UBE2G1A,USP2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | HELT,NFKB2,CTCF,SNAI3,IFI203,PBX1,NFATC2,MED1,RBPJ,ZNF257 |
Interacting Protein
EGR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGR2.
NDUFS2;BPGM;ACP5;HCFC1;RPL7L1;RBM15B;HN1L;RIMKLB;MED31;Nab2
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References
- Okamura, T; Sumitomo, S; et al. TGF-beta 3-expressing CD4(+)CD25(-)LAG3(+) regulatory T cells control humoral immune responses. NATURE COMMUNICATIONS 6:-(2015).
- Pletinckx, K; Vaeth, M; et al. Immature dendritic cells convert anergic nonregulatory T cells into Foxp3(-)IL-10(+) regulatory T cells by engaging CD28 and CTLA-4. EUROPEAN JOURNAL OF IMMUNOLOGY 45:480-491(2015).
