EGR2 Protein


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Official Full Name early growth response 2
Background The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Synonyms EGR2; early growth response 2; AT591; CMT1D; CMT4E; KROX20; E3 SUMO-protein ligase EGR2; zinc finger protein Krox-20; early growth response protein 2; KROX-20, Drosophila, homolog (early growth response-2);
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EGR2-12329H Recombinant Human EGR2, GST-tagged E.coli GST
    Human EGR2-28469TH Recombinant Human EGR2 Wheat Germ N/A
    Human EGR2-3123H Recombinant Human EGR2 Protein, GST-tagged Wheat Germ GST
    Human EGR2-6691HCL Recombinant Human EGR2 293 Cell Lysate HEK293 N/A
    Human EGR2-6976H Recombinant Human EGR2 protein, His & T7-tagged E.coli His/T7
    Human EGR2-777H Recombinant Human EGR2 Protein, His-tagged E.coli His
    Mouse Egr2-30M Recombinant Mouse Egr2 protein, His-tagged E.coli His
    Mouse EGR2-5053M Recombinant Mouse EGR2 Protein Mammalian Cell His
    Rat EGR2-2033R Recombinant Rat EGR2 Protein Mammalian Cell His
    Rhesus Macaque EGR2-1400R Recombinant Rhesus monkey EGR2 Protein, His-tagged Mammalian Cell His

    EGR2 involved in several pathways and played different roles in them. We selected most pathways EGR2 participated on our site, such as Adipogenesis, BDNF signaling pathway, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adipogenesis NR1H3; NDN; CISD1; NRIP1; NR2F1A; STIL; CNTFR; MEF2AA; AHR; BMP1
    BDNF signaling pathway EGR2; CDKL5; CDH2; DOK5; GNB2L1; SYN1; MAP3K2; EIF4EBP1; BCL2L11; YBX1
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes IKZF1; JUNB; EGR4; CDK4; IRF4; EGR1; CTLA4; CSF2; BATF3; DGKA
    Developmental Biology EFNA4; LGI1B; ARHGEF28; KALRNB; EPHA10; CACNG2; SEMA4D; DLG3; MED9; EFNA1B
    Hepatitis B NFATC4; PTK2B; IFNA12; AKT1; Ifna15; ELK1; PCNA; IFNA1; IFNB1; IL-8
    IL4-mediated signaling events NIPAL1; MYB; IRF4; DOK2; EGR2; IgG3; TFF3; RETNLB; MYBL1; CCL26
    Transcriptional regulation of white adipocyte differentiation MED19; MED18; MED21; CDK19; MED29; NR2F2; EBF1; MED22; EGR2; MED9

    EGR2 has several biochemical functions, for example, HMG box domain binding, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EGR2 itself. We selected most functions EGR2 had, and list some proteins which have the same functions with EGR2. You can find most of the proteins on our site.

    Function Related Protein
    HMG box domain binding DLX5; ALX4; PAX3; GATA3; JUN; HOXA3; SP1; HOXC4; MEOX1; UTF1
    RNA polymerase II activating transcription factor binding IFI27; EOMES; SIN3A; CREB1; EP300; BHLHE40; LDB1; ZFPM1; HNF4A; TBX3
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ATF4; AEBP2; CEBPA; ZNF718; MYOG; FLI1; FUBP3; POU3F2; RFX4; HSF1
    chromatin binding ADNP; HMG20A; SOD3; CEBPB; TCF7L2; PHF8; SMARCC1; MEIOB; ORC1L; NUPR1
    ligase activity HERC6; MIB2; TNFAIP3; UBE2F; UBE2D1A; HECW1; RNF13; TRIM27; LIPT2; DTX2
    metal ion binding COL1A1; ZFP513; ZNF263; PRICKLE1B; FGD; NR6A1A; ZZEF1; ZFP146; NEURL3; ZBTB43
    protein binding IGSF8; VEPH1; RNF32; IFT46; SPC24; ATP1B1; CDK8; RPL5; CTR9; TUFT1
    transcription factor activity, sequence-specific DNA binding SLAMF7; FOXG1; ZFP770; DLX3; TRERF1; HOXC6A; POU5F2; PHTF1; RORC; ZNF165
    transcription regulatory region DNA binding ZNF217; ARRB1; XRCC5; HIVEP2A; BASP1; ATF3; FOS; SNCA; MLL1; GABPB2
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding NRF1; NPAS4; CREB3; TP63; BATF; HOXD13; WT1; EBF3A; SMAD2; OTX2
    ubiquitin protein ligase binding CALR; LYN; PIAS1; TRAF5; ERLIN2; POU5F1; LTBR; PRR5L; VCL; ATP6V0C

    EGR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EGR2.


    Okamura, T; Sumitomo, S; et al. TGF-beta 3-expressing CD4(+)CD25(-)LAG3(+) regulatory T cells control humoral immune responses. NATURE COMMUNICATIONS 6:-(2015).
    Pletinckx, K; Vaeth, M; et al. Immature dendritic cells convert anergic nonregulatory T cells into Foxp3(-)IL-10(+) regulatory T cells by engaging CD28 and CTLA-4. EUROPEAN JOURNAL OF IMMUNOLOGY 45:480-491(2015).

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